INT53021

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 27.75
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
middle ear 1
plasma cells 1
cartilage 1
cleavage 1
articular cartilage 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 300 99.82 Very High Very High Very High
rheumatoid arthritis 163 98.96 Very High Very High Very High
Arthritis 48 97.92 Very High Very High Very High
alcohol 4 97.66 Very High Very High Very High
spinal inflammation 13 97.60 Very High Very High Very High
Earache 13 95.92 Very High Very High Very High
cytokine 332 94.80 High High
Inflammation 595 85.52 High High
algogenic 2 75.00 Quite High
imagery 68 71.28 Quite High
Disease Link Frequency Relevance Heat
Otitis Media 1538 100.00 Very High Very High Very High
Recurrence 62 100.00 Very High Very High Very High
Arthritis 47 99.98 Very High Very High Very High
Rhinitis 21 99.98 Very High Very High Very High
Osteoarthritis 226 99.82 Very High Very High Very High
Bacteremia 26 99.80 Very High Very High Very High
Bacterial Meningitis 67 99.76 Very High Very High Very High
Knee Osteoarthritis 86 99.70 Very High Very High Very High
Otitis Media With Effusion 551 99.60 Very High Very High Very High
Lower Respiratory Tract Infection 17 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Streptococcus pneumoniae is a known cause of AOM and bacteremia in children.
Positive_regulation (cause) of AOM associated with otitis media, bacterial meningitis and bacteremia
1) Confidence 0.55 Published 2010 Journal International Journal of Pediatrics Section Body Doc Link PMC2933858 Disease Relevance 2.73 Pain Relevance 0.09
For EMSCOT we adapted the method for use with mother-child pairs and found evidence for effects of maternal genotype given child's genotype and imprinting for both COL2A1 rs1635544 (P?
Positive_regulation (imprinting) of COL2A1
2) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.31 Pain Relevance 0
However, it was 25% lower than those reported in the Greater Boston studies (9) where 45% of children were affected, but rates were higher than in a Swedish study (12) where only 21% had experienced episodes of AOM by one year of age.
Positive_regulation (experienced) of AOM associated with otitis media
3) Confidence 0.43 Published 2007 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2754010 Disease Relevance 0.78 Pain Relevance 0
ELISA assays of collagenase-cleaved type II collagen
Positive_regulation (cleaved) of type II collagen
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.10 Pain Relevance 0.05
OME may be a precursor initiating AOM but also a complication thereof.
Positive_regulation (initiating) of AOM associated with otitis media and otitis media with effusion
5) Confidence 0.40 Published 2007 Journal Eur J Pediatr Section Abstract Doc Link PMC1876255 Disease Relevance 1.83 Pain Relevance 0.04
For all samples from RA knees, an inhibition assay was performed using the citrullinated type II collagen as antigen

