INT53015

Context Info Confidence 0.78 First Reported 1994 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 50 Total Number 51 Disease Relevance 9.05 Pain Relevance 26.23

nucleus (TP53INP2)

Anatomy Link Frequency ovary 4 fibroblasts 2 skin 2 keratinocytes 2 embryonic kidney 2 TP53INP2 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 621 100.00 Delta opioid receptors 175 100.00 Opioid 153 100.00 Morphine 27 100.00 Spinal cord 75 99.96 agonist 242 99.84 Endogenous opioid 4 99.84 Dextromethorphan 15 99.82 Peripheral nerve injury 10 99.52 Kappa opioid receptor 21 99.50

Disease Link Frequency Relevance Heat Nervous System Injury 14 99.08 Ganglion Cysts 16 98.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 60 97.72 Disease 8 97.72 Tics 4 97.52 Hyperalgesia 4 96.80 Nociception 32 96.68 Neuropathic Pain 18 96.20 Injury 5 96.04 Neuroblastoma 10 94.08

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Protein

Mutation

Event

Anatomy

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Speculation

Pain term

Disease term

Accordingly, in rodent spinal cord, DOR mRNA was expressed by a large number of neurons distributed throughout the ventral and dorsal horns, whereas in the primate, DOR expression was significantly lower, as evidenced by a moderate number of labeled cells throughout the gray matter in monkey and by only few labeled cells in human, mainly in Clarke's column and lamina IX.

Gene_expression (expressed) of DOR mRNA in ventral associated with delta opioid receptors and spinal cord

1) Confidence 0.78 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.06 Pain Relevance 0.74

Immunoprecipitation experiments demonstrated that beta-arrestin 1 physically interacts with delta opioid receptor (DOR) co-expressed in human embryonic kidney 293 cells in an agonist-enhanced manner and truncation of the carboxyl terminus of DOR partially impairs the interaction.

Gene_expression (co-expressed) of DOR in embryonic kidney associated with agonist and opioid receptor

2) Confidence 0.66 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259507 Disease Relevance 0 Pain Relevance 0.67

Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.

Gene_expression (expression) of DOR in fibroblasts

3) Confidence 0.64 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0

Real-time PCR indicated that the expression of MOR, DOR and KOR in hypertrophic scars was enhanced in comparison with normal skin.

Gene_expression (expression) of DOR in skin

4) Confidence 0.64 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.07 Pain Relevance 0

CONCLUSIONS: Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.

Gene_expression (expression) of DOR

5) Confidence 0.64 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0

These results demonstrate major differences in the expression and distribution of DOR in the spinal cord and DRG between mammalian species.

Gene_expression (expression) of DOR in DRG associated with delta opioid receptors and spinal cord

6) Confidence 0.60 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.28 Pain Relevance 0.77

A considerable number of research papers describing the synthesis and testing of the delta opioid receptor (DOR) ligands, SNC-80 and TAN-67, and analogues of these two compounds, have been published in recent years.

Gene_expression (synthesis) of DOR associated with opioid receptor

7) Confidence 0.54 Published 2001 Journal Bioorg. Med. Chem. Section Abstract Doc Link 11557349 Disease Relevance 0 Pain Relevance 0.31

When a MOR fused to a non-functional Galpha subunit was co-expressed with the DOR-Galpha protein fusion, delta opioid signalling was not affected whereas mu opioid signalling was restored.

Gene_expression (co-expressed) of DOR associated with opioid

8) Confidence 0.54 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182056 Disease Relevance 0.34 Pain Relevance 0.74

Accordingly, in rodent spinal cord, DOR mRNA was expressed by a large number of neurons distributed throughout the ventral and dorsal horns, whereas in the primate, DOR expression was significantly lower, as evidenced by a moderate number of labeled cells throughout the gray matter in monkey and by only few labeled cells in human, mainly in Clarke's column and lamina IX.

Gene_expression (expression) of DOR in ventral associated with delta opioid receptors and spinal cord

9) Confidence 0.53 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.13 Pain Relevance 0.76

In contrast, in monkey and human DRG, DOR mRNA was primarily detected over small and medium-sized ganglion cells.

Gene_expression (detected) of DOR mRNA in ganglion cells associated with ganglion cysts and delta opioid receptors

10) Confidence 0.53 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.27 Pain Relevance 0.84

Major species differences in DOR expression were also observed in primary afferent cells bodies.

Gene_expression (expression) of DOR associated with delta opioid receptors

11) Confidence 0.53 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.22 Pain Relevance 0.79

Delta-opioid receptor (DOR) transcripts and binding sites are expressed by lymphocytes and lymphoid cell lines from several species.

Gene_expression (expressed) of DOR in lymphocytes associated with opioid receptor

12) Confidence 0.52 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9744564 Disease Relevance 0.13 Pain Relevance 0.36

A human embryonic kidney 293 cell line was established that expressed an epitope-tagged delta-opioid receptor (DOR).

Gene_expression (expressed) of DOR in embryonic kidney associated with opioid receptor

13) Confidence 0.46 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.05

RESULTS: Immunofluorescence staining revealed that OR types mu (MOR), delta (DOR) and kappa (KOR) were coexpressed and located mainly in the keratinocytes and fibroblast-like cells.

Gene_expression (coexpressed) of DOR in fibroblast

14) Confidence 0.43 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.08 Pain Relevance 0

These results suggest that decreases in the expression of DOR are a common feature of peripheral nerve injury.

Gene_expression (expression) of DOR in peripheral nerve associated with nervous system injury, opioid receptor and peripheral nerve injury

15) Confidence 0.41 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135930 Disease Relevance 0.95 Pain Relevance 1.15

Reduced expression of delta-opioid receptors (DOR) following peripheral nerve injury has been reported but most of these reports are limited to subjective observation.

Gene_expression (expression) of DOR in peripheral nerve associated with nervous system injury, opioid receptor, delta opioid receptors and peripheral nerve injury

16) Confidence 0.36 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135930 Disease Relevance 0.89 Pain Relevance 1.46

Using fluorescence microscopy, we visualized hDOR internalization promoted by different agonists in SK-N-BE cells expressing FLAG-tagged hDOR.

Gene_expression (expressing) of hDOR associated with agonist

17) Confidence 0.27 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12672796 Disease Relevance 0.15 Pain Relevance 0.61

Accordingly, in rodent spinal cord, DOR mRNA was expressed by a large number of neurons distributed throughout the ventral and dorsal horns, whereas in the primate, DOR expression was significantly lower, as evidenced by a moderate number of labeled cells throughout the gray matter in monkey and by only few labeled cells in human, mainly in Clarke's column and lamina IX.

Gene_expression (expressed) of DOR mRNA in dorsal horns associated with delta opioid receptors and spinal cord

18) Confidence 0.26 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966560 Disease Relevance 0.06 Pain Relevance 0.74

² = 0.43], which was accounted for by the increasing difference in RTs between laterally and medially rotated stimuli over the stimulus sets, resulting in significant simple DOR effects in Set-2 [F(1,11) = 5.964, P < 0.05, ?

Gene_expression (effects) of DOR

19) Confidence 0.23 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0

As we only obtained a significant DOR effect in the sets including palm view stimuli, one might argue that only the palm view stimuli accounted for the obtained DOR effect in Set-2 and Set-3.

Gene_expression (effect) of DOR

20) Confidence 0.23 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0.03

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