INT53062

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 11.59
Pain Relevance 9.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
striatum 4
medulla 3
neurons 3
sensory neurons 1
blood 1
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 378 100.00 Very High Very High Very High
Dopamine 134 100.00 Very High Very High Very High
Glutamate 44 100.00 Very High Very High Very High
Rostral ventrolateral medulla 29 99.56 Very High Very High Very High
Catecholamine 15 99.20 Very High Very High Very High
c fibre 60 99.08 Very High Very High Very High
monoamine 9 98.56 Very High Very High Very High
withdrawal 112 98.48 Very High Very High Very High
noradrenaline 4 98.48 Very High Very High Very High
tetrodotoxin 15 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 383 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 211 100.00 Very High Very High Very High
Dyskinesias 54 99.64 Very High Very High Very High
Pressure Volume 2 Under Development 3 99.36 Very High Very High Very High
Heart Rate Under Development 12 99.20 Very High Very High Very High
Parkinsonian Disorders 2 98.88 Very High Very High Very High
Injury 305 98.56 Very High Very High Very High
Peripheral Neuropathy 80 98.32 Very High Very High Very High
Parkinson's Disease 26 98.16 Very High Very High Very High
Apoptosis 12 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During microdialysis of the right rostral ventrolateral medulla, extracellular basal levels of L-DOPA and three types of catecholamine were consistently detectable by high-performance liquid chromatography with electrochemical detection.
Gene_expression (levels) of L-DOPA in medulla associated with rostral ventrolateral medulla and catecholamine
1) Confidence 0.77 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0 Pain Relevance 0.66
Decreases in the expression of aromatic L-amino acid decarboxylase (Ddc) suggest that pathways controlling monoaminergic neurotransmitter synthesis may be affected by pyrethroids.
Gene_expression (expression) of Ddc associated with neurotransmitter and monoamine
2) Confidence 0.72 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.15 Pain Relevance 0.33
Transmitter-like L-DOPA functions as a tonic to produce postsynaptic cardiopressor responses in the rostral ventrolateral medulla (RVLM) of rats.
Gene_expression (produce) of L-DOPA in medulla associated with rostral ventrolateral medulla
3) Confidence 0.67 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072438 Disease Relevance 0.30 Pain Relevance 0.34
Decreases in the expression of aromatic L-amino acid decarboxylase (Ddc) suggest that pathways controlling monoaminergic neurotransmitter synthesis may be affected by pyrethroids.
Gene_expression (expression) of L-amino acid decarboxylase associated with neurotransmitter and monoamine
4) Confidence 0.63 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.15 Pain Relevance 0.33
NO was produced from L-DOPA in a dose-dependent manner and was scavenged by carboxy-PTIO in vitro.
Gene_expression (produced) of L-DOPA
5) Confidence 0.58 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11549108 Disease Relevance 0.16 Pain Relevance 0.12
In contrast to Camk1g, the microarray dose-response cohort demonstrated a dose-related change in Ddc expression for deltamethrin only, even though a clear dose-dependent decrease in Ddc mRNA expression was observed in both the deltamethrin and permethrin qRT-PCR cohorts.
Gene_expression (expression) of Ddc
6) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
Tetrodotoxin (1 microM) perfused into the right rostral ventrolateral medulla gradually decreased basal levels of L-DOPA by 25%; it decreased basal levels of noradrenaline and adrenaline by 25-30% and dopamine levels by 40%.
Gene_expression (levels) of L-DOPA in medulla associated with tetrodotoxin, dopamine, rostral ventrolateral medulla and noradrenaline
7) Confidence 0.52 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0.25 Pain Relevance 0.70
L-DOPA (10-300 ng) and L-glutamate (3-100 ng) microinjected into left NTS produced dose-dependent hypotension and bradycardia.
Gene_expression (produced) of L-DOPA associated with heart rate under development, glutamate and pressure volume 2 under development
8) Confidence 0.51 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072420 Disease Relevance 0.68 Pain Relevance 0.27
Phenylephrine i.v. infused produced L-DOPA release and reflex bradycardia, temporally associated with a rise and subsequent recovery of blood pressure.
Gene_expression (produced) of L-DOPA in blood associated with heart rate under development
9) Confidence 0.50 Published 1994 Journal Neuroscience Section Abstract Doc Link 7816196 Disease Relevance 0.25 Pain Relevance 0.35
In situ hybridization histochemistry showed that KW-6002 treatment alone caused an approximately 20% reduction in the striatal levels of preproenkephalin mRNA, whereas neither the coadministration of KW-6002 and L-DOPA nor L-DOPA alone significantly altered the expression of this transcript in the dopamine-denervated striatum.
Gene_expression (expression) of L-DOPA in striatum associated with dopamine
10) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12614340 Disease Relevance 0.43 Pain Relevance 0.27
Additionally, L-DOPA-induced elevations in striatal pre-proenkephalin-A (PPE-A) (but not PPE-B, phospho[Thr(34)]DARPP-32, D1, and D2 receptor mRNA or D3 receptor levels) were reduced in S33084 treated animals.
Gene_expression (levels) of L-DOPA
11) Confidence 0.49 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19118628 Disease Relevance 0.88 Pain Relevance 0.16
Thus, chronic ethanol ingestion but not ddC administration produces a decrease in average C-fiber mechanical threshold (43.5%; p < 0.05); in ddC-treated rats there was actually a small, not statistically significant, increase in mechanical threshold (Figure 2).


