INT5303

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 19
Total Number 25
Disease Relevance 5.25
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC3) extracellular region (TAC3)
Anatomy Link Frequency
sperm 5
nucleus 2
testis 2
sensory neurons 1
spinal cord 1
TAC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 173 100.00 Very High Very High Very High
Central nervous system 11 99.72 Very High Very High Very High
Dorsal horn 4 99.20 Very High Very High Very High
Dismenorea 2 99.00 Very High Very High Very High
Dynorphin 17 98.86 Very High Very High Very High
agonist 47 98.64 Very High Very High Very High
Spinal cord 2 98.44 Very High Very High Very High
Neuropeptide 8 98.06 Very High Very High Very High
Kappa opioid receptor 3 96.88 Very High Very High Very High
qutenza 18 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 15 99.76 Very High Very High Very High
Hypertrophy 5 99.74 Very High Very High Very High
Reprotox - General 1 8 99.32 Very High Very High Very High
Vasculitis 88 99.22 Very High Very High Very High
Dysmenorrhea 2 99.00 Very High Very High Very High
Endometriosis (extended) 12 98.94 Very High Very High Very High
Sperm Disorder 105 93.76 High High
Eclampsia 4 93.64 High High
Pain 1 90.32 High High
Hyperalgesia 1 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that human menopause is associated with marked increases in hypothalamic NKB and SP gene expression.
Gene_expression (expression) of NKB associated with endometriosis (extended)
1) Confidence 0.75 Published 1991 Journal Endocrinology Section Abstract Doc Link 1708331 Disease Relevance 0.17 Pain Relevance 0.17
Human menopause is characterised by ovarian failure, gonadotrophin hypersecretion and hypertrophy of neurones expressing neurokinin B (NKB), kisspeptin (KiSS)-1 and oestrogen receptor (ER) alpha gene transcripts within the hypothalamic infundibular (arcuate) nucleus.
Gene_expression (expressing) of NKB in nucleus associated with hypertrophy, endometriosis (extended) and reprotox - general 1
2) Confidence 0.74 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.35 Pain Relevance 0.13
Human menopause is characterised by ovarian failure, gonadotrophin hypersecretion and hypertrophy of neurones expressing neurokinin B (NKB), kisspeptin (KiSS)-1 and oestrogen receptor (ER) alpha gene transcripts within the hypothalamic infundibular (arcuate) nucleus.
Gene_expression (expressing) of neurokinin B in nucleus associated with hypertrophy, endometriosis (extended) and reprotox - general 1
3) Confidence 0.74 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.35 Pain Relevance 0.13
The genes that encode SP/NKA (TAC1), NKB (TAC3), hHK-1(TAC4), NEP (MME) and NEP2 (MMEL1) were detected in cDNAs from human sperm, testis and the pool of 20 human tissues used as positive control (Fig. 1).
Gene_expression (detected) of TAC3 in testis associated with substance p
4) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.05
The mRNAs of the genes that encode substance P/neurokinin A (TAC1), neurokinin B (TAC3), hemokinin-1 (TAC4), neprilysin (MME) and neprilysin-2 (MMEL1) were expressed in human sperm.
Gene_expression (expressed) of neurokinin B in sperm associated with substance p
5) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2936315 Disease Relevance 0.31 Pain Relevance 0.17
The genes that encode SP/NKA (TAC1), NKB (TAC3), hHK-1(TAC4), NEP (MME) and NEP2 (MMEL1) were detected in cDNAs from human sperm, testis and the pool of 20 human tissues used as positive control (Fig. 1).
Gene_expression (detected) of NKB in testis associated with substance p
6) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.05
The mRNAs of the genes that encode substance P/neurokinin A (TAC1), neurokinin B (TAC3), hemokinin-1 (TAC4), neprilysin (MME) and neprilysin-2 (MMEL1) were expressed in human sperm.
Gene_expression (expressed) of TAC3 in sperm associated with substance p
7) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2936315 Disease Relevance 0.31 Pain Relevance 0.17
We analyzed the expression of substance P, neurokinin A, neurokinin B, hemokinin-1, NEP and NEP2 in sperm cells by reverse-transcriptase polymerase chain reaction (RT-PCR), western blot and immunocytochemistry assays and evaluated the effects of the neprilysin and neprilysin-2 inhibitor phosphoramidon on sperm motility in the absence and presence of tachykinin receptor-selective antagonists.
Spec (analyzed) Gene_expression (expression) of neurokinin B in sperm cells associated with sperm disorder, antagonist and substance p
8) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2936315 Disease Relevance 0.24 Pain Relevance 0.13
NKB was not detectable in the sensory neurons of the guinea-pig.
Neg (not) Gene_expression (detectable) of NKB in sensory neurons
9) Confidence 0.46 Published 1986 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2430427 Disease Relevance 0.18 Pain Relevance 0.79
The genes that encode SP/NKA (TAC1), NKB (TAC3), hHK-1(TAC4), NEP (MME) and NEP2 (MMEL1) were detected in cDNAs from human sperm, testis and the pool of 20 human tissues used as positive control (Fig. 1).
Gene_expression (detected) of TAC3 in sperm associated with substance p
10) Confidence 0.20 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.05
The genes that encode SP/NKA (TAC1), NKB (TAC3), hHK-1(TAC4), NEP (MME) and NEP2 (MMEL1) were detected in cDNAs from human sperm, testis and the pool of 20 human tissues used as positive control (Fig. 1).
Gene_expression (detected) of NKB in sperm associated with substance p
11) Confidence 0.20 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.05
In the presence of the peptidase inhibitors (thiorphan, captopril and bestatin), the mammalian tachykinins SP, NKA and NKB produced concentration-dependent uterine contractions. 5.
Gene_expression (produced) of NKB in uterine associated with dismenorea and substance p
12) Confidence 0.16 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11071311 Disease Relevance 0.19 Pain Relevance 0.48
Expression of KiSS-1 and NKB was highly elevated in old perimenopausal compared with young or middle-aged premenopausal animals.
Gene_expression (Expression) of NKB
13) Confidence 0.07 Published 2010 Journal Endocrinology Section Abstract Doc Link 20519367 Disease Relevance 0.29 Pain Relevance 0.13
In contrast, long-term ( approximately 4 yr) OVX significantly increased KiSS-1 and NKB expression, and this was reversed by E(2) administration.
Gene_expression (expression) of NKB
14) Confidence 0.07 Published 2010 Journal Endocrinology Section Abstract Doc Link 20519367 Disease Relevance 0.28 Pain Relevance 0.09
NKB is also expressed at all main levels in the female genital tract [10,24-26,29-33] and its excessive secretion from the placenta may cause, in part, some of the symptoms of pre-eclampsia [24,25,31].
Gene_expression (expressed) of NKB in placenta associated with eclampsia
15) Confidence 0.06 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.14 Pain Relevance 0.09
The number of NKB mRNA-expressing cells (45%) and the grain density over single positive cells (37%) were significantly higher after the neuroleptic treatment.
Gene_expression (expressing) of NKB
16) Confidence 0.06 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1300504 Disease Relevance 0 Pain Relevance 0.24
The neuropeptides kisspeptin, neurokinin B, and dynorphin A (collectively abbreviated as KNDy) are, respectively, encoded by KiSS-1, NKB, and PDYN and are coexpressed by neurons of the hypothalamic arcuate nucleus (ARC).
Gene_expression (encoded) of NKB in ARC associated with dynorphin, aids-related complex and neuropeptide
17) Confidence 0.06 Published 2010 Journal Endocrinology Section Abstract Doc Link 20519367 Disease Relevance 0.23 Pain Relevance 0.14
These findings and our current observations showing that Tac2 mRNA is strongly repressed in uteri from young ovariectomized mice treated with E2 at all times of treatment indicate that at both central and peripheral levels, NKB over-expression is secondary to ovarian failure [19,38].
Gene_expression (expression) of NKB associated with reprotox - general 1
18) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.25 Pain Relevance 0.03
In the central nervous system, SP, NKA and NKB are expressed in subpopulations of hypothalamic and pituitary neurons where they influence, and are influenced by, gonadotropin and gonadal steroid levels [18-22] and modulate the synthesis and/or secretion of oxytocin [28].
Gene_expression (expressed) of NKB in gonadal associated with central nervous system and substance p
19) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.24
NKB, together with SP, kisspeptin and dinorphin, is present in a group of hypothalamic neurons that also express estrogen and progesterone receptors [19,21,42,43].
Gene_expression (present) of NKB in neurons associated with substance p
20) Confidence 0.04 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.08 Pain Relevance 0.10

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