INT53036

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Context Info
Confidence 0.33
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.74
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
brain 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 46 100.00 Very High Very High Very High
Chronic pancreatitis 3 98.56 Very High Very High Very High
noradrenaline 5 98.36 Very High Very High Very High
fibrosis 6 97.88 Very High Very High Very High
Inflammation 13 97.36 Very High Very High Very High
Clonidine 2 97.12 Very High Very High Very High
agonist 6 90.40 High High
Calcium channel 5 89.44 High High
tetrodotoxin 1 89.16 High High
Root ganglion neuron 1 86.60 High High
Disease Link Frequency Relevance Heat
Cough 4 98.84 Very High Very High Very High
Pancreatitis 3 98.56 Very High Very High Very High
Pressure And Volume Under Development 7 98.44 Very High Very High Very High
Fibrosis 5 97.88 Very High Very High Very High
INFLAMMATION 9 97.36 Very High Very High Very High
Increased Venous Pressure Under Development 20 96.88 Very High Very High Very High
Hypoxia 162 94.44 High High
Coronary Artery Disease 4 87.08 High High
Ganglion Cysts 1 86.28 High High
Hyperlipidemia 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ang II and the nonpeptide AT1 and AT2 antagonists did not significantly compete for specific [125I]AMIPI binding in either brain region at concentrations of 10 microM (< 20% competition with each compound), which is 10- to 100-fold higher than the concentration necessary to compete completely for their respective Ang II receptor subtypes.
AT2 Binding (compete) of in brain associated with antagonist
1) Confidence 0.33 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877590 Disease Relevance 0 Pain Relevance 0.30
The involvement of angiotensin II receptor and its receptor interaction in the pathogenesis of spontaneous chronic pancreatitis was assessed in this model.
angiotensin II receptor Binding (interaction) of associated with chronic pancreatitis
2) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.69 Pain Relevance 0.52
The sensitivity to PD123319 of this response speaks in favour of a selective action via the AT2 receptor in turn activating NO synthesis.
AT2 Binding (receptor) of
3) Confidence 0.27 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.21 Pain Relevance 0.16
In addition to Ang II and its ligand-binding receptors AT1 and AT2, recent studies have shown that a metabolite of Ang II, a pentapeptide containing the 3-8 fragment of Ang II, namely angiotensin IV (Ang IV), is a biologically active peptide of the RAS.
AT2 Binding (-) of
4) Confidence 0.27 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.41 Pain Relevance 0
Also, the FITC-labeled Ang IV binding was not affected by the addition of excessive amount of Sarile (Fig. 1C,F,I), which saturated the AT1 and AT2 binding sites.
AT2 Binding (binding) of
5) Confidence 0.21 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.42 Pain Relevance 0
In addition to Ang II and its ligand-binding receptors AT1 and AT2, recent studies have shown that a metabolite of Ang II, a pentapeptide containing the 3-8 fragment of Ang II, namely angiotensin IV (Ang IV), is a biologically active peptide of the RAS.
AT2 Binding (binding) of
6) Confidence 0.20 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.41 Pain Relevance 0
Like other angiotensin II receptor antagonists, olmesartan medoxomil does not appear to be associated with adverse events such as cough and angioedema, which are often observed with ACE inhibitors.


angiotensin II receptor Binding (associated) of associated with pressure and volume under development, antagonist and cough
7) Confidence 0.17 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994016 Disease Relevance 0.96 Pain Relevance 0.32
The modulatory effect of angiotensin II was also evaluated after addition of both DUP753 and PD123319, an angiotensin AT2 receptor antagonist, and counteraction of the reduction in the IC50 value of l-noradrenaline was observed.
angiotensin AT2 receptor Binding (counteraction) of associated with antagonist and noradrenaline
8) Confidence 0.08 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.38
The regulation process mediated through G-protein-coupled receptors AT1 and AT2 (mostly through AT1 receptor) can also be blocked by specific receptor antagonist 4.
AT2 Binding (blocked) of associated with antagonist
9) Confidence 0.05 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2869452 Disease Relevance 0.55 Pain Relevance 0.12
Based on its high selectivity for mammalian VGSC subtypes, JZTX-II might be an important ligand for discrimination of VGSC subtypes and for exploration of the distribution and modulation mechanisms of VGSCs.
JZTX-II Spec (might) Binding (ligand) of
10) Confidence 0.02 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18840410 Disease Relevance 0.09 Pain Relevance 0.20

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