INT53038

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 23.76
Pain Relevance 11.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
blood 2
DRG 2
carotid body 1
coronary artery 1
vasculature 1
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 80 100.00 Very High Very High Very High
bradykinin 57 100.00 Very High Very High Very High
B1 receptor 8 100.00 Very High Very High Very High
adenocard 287 99.72 Very High Very High Very High
depression 7 99.64 Very High Very High Very High
Endogenous opioid 1 99.62 Very High Very High Very High
Spinal cord 41 99.52 Very High Very High Very High
Hyperalgesia 21 99.28 Very High Very High Very High
ischemia 62 98.80 Very High Very High Very High
opioid receptor 4 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 38 100.00 Very High Very High Very High
Coronary Artery Disease 8 99.84 Very High Very High Very High
Depression 7 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 56 99.44 Very High Very High Very High
Stress 21 99.44 Very High Very High Very High
Neuropathic Pain 171 99.36 Very High Very High Very High
Hyperalgesia 23 99.28 Very High Very High Very High
Nociception 71 98.80 Very High Very High Very High
Transient Ischemic Attack 3 98.80 Very High Very High Very High
Hypoxia 127 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, intrarenal angiotensin IV infusion produced vasoconstriction of the renal vasculature, mediated by activation of AT1 receptors.
Positive_regulation (activation) of AT1 in vasculature associated with increased venous pressure under development
1) Confidence 0.67 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10445671 Disease Relevance 0.10 Pain Relevance 0
Here we tested in vivo whether synaptic depression by adenosine A1 receptor (A1R) activation contributes to BS patterns following GCI.
Spec (whether) Positive_regulation (activation) of A1R associated with adenocard, depression and ischemia
2) Confidence 0.62 Published 2009 Journal Neuroscience Section Abstract Doc Link 19344634 Disease Relevance 0.72 Pain Relevance 0.56
Furthermore, the endogenous A1R activation may be the primary underlying cause of post-ischemic BS patterns following brief ischemic episodes.
Positive_regulation (activation) of A1R
3) Confidence 0.62 Published 2009 Journal Neuroscience Section Abstract Doc Link 19344634 Disease Relevance 0.87 Pain Relevance 0.66
It is unlikely that activation of either AT1 or alpha1-adrenergic receptor alone is crucial to trigger preconditioning.
Positive_regulation (activation) of AT1
4) Confidence 0.61 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10710117 Disease Relevance 0 Pain Relevance 0.16
The effects of angiotensin II are mediated through its stimulation of AT1 and AT2 receptors.
Positive_regulation (stimulation) of AT1
5) Confidence 0.59 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.38 Pain Relevance 0.05
In rats administered a high-salt diet (8% NaCl), the continuous intracerebroventricular infusion of FMRFamide (50 and 200 nmol. kg(-1). d(-1)) for 5 days increased mean arterial pressure, heart rate, urinary excretion of vasopressin and norepinephrine, and mRNAs of renin, angiotensin I-converting enzyme, and angiotensin II type 1 receptor in hypothalamus and brain stem compared with vehicle.
Positive_regulation (increased) of angiotensin II type 1 receptor in brain stem associated with intracerebroventricular
6) Confidence 0.53 Published 2000 Journal Hypertension Section Abstract Doc Link 10642339 Disease Relevance 0.15 Pain Relevance 0.42
Therefore, it can be surmised that the activation of angiotensin II AT1 receptors may reduce the transduction of the alpha 2-adrenoceptors and thus the alpha 2-mediated vasodepressor responses.
Positive_regulation (activation) of AT1
7) Confidence 0.45 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.32
Recent evidence also suggests that an activation of AT1 receptors could be involved in the cellular effects of Ang IV on intracellular signaling events [17, 18].
Positive_regulation (activation) of AT1
8) Confidence 0.43 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.41 Pain Relevance 0
The augmentation of Ang II sensitivity is mediated by an upregulation of AT1 receptors in the glomus cells of the carotid body [19, 21].
Positive_regulation (upregulation) of AT1 in carotid body
9) Confidence 0.43 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.64 Pain Relevance 0
It is likely that synaptic depression by post-ischemic A1R activation functionally disrupts the connectivity within the cortical networks to an extent that promotes BS patterns.
