INT53040

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 7.36
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
brain 6
blood 1
sympathetic 1
glomus 1
nucleus 1
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 103 100.00 Very High Very High Very High
qutenza 3 100.00 Very High Very High Very High
adenocard 162 99.72 Very High Very High Very High
agonist 220 99.46 Very High Very High Very High
Kinase C 15 97.84 Very High Very High Very High
Clonidine 2 97.44 Very High Very High Very High
Pyramidal cell 42 97.28 Very High Very High Very High
cerebral cortex 9 95.96 Very High Very High Very High
opiate 2 95.00 High High
noradrenaline 5 91.36 High High
Disease Link Frequency Relevance Heat
Hypertension 93 99.80 Very High Very High Very High
Stress 11 99.18 Very High Very High Very High
Myocardial Infarction 137 98.96 Very High Very High Very High
Diabetes Mellitus 296 98.92 Very High Very High Very High
Cv General 2 Under Development 1 98.04 Very High Very High Very High
Shock 4 97.86 Very High Very High Very High
Hypoxia 280 94.44 High High
Coronary Heart Disease 10 90.80 High High
Diabetes Complications 2 90.48 High High
Cardiovascular Disease 8 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest the existence of an antagonistic angiotensin AT1/alpha 2-adrenoceptor interaction in the nucleus tractus solitarii.
AT1 Binding (interaction) of in nucleus
1) Confidence 0.47 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.34
g Rat Agtr1a (AT1R), Rat Mapk3 (ERK1), and Rat Mapk1 (ERK2) or control shRNA was incubated with 10 ?
Agtr1a Binding (incubated) of
2) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.07 Pain Relevance 0.07
AT1 receptors in the nucleus tractus solitarii mediate the interaction between the baroreflex and the cardiac sympathetic afferent reflex in anesthetized rats.
AT1 Binding (interaction) of in sympathetic associated with qutenza
3) Confidence 0.36 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 17053096 Disease Relevance 0 Pain Relevance 0.27
RNH-6270 inhibited [125I]angiotensin II binding to bovine adrenal cortical membranes (angiotensin AT1 receptors) with an IC50 value of 7.7 nM, but not [125I]angiotensin II binding to bovine cerebellar membranes (angiotensin AT2 receptors), indicating the selectivity of the compound for angiotensin AT1 receptors.
AT1 Binding (binding) of
4) Confidence 0.35 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566137 Disease Relevance 0 Pain Relevance 0.09
We studied the involvement of both NO metabolism and oxidative stress in L-NAME-induced hypertension, and how AT1 receptor antagonism may interact.
AT1 Binding (interact) of associated with stress and hypertension
5) Confidence 0.32 Published 2004 Journal Recept. Channels Section Abstract Doc Link 15989079 Disease Relevance 0.59 Pain Relevance 0.11
Angiotensin II mediates its activity via the AT1 receptor, which is selectively blocked by ARBs.
AT1 receptor Binding (activity) of
6) Confidence 0.32 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.89 Pain Relevance 0.12
Hence, activation of AT4 receptors in the glomus cells may interact with the AT1 receptor and its signalling pathway, and so this may activate protein kinase C for the Ang IV-induced [Ca2+]i response.
AT1 receptor Binding (interact) of in glomus associated with kinase c
7) Confidence 0.30 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.32 Pain Relevance 0.08
In addition to Ang II and its ligand-binding receptors AT1 and AT2, recent studies have shown that a metabolite of Ang II, a pentapeptide containing the 3-8 fragment of Ang II, namely angiotensin IV (Ang IV), is a biologically active peptide of the RAS.
AT1 Binding (-) of
8) Confidence 0.30 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.41 Pain Relevance 0
Nevertheless, the functional significance of the AT4 receptor expression may not be fully reflected by the [Ca2+]i response induced by Ang IV and the details of the Ang IV action and possible interaction with the AT1 receptors and its signaling cascades await elucidation by further studies.
