INT53035

Context Info Confidence 0.43 First Reported 1994 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.47 Pain Relevance 0.33

plasma membrane (Grpr) signal transducer activity (Grpr)

Anatomy Link Frequency respiratory 1 Grpr (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 2 98.56 intrathecal 2 93.52 nMDA receptor 2 75.00 Hyperalgesia 1 71.76 Glutamate 1 60.00 anesthesia 1 25.00 qutenza 1 10.00 Dopamine 2 5.00

Disease Link Frequency Relevance Heat Nociception 4 97.04 Pressure And Volume Under Development 1 75.28 Hyperalgesia 1 71.76 Hypertension 1 30.64 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The respiratory effects evoked by systemic injection of bombesin were studied in spontaneously breathing rats that were (i) neurally intact and subsequently bilaterally vagotomized, (ii) intact, before and after pharmacological blockade of the bombesin BB(1) and BB(2) receptors.

Negative_regulation (blockade) of bombesin in respiratory

1) Confidence 0.43 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19032952 Disease Relevance 0.08 Pain Relevance 0.03

This effect was abolished by co-administration of [Leu13 psi(CH2NH)-Leu14]bombesin (10 nmol/rat), a bombesin receptor antagonist.

Negative_regulation (co-administration) of bombesin associated with antagonist

2) Confidence 0.37 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813568 Disease Relevance 0.40 Pain Relevance 0.30

Cyclooxygenase inhibition with indomethacin partially reversed bombesin and mild irritant-induced gastroprotection but did not diminish the protective actions of L-DOPA.

Negative_regulation (reversed) of bombesin

3) Confidence 0.03 Published 1998 Journal Surgery Section Body Doc Link 9823400 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.