Positive_regulation (activation) of A1R associated with depression
10) Confidence 0.41 Published 2009 Journal Neuroscience Section Abstract Doc Link 19344634 Disease Relevance 0.81 Pain Relevance 0.61
This effect is in contrast to stimulation of the AT1 receptor which causes vasoconstriction and sodium retention.
Positive_regulation (stimulation) of AT1 receptor associated with increased venous pressure under development
11) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.96 Pain Relevance 0.20
After activation of Ang II type 1 (AT1) receptors, the cytoplasmic subunits bind to the membrane subunits and activate the enzyme, resulting in the intracellular production of O2?
Positive_regulation (activation) of AT1
12) Confidence 0.30 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.70 Pain Relevance 0.03
Several neurovascular systems are activated in T1D, including the inducible bradykinin (BK) B1 receptor (BKB1-R) subtype.
Positive_regulation (activated) of BKB1-R associated with diabetes mellitus, b1 receptor and bradykinin
13) Confidence 0.26 Published 2005 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16141788 Disease Relevance 1.39 Pain Relevance 0.79
The relation of the ACE and AT1R gene polymorphisms to coronary heart disease and the severity of coronary artery stenosis has now been investigated in 133 patients with myocardial infarction (MI) or angina pectoris who underwent coronary angiography and in 258 control subjects.
Spec (investigated) Positive_regulation (relation) of AT1R gene in coronary artery associated with coronary stenosis, angina, coronary artery disease and myocardial infarction
14) Confidence 0.21 Published 1996 Journal Atherosclerosis Section Abstract Doc Link 8842348 Disease Relevance 0.83 Pain Relevance 0.09
These data show that activation of A1R as a secondary consequence of MOR-activation and putative adenosine release will potentiate opioid synaptic inhibition of nociceptive circuitry.
Positive_regulation (activation) of A1R associated with nociception, adenocard, opioid receptor and opioid
15) Confidence 0.21 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698929 Disease Relevance 0.17 Pain Relevance 0.89
In the present study we show for the first time that the proteins of the contractile receptors ETB, AT1 and 5-HT1B receptors are upregulated in the smooth muscle cells of the MCA leading to the ischemic region and in microvessels associated with the focal ischemia.
Positive_regulation (upregulated) of AT1 in smooth muscle cells associated with ischemia
16) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.37 Pain Relevance 0.12
In rats administered a high-salt diet (8% NaCl), the continuous intracerebroventricular infusion of FMRFamide (50 and 200 nmol. kg(-1). d(-1)) for 5 days increased mean arterial pressure, heart rate, urinary excretion of vasopressin and norepinephrine, and mRNAs of renin, angiotensin I-converting enzyme, and angiotensin II type 1 receptor in hypothalamus and brain stem compared with vehicle.
Positive_regulation (increased) of angiotensin II type 1 receptor in hypothalamus associated with intracerebroventricular
17) Confidence 0.18 Published 2000 Journal Hypertension Section Abstract Doc Link 10642339 Disease Relevance 0.15 Pain Relevance 0.42
These results suggest that ischemia/reperfusion generated reactive oxygen species are derived from NADPH oxidase activation via AT1 receptor in rat stomachs.
Positive_regulation (activation) of AT1 receptor in stomachs associated with ischemia
18) Confidence 0.16 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436217 Disease Relevance 0.54 Pain Relevance 0.27
Since hypoxia counts for the expression of AT1b, the speculation that the AT1a subtype is induced by oxidative stress is tempting, although a review of literature appears absent in this regard and further investigation is required to confirm this hypothesis.
Positive_regulation (induced) of AT1a associated with stress and hypoxia
19) Confidence 0.09 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.51 Pain Relevance 0.06
This study provides the first functional evidence that Ang II inhibits the transmission of thermal nociceptive information through an endogenous opioid mechanism and the activation of an AT1 receptor in the rat spinal cord.
Positive_regulation (activation) of AT1 receptor in spinal cord associated with nociception, endogenous opioid and spinal cord
20) Confidence 0.09 Published 1997 Journal Life Sci. Section Abstract Doc Link 9247320 Disease Relevance 0.26 Pain Relevance 0.59

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