INT53070

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 1994
Last Reported 2009
Negated 5
Speculated 8
Reported most in Abstract
Documents 15
Total Number 24
Disease Relevance 9.35
Pain Relevance 13.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) aging (Rtn4) endoplasmic reticulum (Rtn4)
plasma membrane (Rtn4) protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
dorsal root ganglion 11
neurons 6
funnel 1
nerve 1
Rtn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 62 100.00 Very High Very High Very High
diclofenac 9 100.00 Very High Very High Very High
carbamazepine 9 100.00 Very High Very High Very High
Endep 9 100.00 Very High Very High Very High
cINOD 5 100.00 Very High Very High Very High
sodium channel 100 99.92 Very High Very High Very High
Inflammation 24 99.80 Very High Very High Very High
analgesia 14 99.58 Very High Very High Very High
Potency 1 99.44 Very High Very High Very High
local anesthetic 4 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 29 100.00 Very High Very High Very High
Htlv Types I And Ii 6 100.00 Very High Very High Very High
Pain 23 99.28 Very High Very High Very High
Neuropathic Pain 48 99.12 Very High Very High Very High
Ganglion Cysts 275 98.96 Very High Very High Very High
Nervous System Injury 57 98.12 Very High Very High Very High
Injury 270 93.84 High High
Targeted Disruption 9 92.92 High High
Nociception 16 90.64 High High
Rheumatoid Arthritis 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report the effects of carbamazepine (CBZ) and amitriptyline (ATL) on tetrodotoxin-resistant (TTX-R) Na' channels expressed on immature rat TG neurons.
Regulation (effects) of TTX-R in neurons associated with tetrodotoxin, trigeminal ganglion, endep and carbamazepine
1) Confidence 0.22 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365687 Disease Relevance 1.05 Pain Relevance 1.10
Strong 1 s hyperpolarizing prepulses relieved most of the fast channel block but had much less effect on blocked TTX-R channels.
Regulation (effect) of TTX-R
2) Confidence 0.09 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9159498 Disease Relevance 0.07 Pain Relevance 0.25
The present study shows that CCD treatment significantly down-regulates both the TTX-R and TTX-S Na+currents in the small DRG neurons.
Regulation (regulates) of TTX-R in neurons associated with dorsal root ganglion
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 1.39 Pain Relevance 1.68
We investigated its effect on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na(+) currents in rat dorsal root ganglion (DRG) neurons to elucidate the mechanisms underlying the above effects.
Spec (investigated) Regulation (effect) of TTX-R in DRG associated with ganglion cysts, dorsal root ganglion and tetrodotoxin
4) Confidence 0.05 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11049911 Disease Relevance 0.43 Pain Relevance 0.56
The effects of riluzole, a neuroprotective drug, on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium channels in rat dorsal root ganglion neurons were studied using the whole-cell patch clamp technique.
Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin, root ganglion neuron and sodium channel
5) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262334 Disease Relevance 0.10 Pain Relevance 0.68
The present study was undertaken to investigate whether celecoxib could regulate the tetrodotoxin-resistant (TTX-R) sodium channel current in rat dorsal root ganglia (DRG) and whether prostaglandin E2 (PGE2) and calcitonin gene-related protein (CGRP) were involved in celecoxib's analgesia during acute incisional pain.
Regulation (regulate) of TTX-R in dorsal root ganglia associated with pain, tetrodotoxin, sodium channel and analgesia
6) Confidence 0.04 Published 2008 Journal Brain Res. Section Abstract Doc Link 18400213 Disease Relevance 0.24 Pain Relevance 0.51
The differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) single sodium channel currents in rat dorsal root ganglion (DRG) neurons were investigated using the outside-out configuration of patch-clamp technique.
Spec (investigated) Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, tetrodotoxin and sodium channel
7) Confidence 0.04 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814900 Disease Relevance 0.10 Pain Relevance 0.56
In this study, the down-regulation of the TTX-R currents are similar to those observed in the nerve injury model, but not the inflammation model in which up-regulated [1].
Regulation (regulation) of TTX-R in nerve associated with nervous system injury and inflammation
8) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.83 Pain Relevance 0.58
The present study investigated alterations of TTX-R and TTX-S Na+ currents in the small DRG neurons after DRG somata compression (CCD treatment) and compared the different effects of DRG somata compression and the axons injury (CCI treatment) on the Na+ currents.
