INT53003

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.36
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
lamina 2
nucleus 2
hippocampus 2
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 10 99.98 Very High Very High Very High
qutenza 1 99.68 Very High Very High Very High
Hippocampus 67 99.60 Very High Very High Very High
cytokine 1 99.12 Very High Very High Very High
long-term potentiation 10 99.02 Very High Very High Very High
Inflammation 17 95.72 Very High Very High Very High
intrathecal 7 94.48 High High
agonist 4 93.56 High High
Dorsal horn 33 92.84 High High
cerebral cortex 6 89.60 High High
Disease Link Frequency Relevance Heat
Depression 10 99.98 Very High Very High Very High
Stress 5 99.98 Very High Very High Very High
Apoptosis 10 99.56 Very High Very High Very High
Hepatocellular Cancer 1 96.28 Very High Very High Very High
INFLAMMATION 16 95.72 Very High Very High Very High
Cancer 7 94.84 High High
Aids-related Complex 36 90.76 High High
Aging 1 86.52 High High
Genomic Instability 1 82.12 Quite High
Nervous System Injury 1 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the fact that long-term potentiation induction in the hippocampus during waking (WK) leads to zif-268 gene upregulation in the cortex during subsequent REM sleep (Ribeiro et al., 2002), that such upregulation requires concomitant hippocampal activity (Ribeiro et al., 2002), and that it progresses over time in an anterograde manner across specific cortical areas (Ribeiro et al., 2002), we proposed that REM sleep is a privileged window for the propagation of memory traces from the hippocampus to the cerebral cortex (Pavlides and Ribeiro, 2003; Ribeiro and Nicolelis, 2004; Ribeiro et al., 2002).
Positive_regulation (leads) of Positive_regulation (upregulation) of zif-268 in hippocampus associated with hippocampus, long-term potentiation and cerebral cortex
1) Confidence 0.64 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.09 Pain Relevance 0.18
Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.
Positive_regulation (caused) of Positive_regulation (induction) of NGFI-A in nucleus associated with stress and qutenza
2) Confidence 0.49 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.42 Pain Relevance 0.14
Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA.
Neg (not) Positive_regulation (-induced) of Positive_regulation (elevations) of NGFI-A associated with depression
3) Confidence 0.49 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.61 Pain Relevance 0.68
Our data also suggests that the induction of c-Fos and Egr-1 by propofol is mediated by the p38-MAPK/ERK signaling cascade.
Positive_regulation (mediated) of Positive_regulation (induction) of Egr-1
4) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Positive_regulation (-) of Positive_regulation (regulated) of Zif268 in lamina associated with inflammation
5) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.39
Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells.
Positive_regulation (mediated) of Positive_regulation (induction) of Egr-1 associated with hepatocellular cancer, apoptosis and cytokine
6) Confidence 0.05 Published 2008 Journal Oncol. Rep. Section Title Doc Link 18202802 Disease Relevance 0.94 Pain Relevance 0.05

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