INT53069

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Context Info
Confidence 0.23
First Reported 1993
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.49
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tac4)
Anatomy Link Frequency
striatum 10
neurons 2
Tac4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 9 100.00 Very High Very High Very High
Dopamine 22 99.68 Very High Very High Very High
substance P 3 98.12 Very High Very High Very High
Neuropeptide 4 97.32 Very High Very High Very High
Enkephalin 12 97.08 Very High Very High Very High
Dynorphin 2 94.52 High High
Eae 1 93.76 High High
Intracerebroventricular 2 93.44 High High
Sciatic nerve 1 92.36 High High
antagonist 1 83.52 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 98.68 Very High Very High Very High
Injury 2 92.92 High High
Decapitation 1 76.44 Quite High
Neuropathic Pain 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High
Causalgia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide messenger RNA expression in the 6-hydroxydopamine-lesioned rat striatum reinnervated by fetal dopaminergic transplants: differential effects of the grafts on preproenkephalin, preprotachykinin and prodynorphin messenger RNA levels.
Regulation (effects) of Transcription (levels) of preprotachykinin in striatum associated with neuropeptide
1) Confidence 0.23 Published 1993 Journal Neuroscience Section Title Doc Link 8115038 Disease Relevance 0.08 Pain Relevance 0.46
The experiments described in the present study approached nerve injury from both a biochemical and anatomical perspective by monitoring changes in expression of preprotachykinin (PPT) mRNA encoding the prototypic tachykinin substance P and related peptide species in neurons of the rat dorsal root ganglia (DRG) following unilateral chronic constriction injury of the sciatic nerve.
Regulation (changes) of Transcription (expression) of preprotachykinin in neurons associated with nervous system injury, eae, injury, sciatic nerve and substance p
2) Confidence 0.20 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.41 Pain Relevance 0.25
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Regulation (dysregulated) of Transcription (expression) of preprotachykinin in STR associated with dopamine
3) Confidence 0.12 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.62
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Regulation (influences) of Transcription (expression) of preprotachykinin in STR associated with dopamine
4) Confidence 0.12 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.62
To this end, changes in mRNA levels of preproenkephalin-A, preproenkephalin-B, and preprotachykinin were determined in the rat striatum following chronic drug treatment for 14 days, using quantitative in situ hybridization.
Regulation (changes) of Transcription (levels) of preprotachykinin in striatum
5) Confidence 0.11 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.28
The effects of lowered serotonin (5-hydroxytryptamine; 5-HT) neurotransmission on preprotachykinin (PPT) and preproenkephalin (PPE) mRNA levels were examined in subregions of the striatum.
Spec (examined) Regulation (effects) of Transcription (levels) of preprotachykinin in striatum associated with serotonin
6) Confidence 0.11 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.12

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