INT5300

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Context Info
Confidence 0.60
First Reported 1981
Last Reported 2010
Negated 25
Speculated 3
Reported most in Abstract
Documents 54
Total Number 57
Disease Relevance 11.33
Pain Relevance 29.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
brain 6
hypothalamus 4
plasma 3
neural lobe 3
pituitary 3
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 89 100.00 Very High Very High Very High
Enkephalin 54 100.00 Very High Very High Very High
Morphine 39 100.00 Very High Very High Very High
Calcitonin gene-related peptide 34 100.00 Very High Very High Very High
Somatostatin 32 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
opiate 19 100.00 Very High Very High Very High
Clonidine 15 100.00 Very High Very High Very High
Pain threshold 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 17 100.00 Very High Very High Very High
Sprains And Strains 17 99.64 Very High Very High Very High
Ganglion Cysts 14 99.48 Very High Very High Very High
Convulsion 10 98.72 Very High Very High Very High
Stress 89 98.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 166 97.36 Very High Very High Very High
Neurogenic Inflammation 3 96.16 Very High Very High Very High
Diabetes Mellitus 197 95.76 Very High Very High Very High
Overactive Bladder 2 94.92 High High
Headache 10 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that fluctuations in ovarian hormones may influence oestrous Ir-beta-EP levels both under normal conditions and after exposure to stress.
Spec (may) Regulation (influence) of Ir-beta-EP associated with stress
1) Confidence 0.60 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6321625 Disease Relevance 0.37 Pain Relevance 0.07
Thoracic spinal block caused a remarkable increase in the amount of Fos-IR in Lamina V, but had no significant effect on the Fos-IR in Laminae I and II.
Neg (no) Regulation (effect) of Fos-IR in Lamina
2) Confidence 0.58 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843805 Disease Relevance 0 Pain Relevance 0
These SNPs, in exons 13 and 17, do not alter the normal INSR polypeptide sequence.
Neg (not) Regulation (alter) of INSR
3) Confidence 0.50 Published 2006 Journal Eur J Med Genet Section Abstract Doc Link 16473310 Disease Relevance 0.87 Pain Relevance 0.79
In intact rats, plasma ir-beta EP was elevated fourfold, and ir-beta EP levels in AP and N-IL significantly reduced after 30 min swimming; in contrast, HT ir-beta EP in these animals was not affected.
Neg (not) Regulation (affected) of ir-beta EP in plasma
4) Confidence 0.48 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6300719 Disease Relevance 0.34 Pain Relevance 0.41
Furthermore, treatment with the D(2)/D(3) receptor agonist quinpirol (1 mg/kg) and D(2)/D(3) receptor antagonist raclopride (1 mg/kg) had no effect in MOR IR, suggesting that D(4) R is the only D2-like receptor producing an MOR downregulation in the islands.
Neg (no) Regulation (effect) of IR associated with antagonist, mu opioid receptor and agonist
5) Confidence 0.45 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17366605 Disease Relevance 0.07 Pain Relevance 1.12
The aim of this study was twofold: (1) to document changes in levels of immunoreactive beta-endorphin (Ir-beta-EP) in the hypothalamus, anterior pituitary gland, neurointermediate lobe and plasma during the oestrous cycle of the rat and (2) to investigate stress-induced changes in plasma Ir-beta-EP at different stages of the oestrous cycle.
Regulation (changes) of Ir-beta-EP in plasma associated with stress
6) Confidence 0.44 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6321625 Disease Relevance 0.22 Pain Relevance 0.07
The objective of the present study was to search for putative long-term changes in the contents of immunoreactive (IR) Met-enkephalin (IR-Met), Leu-enkephalin (IR-Leu) and opioid octapeptide Met--Arg(6)--Gly(7)--Leu(8) (IR-Oct) in specific brain areas, after the execution of different amounts of sexual activity.
Regulation (changes) of IR-Leu in brain associated with enkephalin and opioid
7) Confidence 0.43 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 11844571 Disease Relevance 0.07 Pain Relevance 0.72
The objective of the present study was to search for putative long-term changes in the contents of immunoreactive (IR) Met-enkephalin (IR-Met), Leu-enkephalin (IR-Leu) and opioid octapeptide Met--Arg(6)--Gly(7)--Leu(8) (IR-Oct) in specific brain areas, after the execution of different amounts of sexual activity.