AT1 Binding (interaction) of
9) Confidence 0.30 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.39 Pain Relevance 0.04
Blockade of the renin-angiotensin system with selective AT1 receptor antagonists is recognized as an effective mean to lower blood pressure in hypertensive patients.
AT1 Binding (recognized) of in blood associated with antagonist and hypertension
10) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2293961 Disease Relevance 0.17 Pain Relevance 0.10
Ang II and the nonpeptide AT1 and AT2 antagonists did not significantly compete for specific [125I]AMIPI binding in either brain region at concentrations of 10 microM (< 20% competition with each compound), which is 10- to 100-fold higher than the concentration necessary to compete completely for their respective Ang II receptor subtypes.
AT1 Binding (compete) of in brain associated with antagonist
11) Confidence 0.27 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877590 Disease Relevance 0 Pain Relevance 0.30
Interactions of ACE-inhibitors or AT1- antagonists with anesthetic agents can lead to severe hypotension especially in hypovolemic patients.
AT1 Binding (Interactions) of associated with cv general 2 under development and antagonist
12) Confidence 0.24 Published 2003 Journal Anaesthesist Section Abstract Doc Link 12898047 Disease Relevance 1.45 Pain Relevance 0.33
Although we can not rule out the possibility that Ang IV may directly activate the AT1 receptor with a dosage of exogenous Ang IV in the micromolar range, our binding studies with Sarile did not support the interpretation of such a non-specific binding of Ang IV to the AT1 receptor.
AT1 receptor Binding (binding) of
13) Confidence 0.23 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.42 Pain Relevance 0.07
In addition to Ang II and its ligand-binding receptors AT1 and AT2, recent studies have shown that a metabolite of Ang II, a pentapeptide containing the 3-8 fragment of Ang II, namely angiotensin IV (Ang IV), is a biologically active peptide of the RAS.
AT1 Binding (binding) of
14) Confidence 0.22 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.41 Pain Relevance 0
These results suggest that the diabetic heart is refractory to protection by Jak2-activating ligands because of AT1 receptor-mediated upregulation of calcineurin activity.173
AT1 receptor Binding (ligands) of in heart associated with diabetes mellitus
15) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.97 Pain Relevance 0.05
This relatively long half-life means angiotensin II type 1 receptor binding can be achieved with once-daily administration (Wehling 2004), which compares favorably with the half-lives of some other angiotensin II receptor antagonists: irbesartan (11–15 h), losartan (2 h) and its active metabolite (4–5 h), and valsartan (6 h).
angiotensin II type 1 receptor Binding (binding) of associated with antagonist
16) Confidence 0.11 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994016 Disease Relevance 0.18 Pain Relevance 0.05
In contrast to previously tested non-peptide ligands, L-162,313 bound with reasonably high affinity to the Xenopus laevis AT1 receptor.
AT1 Binding (bound) of
17) Confidence 0.09 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7829475 Disease Relevance 0 Pain Relevance 0.31
Functional and molecular interaction with the AT1 receptor.
AT1 Binding (interaction) of
18) Confidence 0.09 Published 1995 Journal J. Biol. Chem. Section Title Doc Link 7829475 Disease Relevance 0 Pain Relevance 0.29
Candesartan is an ARB that is administered orally as candesartan cilexetil; it is rapidly and completely converted to candesartan, the active compound, during absorption from the upper gastrointestinal tract.26 It is characterized by a strong binding affinity to the angiotensin II type 1 receptor and its slow dissociation.
angiotensin II type 1 receptor Binding (affinity) of in upper
19) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2801628 Disease Relevance 0.83 Pain Relevance 0
The adenosine A1 receptor (A1R) is known to regulate Ca2+/K+ channels, adenylate cyclase, and phospholipase C by coupling to Gi/o proteins [1].
A1R Binding (coupling) of associated with adenocard
20) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.13

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