Gene_expression (produces) of ddC associated with c fibre
12) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1819368 Disease Relevance 0.50 Pain Relevance 1.18
METHODS: Conscious, fasted rats were given either capsaicin (125 mg/kg subcutaneously) to ablate sensory neurons or indomethacin (5 mg/kg intraperitoneally) to inhibit prostaglandin synthesis, 2 weeks and 30 minutes, respectively, before administration of bombesin (100 micrograms/kg subcutaneously), the dopamine precursor L-DOPA (25 mg/kg intraperitoneally), or the mild irritant 25% ethanol (1 mL orogastric).
Gene_expression (administration) of L-DOPA in sensory neurons
13) Confidence 0.41 Published 1998 Journal Surgery Section Body Doc Link 9823400 Disease Relevance 0 Pain Relevance 0
Cox-2 bioactivity had no effect on nerve growth factor-induced differentiation, epidermal growth factor-induced proliferation, or aromatic L-amino acid decarboxylase expression.
Gene_expression (expression) of L-amino acid decarboxylase in nerve associated with nerve growth factor
14) Confidence 0.35 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10766843 Disease Relevance 0.65 Pain Relevance 0.41
Neural stem cells that have been transplanted into 6-OHDA-lesioned rats have been shown to differentiate into neuronal cell types that express markers of dopaminergic neurons such as tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase (AADC) [16].
Gene_expression (express) of aromatic amino acid decarboxylase in Neural
15) Confidence 0.34 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2838763 Disease Relevance 0.78 Pain Relevance 0.38
L-DOPA microinjected (10-300 ng) dose-dependently produces postsynaptic depressor responses in the NTS and CVLM and pressor responses in the RVLM, and a recognition site for L-DOPA functions tonically to activate depressor neurons in the NTS and CVLM and pressor neurons in the RVLM.
Gene_expression (produces) of L-DOPA in neurons associated with medulla and rostral ventrolateral medulla
16) Confidence 0.33 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532212 Disease Relevance 0 Pain Relevance 0.78
Perineural gp120/hCD4 and ddC produce differential effects on thermal thresholds
Gene_expression (produce) of ddC
17) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.32 Pain Relevance 0.07
MCP1 immunopositive neurons were also present in the DRG of animals treated with both gp120/hCD4 and ddC combined (Fig. 6C) as previously observed [15].
Gene_expression (present) of ddC in neurons associated with dorsal root ganglion
18) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.78 Pain Relevance 0.26
One possible mechanism that has been suggested for the additive effect of the ddC is that this compound quite often results in mitochondrial dysfunction.
Gene_expression (effect) of ddC associated with parkinson's disease
19) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.04 Pain Relevance 0.59
Sensory neurons in DRG derived from gp120/hCD4 and ddC treated rodents (n = 6) displayed similar numbers of neurons that bound IB4 and were CCR2 immunopositive (51.3 ± 1%).


Gene_expression (rodents) of ddC in IB4 associated with dorsal root ganglion
20) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.48 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox