INT5299

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Context Info
Confidence 0.34
First Reported 1986
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.51
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tacr3) plasma membrane (Tacr3) nucleus (Tacr3)
cytoplasm (Tacr3) signal transducer activity (Tacr3)
Anatomy Link Frequency
spinal cord 3
sensory neurons 1
muscle 1
caudate putamen 1
bladder 1
Tacr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 24 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
agonist 12 99.96 Very High Very High Very High
antagonist 11 99.96 Very High Very High Very High
Inflammation 4 99.00 Very High Very High Very High
Dorsal horn 8 98.96 Very High Very High Very High
dorsal root ganglion 2 98.80 Very High Very High Very High
tetrodotoxin 2 98.64 Very High Very High Very High
Spinal cord 20 98.38 Very High Very High Very High
opiate 7 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 15 99.92 Very High Very High Very High
INFLAMMATION 5 99.00 Very High Very High Very High
Ganglion Cysts 2 98.80 Very High Very High Very High
Dysmenorrhea 4 79.28 Quite High
Overactive Bladder 2 73.32 Quite High
Pain 2 45.52 Quite Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of the tachykinin NK3 receptor antagonist SB235375 and the opioid receptor antagonist naloxone on changes in bladder activity induced by [MePhe]-NKB were also investigated.
Regulation (effects) of NK3 receptor in bladder
1) Confidence 0.34 Published 2005 Journal J. Urol. Section Body Doc Link 16006975 Disease Relevance 0.07 Pain Relevance 0
Effects of a nonpeptide tachykinin NK3 receptor antagonist, SR 142801, were studied in the isolated spinal cord preparation of the neonatal rat.
Regulation (Effects) of NK3 receptor in spinal cord associated with antagonist and spinal cord
2) Confidence 0.28 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9920451 Disease Relevance 0 Pain Relevance 0.21
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord.
Regulation (Effects) of NK3 receptor in spinal cord associated with qutenza, antagonist and spinal cord
3) Confidence 0.28 Published 1998 Journal Neuropeptides Section Title Doc Link 9920451 Disease Relevance 0 Pain Relevance 0.39
Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat.
Regulation (regulation) of neurokinin 3 in uterine associated with qutenza
4) Confidence 0.26 Published 2002 Journal Biol. Reprod. Section Title Doc Link 12390879 Disease Relevance 0.12 Pain Relevance 0.29
In the current study, we furthered our investigations of the role of estrogen in the regulation of NK3-R-mediated myometrial contractility.
Regulation (regulation) of NK3-R-mediated
5) Confidence 0.26 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 12390879 Disease Relevance 0.08 Pain Relevance 0.15
We have been using rat spinal cord-dorsal root ganglion primary cocultures (SC-DG) as a model system for exploring K receptor regulation.
Regulation (regulation) of K receptor in spinal cord associated with ganglion cysts, dorsal root ganglion and spinal cord
6) Confidence 0.26 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828988 Disease Relevance 0.17 Pain Relevance 0.40
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons.
Regulation (regulation) of neurokinin-3 receptor in sensory neurons associated with inflammation and substance p
7) Confidence 0.13 Published 1999 Journal Neuroscience Section Title Doc Link 10430499 Disease Relevance 0.40 Pain Relevance 0.43
This study investigated changes in NK-1 and NK-3 receptor mRNA expression during nociception.
Spec (investigated) Regulation (changes) of NK-3 receptor mRNA associated with nociception
8) Confidence 0.12 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.34 Pain Relevance 0.61
Neurokinin-3 receptor messenger RNA expression levels varied closely with, and thus may be regulated by, the levels of neurokinin B messenger RNA in the same regions.
Regulation (regulated) of Neurokinin-3 receptor
9) Confidence 0.11 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.32 Pain Relevance 0.75
Changes in neurokinin B-like immunoreactivity (NKB-IR) and neurokinin B mRNA were investigated after daily injection of haloperidol for 10 days on adjacent sections by means of immunocytochemistry and in situ hybridization in the caudate putamen of the rat.
Regulation (Changes) of neurokinin B-like immunoreactivity in caudate putamen
10) Confidence 0.08 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1300504 Disease Relevance 0 Pain Relevance 0.13
Application of NMDA or AMPA had no effect on NK3 receptor.
Neg (no) Regulation (effect) of NK3 receptor
11) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.31
Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum.
Regulation (response) of NK-3 receptor in muscle associated with agonist
12) Confidence 0.04 Published 1994 Journal J Auton Pharmacol Section Title Doc Link 7512089 Disease Relevance 0 Pain Relevance 0.25

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