INT5307

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 12
Speculated 16
Reported most in Abstract
Documents 87
Total Number 103
Disease Relevance 78.71
Pain Relevance 43.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
dorsal root ganglia 6
brain 4
spinal cord 4
spinal 3
monocytes 3
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 400 100.00 Very High Very High Very High
cytokine 392 100.00 Very High Very High Very High
Pain 194 100.00 Very High Very High Very High
allodynia 117 100.00 Very High Very High Very High
Hyperalgesia 62 100.00 Very High Very High Very High
Spinal cord 58 100.00 Very High Very High Very High
COX2 32 100.00 Very High Very High Very High
Inflammatory mediators 32 100.00 Very High Very High Very High
Paracetamol 31 100.00 Very High Very High Very High
Snapping jaw 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 446 100.00 Very High Very High Very High
Neuropathic Pain 266 100.00 Very High Very High Very High
Pain 182 100.00 Very High Very High Very High
Pressure And Volume Under Development 175 100.00 Very High Very High Very High
Necrosis 142 100.00 Very High Very High Very High
Cancer 141 100.00 Very High Very High Very High
Hyperalgesia 115 100.00 Very High Very High Very High
Obesity 56 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 22 100.00 Very High Very High Very High
Emergencies 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCX 4016, at equimolar doses for aspirin, i.e., 18.6, 55.8 and 186 mg/kg, respectively, did not cause any changes in exudate IL-1beta or TNF-alpha levels.
Neg (not) Regulation (changes) of TNF-alpha associated with aspirin
1) Confidence 0.62 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320862 Disease Relevance 0.31 Pain Relevance 0.86
Presently, we demonstrate that similar to alpha 2-adrenergic activation, TNF alpha regulation of NE release in a region of the brain rich in noradrenergic nerve terminals, is dependent upon the frequency of electrical stimulation applied to the hippocampal slice.
Regulation (regulation) of TNF alpha in nerve
2) Confidence 0.61 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357451 Disease Relevance 0.30 Pain Relevance 0.37
It is important to note, however, that spinal PGE2 and TNF-alpha proved to be differently affected by pharmacological treatments able to fully abolish the hyperalgesia.


