INT53063

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 3.23
Pain Relevance 9.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
spinal 2
frontal cortex 2
hippocampus 2
neuronal 1
neurons 1
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 50 100.00 Very High Very High Very High
excitatory amino acid 14 100.00 Very High Very High Very High
tolerance 5 100.00 Very High Very High Very High
Antinociceptive 5 100.00 Very High Very High Very High
antagonist 7 99.96 Very High Very High Very High
Pain 6 99.96 Very High Very High Very High
gABA 48 99.80 Very High Very High Very High
Morphine 32 99.80 Very High Very High Very High
withdrawal 11 99.74 Very High Very High Very High
intrathecal 2 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 99.96 Very High Very High Very High
INFLAMMATION 13 98.08 Very High Very High Very High
Urological Neuroanatomy 4 96.32 Very High Very High Very High
Convulsion 299 95.92 Very High Very High Very High
Epilepsy 124 81.76 Quite High
Absence Epilepsy 36 77.52 Quite High
Nociception 3 77.20 Quite High
Partial Seizures 140 49.00 Quite Low
Poisoning 1 36.48 Quite Low
Dentatorubro-pallidoluysian Atrophy 76 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced descending modulation appeared to be mediated by changes in the activation of the NMDA excitatory amino acid receptor.
Positive_regulation (activation) of NMDA excitatory amino acid receptor associated with excitatory amino acid
1) Confidence 0.70 Published 2000 Journal Neuroreport Section Abstract Doc Link 10884043 Disease Relevance 0.31 Pain Relevance 0.34
We conclude from these data that spinal interneurons which synapse with sympathetic preganglionic neurons can be activated through multiple subtypes of excitatory amino acid receptor, including both ionotropic and metabotropic receptors.
Positive_regulation (activated) of excitatory amino acid receptor in neurons associated with excitatory amino acid
2) Confidence 0.47 Published 1994 Journal Neuroscience Section Abstract Doc Link 7816200 Disease Relevance 0 Pain Relevance 0.29
These signals were sensitive to excitatory amino acid receptor antagonists but not to gamma-aminobutyric acid-A (GABAA) receptor antagonists. 6.
Neg (not) Positive_regulation (sensitive) of excitatory amino acid receptor associated with antagonist and excitatory amino acid
3) Confidence 0.47 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8836247 Disease Relevance 0 Pain Relevance 0.26
It is well known that neuroplasticity processes depend on the activation of the NMDA type of excitatory amino acid receptor.
Positive_regulation (activation) of excitatory amino acid receptor associated with excitatory amino acid
4) Confidence 0.35 Published 1993 Journal Brain Res. Section Abstract Doc Link 8094314 Disease Relevance 0.46 Pain Relevance 0.13
Long-term morphine infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (GTs), GLAST, GLT-1, and EAAC1, expression in the rat spinal cord dorsal horn.
Positive_regulation (induced) of EAAC1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, spinal cord and morphine
5) Confidence 0.35 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.62
Cell surface biotinylation and immunoblot analysis showed that morphine withdrawal produced an increase in GLT1 expression rather than EAAC1 (excitatory amino acids carrier 1), a neuronal subtype, at the cultured neuronal cell surface, whereas no significant change was observed in that of cultured astrocytes.
Positive_regulation (increase) of EAAC1 in neuronal associated with withdrawal, excitatory amino acid and morphine
6) Confidence 0.28 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.32
The inflammation-induced dynamic changes in descending modulation appeared to be correlated with changes in the activation of the N-methyl--aspartate (NMDA) excitatory amino acid receptor.
Positive_regulation (activation) of excitatory amino acid receptor associated with inflammation and excitatory amino acid
7) Confidence 0.23 Published 2002 Journal Pain Section Abstract Doc Link 12031790 Disease Relevance 0.88 Pain Relevance 0.99
BACKGROUND: Drugs that block spinal excitatory amino acid receptor activation may prevent pain after surgery.
Positive_regulation (activation) of spinal excitatory amino acid receptor in spinal associated with pain and excitatory amino acid
8) Confidence 0.19 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10910500 Disease Relevance 0.17 Pain Relevance 0.55
Here we show that the downregulation of spinal GTs (EAAC1 and GLT-1) induced by a 6-day intrathecal morphine (10 microg, twice daily) treatment regimen was prevented by co-administration of morphine with 2',5'-dideoxyadenosine (ddA, 1 microg, a broad adenylyl cyclase inhibitor) or H89 (10 microg, a selective protein kinase A inhibitor).
Positive_regulation (induced) of EAAC1 in spinal associated with morphine and intrathecal
9) Confidence 0.17 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694265 Disease Relevance 0.06 Pain Relevance 0.74
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
10) Confidence 0.07 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
11) Confidence 0.07 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (regulation) of EAAC-1 in hippocampus associated with glutamate, gaba, urological neuroanatomy and hippocampus
12) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of EAAC-1 in hippocampus associated with glutamate, gaba, urological neuroanatomy and hippocampus
13) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91

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