Regulation (changes) of IR-Met in brain associated with enkephalin and opioid
8) Confidence 0.43 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 11844571 Disease Relevance 0.07 Pain Relevance 0.71
Changes of plasma, hypothalamic and pituitary immunoreactive beta-endorphin (IR-beta-end), methionine-enkephalin (IR-Met-enk) and ACTH (IR-ACTH) were studied under various conditions of feeding and watering in rats.
Regulation (Changes) of IR-ACTH in plasma associated with enkephalin
9) Confidence 0.42 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3018810 Disease Relevance 0 Pain Relevance 0.17
The possibility of an interaction between neurotransmitter systems and estrogen in affecting levels of immunoreactive beta-endorphin (IR-BE) in the anterior pituitary (AP), the neurointermediate lobe of the pituitary (NIL) and the hypothalamus was investigated in ovariectomized (OVX) female rats.
Regulation (affecting) of IR-BE in lobe associated with neurotransmitter
10) Confidence 0.39 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.17
Neonatal capsaicin treatment and enteric nerve section did not affect the concentrations of IR-7B2 in the rat intestine.
Neg (not) Regulation (affect) of IR-7B2 in intestine associated with qutenza
11) Confidence 0.36 Published 1988 Journal Dig. Dis. Sci. Section Abstract Doc Link 3286156 Disease Relevance 0 Pain Relevance 0.10
In light of previous data showing that morphine down-regulates beta E biosynthesis in the hypothalamus, the present results suggest that the regulation of beta E-ir peptides in the spinal cord is distinct from that found in other CNS areas.
Regulation (regulation) of beta E-ir in spinal cord associated with spinal cord and morphine
12) Confidence 0.34 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8492132 Disease Relevance 0 Pain Relevance 1.05
The effects of chronic treatment with methadone, a long-acting opiate agonist, and naltrexone, a long-acting opiate antagonist on brain immunoreactive beta-endorphin (IR-beta-EP) concentrations were studied in the rat.
Regulation (effects) of IR-beta-EP in brain associated with antagonist, agonist, opiate and methadone
13) Confidence 0.34 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6314167 Disease Relevance 0 Pain Relevance 0.81
The density of Sub.P-IR fibers in the gastric wall was not affected by GSX.
Neg (not) Regulation (affected) of Sub.P-IR
14) Confidence 0.33 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9201090 Disease Relevance 0 Pain Relevance 0.74
Chronic administration of cocaine did not affect the concentration of IR-BE in the hypothalamus.
Neg (not) Regulation (affect) of IR-BE in hypothalamus associated with cocaine
15) Confidence 0.32 Published 1988 Journal Life Sci. Section Abstract Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.38
To investigate the basis of these alterations, the present study examined the effects of prenatal exposure to morphine on tyrosine hydroxylase immunoreactivity (TH-IR) in the brains of adult male and female progeny.
Spec (examined) Regulation (effects) of TH-IR in brains associated with morphine
16) Confidence 0.25 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10718519 Disease Relevance 0.07 Pain Relevance 0.57
The administration of capsaicin during the neonatal period or in adult life had no effect on the transport of IR-SS, but greatly decreased the transport of substance P.
Neg (no) Regulation (effect) of IR-SS associated with qutenza, somatostatin and substance p
17) Confidence 0.25 Published 1984 Journal Endocrinology Section Abstract Doc Link 6200314 Disease Relevance 0.17 Pain Relevance 0.66
The present study examined the effect of chronic exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin-induced locomotor sensitisation and Fos-immunoreactivity (Fos-IR).
Spec (examined) Regulation (effect) of Fos-IR
18) Confidence 0.23 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16137723 Disease Relevance 0 Pain Relevance 0.11
USA), in the areas of rat spinal cord was localized by immunohistochemical PAP methods, and the changes of alpha o-immunoreactivity (alpha o-IR) in the substantia gelatinosa (SG) were observed after unilateral transection of dorsal roots and electroacupuncture.
Regulation (changes) of alpha o-IR in spinal cord associated with substantia gelatinosa, electroacupuncture and spinal cord
19) Confidence 0.22 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648697 Disease Relevance 0.06 Pain Relevance 0.49
In the ipsilateral L5 DRG, the proportion of ASIC3-ir neurons was not significantly affected by treatment.
Neg (not) Regulation (affected) of ir in neurons associated with dorsal root ganglion
20) Confidence 0.22 Published 2008 Journal Brain Res. Section Abstract Doc Link 18534561 Disease Relevance 0.78 Pain Relevance 1.43

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