INT53028

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.65
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYCS) transport (CYCS) mitochondrion (CYCS)
small molecule metabolic process (CYCS) nucleus (CYCS)
Anatomy Link Frequency
blood 1
CYCS (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 6 99.62 Very High Very High Very High
cINOD 5 90.24 High High
qutenza 5 82.84 Quite High
imagery 2 81.04 Quite High
withdrawal 1 72.52 Quite High
peptic ulcer disease 1 67.24 Quite High
lidocaine 1 66.32 Quite High
Inflammation 7 63.24 Quite High
fibrosis 5 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 99.98 Very High Very High Very High
Sprains And Strains 8 99.64 Very High Very High Very High
INFLAMMATION 9 84.08 Quite High
Targeted Disruption 1 81.44 Quite High
Death 1 81.04 Quite High
Colon Cancer 2 79.60 Quite High
Rupture 2 79.12 Quite High
Stress 5 75.00 Quite High
Gastritis 3 75.00 Quite High
Leukemia 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also shown that piroxicam can reduce cytochrome c within a time frame relevant to its lifetime in blood plasma.
Negative_regulation (reduce) of cytochrome c in blood
1) Confidence 0.57 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17306218 Disease Relevance 0.20 Pain Relevance 0.17
The method is based on the reduction of cytochrome C by superoxide anion.
Negative_regulation (reduction) of cytochrome C
2) Confidence 0.57 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2978317 Disease Relevance 0 Pain Relevance 0.10
However, only phenylbutazone caused inactivation of alpha 1-antiproteinase in the presence of cytochrome c and H2O2.
Negative_regulation (inactivation) of cytochrome c
3) Confidence 0.42 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 7811298 Disease Relevance 0.07 Pain Relevance 0.07
The induction of ROS and DNA fragmentation in the mucosal cells in association with these H. pylori strains were assessed by cytochrome c reduction (an index of superoxide anion production), hydroxyl radical production, and DNA fragmentation.
Negative_regulation (reduction) of cytochrome c associated with sprains and strains
4) Confidence 0.42 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064819 Disease Relevance 0.99 Pain Relevance 0.07
Both cell types underwent a reduction in the levels of anti-apoptotic Bcl-2 protein, cytochrome c loss from mitochondria and activation of caspase 9 together with caspase 3, independently of p53 status.
Negative_regulation (loss) of cytochrome c associated with apoptosis
5) Confidence 0.42 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.88 Pain Relevance 0.30
ROS generation occurs in an early stage of diclofenac-induced apoptosis preceding cytochrome c release, caspase activation, and DNA fragmentation.
Negative_regulation (preceding) of cytochrome c associated with apoptosis and diclofenac
6) Confidence 0.41 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.51 Pain Relevance 0.39

General Comments

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