Regulation (affected) of TNF-alpha in spinal
3) Confidence 0.61 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17377112 Disease Relevance 0.05 Pain Relevance 0
In addition, we investigated whether different analgesic drugs orally administered at antihyperalgesic doses were able to prevent the changes in PGE2 and TNF-alpha spinal levels associated with hindpaw inflammation.
Regulation (changes) of TNF-alpha in spinal associated with antihyperalgesic, inflammation and analgesic
4) Confidence 0.61 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17377112 Disease Relevance 0.58 Pain Relevance 0.38
Neither of these inhibitors, however, affected tumor necrosis factor alpha, prostaglandin E2 or epinephrine hyperalgesia.
Neg (Neither) Regulation (affected) of tumor necrosis factor alpha associated with necrosis, hyperalgesia and cancer
5) Confidence 0.61 Published 2006 Journal Pain Section Abstract Doc Link 16472913 Disease Relevance 1.58 Pain Relevance 1.02
in DRG of sham-operated rats after even 14 days could be explained by belated regulation of TNF-?
Regulation (regulation) of TNF
6) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.66 Pain Relevance 0.37
The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw.
Regulation (effects) of tumor necrosis factor-alpha in paw associated with pain, necrosis, inflammation and cancer
7) Confidence 0.60 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15155307 Disease Relevance 0.93 Pain Relevance 0.70
However, iNOS inhibition aggravated the LPS-induced changes in TNF alpha, all biochemical factors, and the hepatic and cardiac tissue damage.
Regulation (changes) of TNF alpha
8) Confidence 0.51 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821434 Disease Relevance 0.67 Pain Relevance 0.07
Effect of temporomandibular joint arthrocentesis on synovial fluid mediator level of tumor necrosis factor-alpha: implications for treatment outcome.
Regulation (Effect) of tumor necrosis factor-alpha in synovial fluid associated with necrosis, snapping jaw and cancer
9) Confidence 0.47 Published 2000 Journal Int J Oral Maxillofac Surg Section Title Doc Link 10970078 Disease Relevance 1.70 Pain Relevance 1.25
CONCLUSION: Acute myocardial ischemia could cause up-regulation of TNF-alpha in lungs, which is likely to be mediated by neural mechanisms.
Regulation (regulation) of TNF-alpha in lungs
10) Confidence 0.45 Published 2008 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Body Doc Link 19111113 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The data of the study clearly indicate a role for tumor necrosis factor alpha in the studied behavior changes after experimental disc herniation in the rat.
Regulation (role) of tumor necrosis factor alpha
11) Confidence 0.45 Published 2003 Journal Spine Section Body Doc Link 12897484 Disease Relevance 0 Pain Relevance 0
The goal of this study was to determine whether responses of dorsal root ganglion (DRG) neurons to exogenous tumor necrosis factor alpha (TNF-alpha) are altered in a chronically compressed DRG (CCD) injury model.
Spec (whether) Regulation (altered) of tumor necrosis factor alpha in DRG associated with ganglion cysts, dorsal root ganglion, necrosis, cancer and injury
12) Confidence 0.45 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205160 Disease Relevance 1.02 Pain Relevance 0.42
The goal of this study was to determine whether responses of dorsal root ganglion (DRG) neurons to exogenous tumor necrosis factor alpha (TNF-alpha) are altered in a chronically compressed DRG (CCD) injury model.
Spec (whether) Regulation (altered) of TNF-alpha in DRG associated with ganglion cysts, dorsal root ganglion, necrosis, cancer and injury
13) Confidence 0.45 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205160 Disease Relevance 1.02 Pain Relevance 0.42
Reports on the effect of acetaminophen in vivo on TNF-alpha transcript concentrations and serum TNF-alpha concentrations, under different experimental, or clinical conditions have yielded controversial results.
Regulation (effect) of TNF-alpha transcript associated with paracetamol
14) Confidence 0.45 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.28 Pain Relevance 0.31
Reports on the effect of acetaminophen in vivo on TNF-alpha transcript concentrations and serum TNF-alpha concentrations, under different experimental, or clinical conditions have yielded controversial results.
Regulation (effect) of TNF-alpha associated with paracetamol
15) Confidence 0.45 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.28 Pain Relevance 0.31
Unlike paracetamol, which increased exudate TNF-alpha level, NCX 701 had no effect on TNF-alpha level in the exudates.
Neg (no) Regulation (effect) of TNF-alpha associated with paracetamol
16) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320862 Disease Relevance 0.07 Pain Relevance 0.89
In the present study, we have tested the effect of acute application of TNF-alpha on voltage-gated potassium, calcium and sodium channel currents as well as its influence on membrane conductance in isolated rat DRG neurons.
Regulation (effect) of TNF-alpha in neurons associated with dorsal root ganglion and sodium channel
17) Confidence 0.45 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18314270 Disease Relevance 0.95 Pain Relevance 0.61
Responses to intravenous TNF-alpha were not affected by vagotomy but were reduced by mid-collicular decerebration.
Neg (not) Regulation (affected) of TNF-alpha
18) Confidence 0.45 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12626358 Disease Relevance 0 Pain Relevance 0.24
CONCLUSION: EA can effectively suppress CCI-induced up-regulation of expression of spinal GFAP, TNF-alpha mRNA and IL-1beta mRNA, which may contribute to its effect in reducing mechanical allodynia and thermal hyperalgesia in neuropathic pain rats.


Regulation (regulation) of TNF-alpha mRNA in spinal
19) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Body Doc Link 20458900 Disease Relevance 0.16 Pain Relevance 0
Neuronal-associated tumor necrosis factor (TNF alpha): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration.
Regulation (role) of TNF alpha in Neuronal associated with necrosis, antidepressant and cancer
20) Confidence 0.45 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9357451 Disease Relevance 0.39 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox