INT53008

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Context Info
Confidence 0.74
First Reported 1994
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 4.89
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
neurons 5
cortex 2
temporal cortex 2
Neocortex 1
adrenal gland 1
Nr4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 120 100.00 Very High Very High Very High
Catechol-O-methyltransferase 5 100.00 Very High Very High Very High
qutenza 7 99.54 Very High Very High Very High
cerebral cortex 24 99.24 Very High Very High Very High
midbrain 2 98.70 Very High Very High Very High
medulla 9 96.08 Very High Very High Very High
Somatosensory cortex 17 95.32 Very High Very High Very High
Thalamus 17 91.60 High High
interneuron 3 90.80 High High
Catecholamine 3 79.84 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 304 100.00 Very High Very High Very High
Stress 26 99.84 Very High Very High Very High
Schizophrenia 29 98.04 Very High Very High Very High
Targeted Disruption 11 91.92 High High
Sprains And Strains 3 91.48 High High
Body Weight 44 90.08 High High
Urological Neuroanatomy 20 88.28 High High
Syndrome 32 84.96 Quite High
Disease 39 83.64 Quite High
Stroke 7 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.
Gene_expression (expression) of Nurr1 in adrenal gland associated with stress and qutenza
1) Confidence 0.74 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.41 Pain Relevance 0.28
NGFI-A, NGFI-B and Nurr1 expression persisted for 6 h.
Gene_expression (expression) of Nurr1
2) Confidence 0.74 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.48 Pain Relevance 0.36
The PC1–PC2 plot of different cortical areas shown in Fig. 7B indicates the features of these areas characterized by RORbeta, ER81 and Nurr1 gene expressions.
Gene_expression (expressions) of Nurr1 gene
3) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Furthermore, the expression levels of Nurr1 in the temporal cortex ventral area (TeV) and ectorhinal cortex (Ect) (about 90% of the mediodorsal distance at the bregma distance of ?
Gene_expression (expression) of Nurr1 in temporal cortex
4) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.05
It is quite intriguing that Nurr1 mRNA is expressed by a subtype of neurons distinct from those expressing RORbeta or ER81 mRNAs despite the extensive intermingling (Fig. 3).
Gene_expression (expressed) of Nurr1 mRNA in neurons
5) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Regarding Nurr1 gene expression, the positive cells represent only a minor population of the layer 6 neurons, and the area distribution pattern was completely different from that of the Nissl-GLI.
Gene_expression (expression) of Nurr1 gene in neurons
6) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
The expressions of RORbeta, ER81 and/or Nurr1 genes may be affected, directly or indirectly, by the thalamocortical inputs and contribute to the low PC1 scores in the primary sensory areas.
Gene_expression (expressions) of Nurr1
7) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.05
The expression of fra-1, NGFI-C, egr-3 and Nurr1 did not show any change.
Gene_expression (expression) of Nurr1
8) Confidence 0.52 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.41 Pain Relevance 0.14
Analysis of Area-Specific Expression Patterns of RORbeta, ER81 and Nurr1 mRNAs in Rat Neocortex by Double In Situ Hybridization and Cortical Box Method

Background

Gene_expression (mRNAs) of Nurr1 in Neocortex
9) Confidence 0.45 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
On the other hand, RORbeta and Nurr1 mRNAs were not coexpressed in the same neurons even in the areas with extensive intermingling (Fig. 3D–3F).
Neg (not) Gene_expression (coexpressed) of Nurr1 in neurons
10) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Similarly, ER81 and Nurr1 mRNAs were not expressed within the same neurons (Fig. 3G–3I).
Neg (not) Gene_expression (expressed) of Nurr1 in neurons
11) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Every seventh section was preserved for ISH using RORbeta, ER81 and Nurr1 gene probes and Nissl staining.
Gene_expression (probes) of Nurr1 gene
12) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0.06 Pain Relevance 0
Analysis for area-specific distribution patterns of RORbeta, ER81 and Nurr1 mRNAs by cortical box method
Gene_expression (mRNAs) of Nurr1
13) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0.08 Pain Relevance 0
Kim et al. reported that a midbrain dopaminergic phenotype with TH-positive neurons was promoted by expressing nuclear receptor related-1 (Nurr1) with adding the trophic factors FGF8 and SHH [38].
Gene_expression (expressing) of Nurr1 in midbrain associated with midbrain
14) Confidence 0.42 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2838763 Disease Relevance 0.84 Pain Relevance 0.10
The distribution pattern shown in Fig. 6A suggests that the RORbeta mRNA expression level is high in the sensory areas, whereas the ER81 and Nurr1 mRNA expression levels are generally high in the areas with low RORbeta mRNA expression level.
Gene_expression (expression) of Nurr1 mRNA
15) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Furthermore, the expression levels of Nurr1 in the temporal cortex ventral area (TeV) and ectorhinal cortex (Ect) (about 90% of the mediodorsal distance at the bregma distance of ?
Gene_expression (levels) of Nurr1 in temporal cortex
16) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.05
We studied the area-specific expression patterns of three layer-specific genes, RORbeta, ER81 and Nurr1, using double ISH and the cortical box method [31].
Gene_expression (expression) of Nurr1
17) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
To make maps for layers 2/3, 4, 5 and 6, we first determined the borders of these layers based on Nissl staining, as well as the ISH patterns of the three layer-specific genes, RORbeta, ER81 and Nurr1.
Gene_expression (patterns) of Nurr1
18) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
In the present study, we used the rat cortex as a model system to analyze the area-specific expression patterns of three “layer-specific” mRNAs, RORbeta [14], ER81 [10], [22], [23] and Nurr1 [13], [19], [23], which are expressed mainly in layers 4, 5 and 6 of the rodent neocortex, respectively.
Gene_expression (expressed) of Nurr1 in cortex
19) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
In the present study, we used the rat cortex as a model system to analyze the area-specific expression patterns of three “layer-specific” mRNAs, RORbeta [14], ER81 [10], [22], [23] and Nurr1 [13], [19], [23], which are expressed mainly in layers 4, 5 and 6 of the rodent neocortex, respectively.
Spec (analyze) Gene_expression (expression) of Nurr1 in cortex
20) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0

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