INT53007

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Context Info
Confidence 0.27
First Reported 1994
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.28
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
paw 4
spinal cord 4
finger 2
funiculus 2
Fosl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
Gabapentin 8 100.00 Very High Very High Very High
orphanin 7 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
intrathecal 4 100.00 Very High Very High Very High
Dopamine 6 99.74 Very High Very High Very High
Enkephalin 3 99.74 Very High Very High Very High
Intracerebroventricular 5 99.46 Very High Very High Very High
spinal dorsal horn 2 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 11 100.00 Very High Very High Very High
Stress 5 100.00 Very High Very High Very High
Pain 3 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike its inhibition of formalin-evoked nociceptive behaviors, the effect of gabapentin on the expression of Fos-like immunoreactivity in the spinal cord was highly dependent on the concentration of formalin.
Regulation (effect) of Gene_expression (expression) of Fos-like in spinal cord associated with nociception, gabapentin and spinal cord
1) Confidence 0.27 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10640314 Disease Relevance 0.42 Pain Relevance 1.04
In this case, adrenalectomy increased cocaine-induced changes in extracellular dopamine but did not modify the expression of Fos-like proteins.
Neg (not) Regulation (modify) of Gene_expression (expression) of Fos-like associated with dopamine and cocaine
2) Confidence 0.25 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207816 Disease Relevance 0 Pain Relevance 0.72
The authors examined the effect of 17 nmol of nociceptin on the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by paw formalin injection and compared the effect of 17 nmol of nociceptin with that of equiantinociceptive dose (3 nmol) of morphine.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Fos-like immunoreactivity in paw associated with spinal dorsal horn, orphanin and morphine
3) Confidence 0.21 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10773422 Disease Relevance 0 Pain Relevance 0.83
Here we demonstrate the effect of stress on the expression of fra-1, fra-2 and recently characterized IEGs encoding zinc finger containing proteins.
Regulation (effect) of Gene_expression (expression) of fra-1 in finger associated with stress
4) Confidence 0.16 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.36 Pain Relevance 0.13
Intracerebroventricular injection of 26RFa had no effect on the expression of Fos-like immunoreactivity induced by paw formalin injection in the superficial layers of the spinal dorsal horn.
Neg (no) Regulation (effect) of Gene_expression (expression) of Fos-like in paw associated with spinal dorsal horn and intracerebroventricular
5) Confidence 0.14 Published 2009 Journal Peptides Section Abstract Doc Link 19520126 Disease Relevance 0.16 Pain Relevance 0.86
Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat.
Regulation (effects) of Gene_expression (expression) of Fos-like in spinal cord associated with nociception, agonist, mu opioid receptor, enkephalin and spinal cord
6) Confidence 0.08 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9435201 Disease Relevance 0.10 Pain Relevance 0.96
The effects of intrathecal (i.t.) phentolamine (Ph), cyproheptadine (Cyp), and naloxone (Nal), administered separately or coadministered by two of them, on the expression of Fos-like-immunoreactive (FLI) neurons were observed on both sides of the lumbar dorsal horn of rats, in which equal volumes of formalin were injected into two hindpaws and the ipsilateral dorsolateral funiculus (DLF) was transected at the thoracic level antecedently.
Regulation (effects) of Gene_expression (expression) of Fos-like-immunoreactive in funiculus associated with dorsal horn, narcan and intrathecal
7) Confidence 0.04 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350573 Disease Relevance 0.24 Pain Relevance 0.51

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