Anti-citrullinated type II collagen antibodies in synovial extracts

Positive_regulation (citrullinated) of type II collagen in knees associated with rheumatoid arthritis
6) Confidence 0.40 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780673 Disease Relevance 1.36 Pain Relevance 0.56
Inhibition studies were performed by preincubating sera with buffered NRS containing citrullinated type II collagen at a concentration of 20 ?
Positive_regulation (citrullinated) of type II collagen
7) Confidence 0.40 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780673 Disease Relevance 0.09 Pain Relevance 0.04
Rhinitis increased the likelihood of AOM (RR 2.3; P < 0.001) as did excessive crying in children older than 2 years of age (RR 3.0; P < 0.001).
Positive_regulation (increased) of AOM associated with rhinitis and otitis media
8) Confidence 0.40 Published 1994 Journal Pediatr. Infect. Dis. J. Section Abstract Doc Link 7808842 Disease Relevance 1.24 Pain Relevance 0.27
DATA COLLECTION AND ANALYSIS: Two authors independently extracted the data for: any AOM; episodes of AOM; any recurrent AOM; episodes of illness; any side effects; any antibiotic resistance, as well as outcomes at end of intervention (any AOM); and following cessation of intervention (any AOM).
Positive_regulation (extracted) of AOM
9) Confidence 0.40 Published 2006 Journal Cochrane Database Syst Rev Section Body Doc Link 17054203 Disease Relevance 0.07 Pain Relevance 0
All studies enrolled children at increased risk of AOM, and in seven studies the children were prone to otitis media.
Positive_regulation (increased) of AOM
10) Confidence 0.40 Published 2006 Journal Cochrane Database Syst Rev Section Body Doc Link 17054203 Disease Relevance 0.05 Pain Relevance 0
Pneumococcal conjugate vaccine, licensed in the United States in 2000, was shown in two pivotal trials to reduce the incidence of all causes of AOM by 6%, and pneumococcal AOM by 34%.
Positive_regulation (causes) of AOM associated with otitis media
11) Confidence 0.40 Published 2007 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2754010 Disease Relevance 1.27 Pain Relevance 0
Of all children, 40% had AOM during the first year of life.
Positive_regulation (had) of AOM associated with otitis media
12) Confidence 0.39 Published 1999 Journal Acta Otolaryngol. Section Abstract Doc Link 10219388 Disease Relevance 1.42 Pain Relevance 0.09
Treatment with an alcohol extract of Echinacea purpurea root and seeds at times of upper respiratory infection was associated with a modestly increased risk of AOM.
Positive_regulation (increased) of AOM in respiratory associated with otitis media, lower respiratory tract infection and alcohol
13) Confidence 0.38 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2573879 Disease Relevance 0.54 Pain Relevance 0.05
Treatment of AOM
Positive_regulation (Treatment) of AOM associated with otitis media
14) Confidence 0.35 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 0.89 Pain Relevance 0.04
Significant elevations of IgA1 antibodies against type II collagen (p < 0.01) and IgA2 antibodies against type I (p < 0.001), III (p < 0.001), and IV (p < 0.01) collagens were observed in AS patients compared with those of healthy controls.
Positive_regulation (elevations) of type II collagen associated with spinal inflammation
15) Confidence 0.34 Published 1997 Journal Scand. J. Rheumatol. Section Abstract Doc Link 9385351 Disease Relevance 0.37 Pain Relevance 0.44
Increasing recognition of H. influenzae overtaking S. pneumoniae as the most frequent cause of AOM has recently been observed [9].
Positive_regulation (cause) of AOM associated with otitis media
16) Confidence 0.33 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 0.55 Pain Relevance 0
While both bacteria and/or viruses can cause AOM, the most serious infections are believed to involve bacterial pathogens [6], particularly Streptococcus pneumoniae (S. pneumoniae) or non-typeable Haemophilus influenzae (NTHi), which together account for at least 60-70% of clinical AOM episodes [7].
Positive_regulation (cause) of AOM associated with hemophilus infection, bacterial meningitis, otitis media and infection
17) Confidence 0.33 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 1.65 Pain Relevance 0
Acute otitis media (AOM) is one of the most frequently encountered bacterial infections in children aged < 5 years; Streptococcus pneumoniae (S. pneumoniae) and non-typeable Haemophilus influenzae (NTHi) are historically identified as primary AOM causes.
Positive_regulation (causes) of AOM associated with hemophilus infection, bacterial meningitis, otitis media and bacterial infection
18) Confidence 0.33 Published 2011 Journal BMC Infect Dis Section Abstract Doc Link PMC3023699 Disease Relevance 1.16 Pain Relevance 0
Nevertheless, recent data on bacterial pathogens causing AOM in Latin America are limited.
Positive_regulation (causing) of AOM associated with otitis media
19) Confidence 0.33 Published 2011 Journal BMC Infect Dis Section Abstract Doc Link PMC3023699 Disease Relevance 1.19 Pain Relevance 0
Global data shows the most common pneumococcal serotypes causing AOM are 3, 6A, 6B, 9V, 14, 19A, 19F and 23F [38] indicating that potential coverage for pneumococcal serotypes included in the available formulations ranged from 60-86% [37,39].
Positive_regulation (causing) of AOM associated with otitis media
20) Confidence 0.33 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 0.66 Pain Relevance 0

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