Spec (investigated) Regulation (alterations) of TTX-R in neurons associated with dorsal root ganglion, eae and injury
9) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.99 Pain Relevance 0.45
Here, we investigated the effects of resveratrol on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ currents in rat dorsal root ganglion (DRG) neurons.
Spec (investigated) Regulation (effects) of TTX-R in DRG associated with ganglion cysts, dorsal root ganglion and tetrodotoxin
10) Confidence 0.02 Published 2005 Journal Brain Res. Section Abstract Doc Link 15910771 Disease Relevance 0.45 Pain Relevance 0.53
To elucidate the local anesthetic mechanism of diphenhydramine, its effects on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were examined by the whole-cell voltage clamp method.
Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, tetrodotoxin and local anesthetic
11) Confidence 0.02 Published 2000 Journal Brain Res. Section Abstract Doc Link 11036158 Disease Relevance 0.17 Pain Relevance 0.39
It shifted the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but had little effect on that for TTX-R sodium currents.
Neg (little) Regulation (effect) of TTX-R
12) Confidence 0.02 Published 2000 Journal Brain Res. Section Abstract Doc Link 11036158 Disease Relevance 0.16 Pain Relevance 0.41
The modulation of tetrodotoxin-sensitive (TTX-S) and slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons by ATP was studied using the whole-cell patch-clamp method.
Regulation (modulation) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin and root ganglion neuron
13) Confidence 0.02 Published 2003 Journal Brain Res. Section Abstract Doc Link 12644260 Disease Relevance 0.17 Pain Relevance 0.29
We examined the effects of celecoxib on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na(+) currents in acutely dissociated rat dorsal root ganglion neurons.
Spec (examined) Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin and root ganglion neuron
14) Confidence 0.02 Published 2007 Journal Brain Res. Section Abstract Doc Link 17359944 Disease Relevance 0.54 Pain Relevance 0.57
The effects of arachidonic acid on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were assessed using the whole-cell patch-clamp method.
Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin and root ganglion neuron
15) Confidence 0.01 Published 2002 Journal Brain Res. Section Abstract Doc Link 12231233 Disease Relevance 0.17 Pain Relevance 0.29
We examined the effect of anandamide on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ currents in rat dorsal root ganglion neurons.
Spec (examined) Regulation (effect) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin and root ganglion neuron
16) Confidence 0.01 Published 2005 Journal Brain Res. Section Abstract Doc Link 16256960 Disease Relevance 0.46 Pain Relevance 0.84
To elucidate an involvement of Na(+) channels in the eugenol-induced analgesia we investigated the effects of eugenol on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na(+) currents in acutely dissociated rat dorsal root ganglion neurons.
Spec (investigated) Regulation (effects) of TTX-R in neurons associated with ganglion cysts, tetrodotoxin, root ganglion neuron and analgesia
17) Confidence 0.01 Published 2008 Journal Brain Res. Section Abstract Doc Link 18824159 Disease Relevance 0.53 Pain Relevance 0.73
The effects of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), on the fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were investigated using the whole-cell patch-clamp method.
Spec (investigated) Regulation (effects) of TTX-R in dorsal root ganglion associated with ganglion cysts, tetrodotoxin, inflammation, root ganglion neuron, cinod and diclofenac
18) Confidence 0.01 Published 2003 Journal Brain Res. Section Abstract Doc Link 14604780 Disease Relevance 0.27 Pain Relevance 0.73
TTX-R/NaV1.8 is an attractive therapeutic drug target for inflammatory and neuropathic pain on the basis of its specific distribution in sensory neurones and its modulation by inflammatory mediators.
Regulation (target) of TTX-R associated with inflammatory mediators, inflammation and neuropathic pain
19) Confidence 0.01 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975698 Disease Relevance 0.83 Pain Relevance 0.85
Studies in phenylephrine-contracted prostatic tissue showed no significant difference in alpha 1-adrenoceptor antagonist potency between racemic doxazosin, R-doxazosin and S-doxazosin (pA2 values were 8.43 +/- 0.28, 8.64 +/- 0.56 and 8.75 +/- 0.38, respectively).
Regulation (values) of R-doxazosin associated with antagonist and potency
20) Confidence 0.00 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8905340 Disease Relevance 0 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox