INT53065

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 16.39
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
neuronal 2
liver 2
bone marrow 2
kidney 2
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 15 100.00 Very High Very High Very High
cva 37 98.76 Very High Very High Very High
cytokine 34 98.60 Very High Very High Very High
Inflammation 22 96.92 Very High Very High Very High
rheumatoid arthritis 52 96.00 Very High Very High Very High
medulla 175 93.04 High High
headache 5 82.32 Quite High
methotrexate 1 78.48 Quite High
visual analogue scale 4 78.04 Quite High
cINOD 2 76.76 Quite High
Disease Link Frequency Relevance Heat
Anaemia 131 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
Malignant Neoplastic Disease 2 100.00 Very High Very High Very High
Injury 90 99.56 Very High Very High Very High
Cancer 43 99.56 Very High Very High Very High
Necrosis 6 99.36 Very High Very High Very High
Cv General 3 Under Development 37 98.76 Very High Very High Very High
Chronic Renal Failure 16 98.34 Very High Very High Very High
Hypoxia 133 97.84 Very High Very High Very High
INFLAMMATION 29 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As production of EPO is generally suppressed following injury, administration of exogenous EPO seems to be a valid approach in this context.
Negative_regulation (suppressed) of Gene_expression (production) of EPO associated with injury
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.60 Pain Relevance 0
Pain after subcutaneous injection of recombinant human erythropoietin: does Emla cream help?
Negative_regulation (Pain) of Gene_expression (injection) of erythropoietin associated with pain
2) Confidence 0.41 Published 1994 Journal Nephrol. Dial. Transplant. Section Title Doc Link 7816294 Disease Relevance 0.73 Pain Relevance 1.06
Anemia is common in chronic kidney disease (CKD) and although the cause is usually multifactorial, it is primarily related to the lack of erythropoietin (EPO) production.
Negative_regulation (lack) of Gene_expression (production) of erythropoietin in kidney associated with chronic renal failure and anaemia
3) Confidence 0.41 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.83 Pain Relevance 0
Relationship between Epo, EpoR and CD131 immunostaining and organ failure
Negative_regulation (Relationship) of Gene_expression (immunostaining) of Epo
4) Confidence 0.39 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.30 Pain Relevance 0.25
Relationship between Epo, EpoR, CD131 and neuroprotection

(i) Axonal injury, astrogliosis and neuronal chromatolysis

Negative_regulation (Relationship) of Gene_expression (neuroprotection) of Epo in neuronal associated with injury
5) Confidence 0.39 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.21 Pain Relevance 0.08
Relationship between Epo, EpoR and CD131 immunostaining and vascular permeability and haemorrhage
Negative_regulation (Relationship) of Gene_expression (immunostaining) of Epo associated with cva
6) Confidence 0.39 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.44 Pain Relevance 0.19
Relationship between Epo, EpoR and CD131 immunostaining and organ failure
Negative_regulation (failure) of Gene_expression (immunostaining) of Epo
7) Confidence 0.39 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.31 Pain Relevance 0.24
Relationship between Epo, EpoR and CD131 immunostaining, parasite load and cerebral sequestration
Negative_regulation (Relationship) of Gene_expression (immunostaining) of Epo
8) Confidence 0.39 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.48 Pain Relevance 0.04
Why does rhEpo fail to improve maximal oxygen uptake during acute severe hypoxia?
Negative_regulation (does) of Gene_expression (fail) of rhEpo associated with hypoxia
9) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.76 Pain Relevance 0
The observation that cyclosporine-based immunosuppression inhibits EPO production after liver transplantation [22] further warrants the application of EPO for hepatic growth support.
Negative_regulation (inhibits) of Gene_expression (production) of EPO in liver
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.54 Pain Relevance 0
Third, the erythropoietin production in response to anemia is relatively impaired.
Negative_regulation (impaired) of Gene_expression (production) of erythropoietin associated with anaemia
11) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826733 Disease Relevance 3.15 Pain Relevance 0.97
Cancer-related anemia often develops from the infiltration of marrow by malignant cells, impaired hemoglobin (Hb) production related to chemotherapy or radiation therapy, iron deficiency, or low endogenous erythropoietin levels.
Negative_regulation (impaired) of Gene_expression (production) of erythropoietin associated with malignant neoplastic disease, anaemia and cancer
12) Confidence 0.05 Published 2003 Journal Cancer Nurs Section Abstract Doc Link 15025412 Disease Relevance 1.54 Pain Relevance 0.08
Cancer-related anemia often develops from the infiltration of marrow by malignant cells, impaired hemoglobin (Hb) production related to chemotherapy or radiation therapy, iron deficiency, or low endogenous erythropoietin levels.
Negative_regulation (develops) of Gene_expression (production) of erythropoietin associated with malignant neoplastic disease, anaemia and cancer
13) Confidence 0.05 Published 2003 Journal Cancer Nurs Section Abstract Doc Link 15025412 Disease Relevance 1.54 Pain Relevance 0.08
These rabbits all had poor renal function, which is similar to clinical human patients due to a decrease in erythropoietin production by the damaged kidneys [37].
Negative_regulation (decrease) of Gene_expression (production) of erythropoietin
14) Confidence 0.03 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014707 Disease Relevance 1.07 Pain Relevance 0
It is associated with the excessive release of cytokines such as interleukin-1, tumor necrosis factor, and interferons, which interfere with the production of endogenous erythropoietin and inhibit erythroid bone marrow production [8,9].
Negative_regulation (interfere) of Gene_expression (production) of erythropoietin in bone marrow associated with necrosis, cancer and cytokine
15) Confidence 0.02 Published 2007 Journal Trials Section Body Doc Link PMC1831793 Disease Relevance 1.90 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox