INT53080

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 42
Total Number 43
Disease Relevance 23.58
Pain Relevance 14.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
platelet 3
brain 2
spinal cord 1
peritoneal macrophages 1
Kupffer cells 1
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 68 100.00 Very High Very High Very High
cOX1 21 100.00 Very High Very High Very High
cINOD 126 99.96 Very High Very High Very High
COX2 64 99.88 Very High Very High Very High
Inflammation 201 99.84 Very High Very High Very High
Paracetamol 38 99.48 Very High Very High Very High
Inflammatory response 27 99.30 Very High Very High Very High
metalloproteinase 14 99.14 Very High Very High Very High
Hyperalgesia 9 98.86 Very High Very High Very High
aspirin 54 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 183 99.96 Very High Very High Very High
INFLAMMATION 267 99.84 Very High Very High Very High
Injury 16 99.64 Very High Very High Very High
Cardiovascular Disease 10 99.60 Very High Very High Very High
Cancer 170 99.04 Very High Very High Very High
Hyperalgesia 18 98.86 Very High Very High Very High
Metastasis 7 98.62 Very High Very High Very High
Peptic Ulcer 8 98.24 Very High Very High Very High
Hyperplasia 3 98.16 Very High Very High Very High
Inflammatory Bowel Disease 36 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGHS1 and PGHS2 coexist in the vasculature and in macrophages, and are upregulated together in inflammatory tissues such as rheumatoid synovia and atherosclerotic plaque.
Positive_regulation (upregulated) of PGHS1 in plaque associated with atherosclerotic plaque and inflammation
1) Confidence 0.42 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.39 Pain Relevance 0.44
METHODS: To address this question, we studied mice with targeted disruption of the COX-1 (Ptgs1) gene.
Positive_regulation (disruption) of Ptgs1
2) Confidence 0.37 Published 2001 Journal Kidney Int. Section Body Doc Link 11737606 Disease Relevance 0 Pain Relevance 0
The loss of specific enzyme-mediated radical generation is unsurprising, given the well-recognised suicidal nature of activated PGHS-1 [3].
Positive_regulation (activated) of PGHS-1
3) Confidence 0.32 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.07
The suicidal nature of PGHS-1 activation means that the period of activation is anticipated to be complete within ~1 min of AA addition [3].
Positive_regulation (activation) of PGHS-1
4) Confidence 0.32 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.04
PGHS-1 steady-state levels remained unchanged upon induction of acute or chronic epidermal hyperplasia by TPA and in papillomas and carcinomas generated by the initiation-promotion procedure, with 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter.
Neg (unchanged) Positive_regulation (unchanged) of PGHS-1 associated with non-genital cutaneous warts, carcinoma and hyperplasia
5) Confidence 0.29 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 0.89 Pain Relevance 0.26
While the development of selective inhibitors of inducible cyclooxygenase (COX)-2 (so called coxibs) has greatly reduced gastrointestinal side effects, the recent disappointment about a potential cardiovascular toxicity of COX-2-selective inhibitors has boosted interest in alternative targets.
Positive_regulation (inducible) of cyclooxygenase associated with toxicity
6) Confidence 0.26 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 16959219 Disease Relevance 0.52 Pain Relevance 0.55
Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide.
Positive_regulation (inducible) of cyclooxygenase in brain
7) Confidence 0.19 Published 1996 Journal Brain Res. Section Title Doc Link 8724976 Disease Relevance 0.17 Pain Relevance 0.29
Rather, the effects are mediated by the metabolism of diacylglycerol and the production of prostaglandins via the cyclooxygenase pathway, leading to activation of the cAMP-dependent protein kinase subsequent to prostanoid receptor activation.
Positive_regulation (leading) of cyclooxygenase
8) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196566 Disease Relevance 0.15 Pain Relevance 0.56
The identification and characterization of an inducible cyclooxygenase isoform has led to important studies evaluating the role of this enzyme in inflammation, neoplasia, and NSAID-induced gastrointestinal injury.
Positive_regulation (inducible) of cyclooxygenase associated with inflammation, cancer, injury and cinod
9) Confidence 0.16 Published 1996 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 9229572 Disease Relevance 0.59 Pain Relevance 0.22
Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers.
Positive_regulation (selective) of cyclooxygenase associated with cinod and peptic ulcer
10) Confidence 0.15 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373427 Disease Relevance 0.38 Pain Relevance 0.10
Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice.
Positive_regulation (induction) of cyclooxygenase in spinal cord associated with spinal cord
11) Confidence 0.15 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924902 Disease Relevance 0.59 Pain Relevance 0.60
This year many papers have been published speculating about those NSAIDs that are reported to selectively inhibit the isoform of the cyclooxygenase enzyme that is induced in inflammatory conditions (Cox-2) rather than that associated with normal physiologic function (Cox-1).
Positive_regulation (induced) of cyclooxygenase associated with inflammation and cinod
12) Confidence 0.12 Published 1997 Journal Curr Opin Rheumatol Section Abstract Doc Link 9204251 Disease Relevance 0.56 Pain Relevance 0.52
Although the mechanism of action of acetaminophen (AAP) is not fully understood, some studies suggest that AAP and phenacetin (PHE) are selective cyclooxygenase (COX)-3 inhibitors.
Positive_regulation (selective) of cyclooxygenase associated with paracetamol
13) Confidence 0.11 Published 2007 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 17606472 Disease Relevance 0 Pain Relevance 0.59
Aspirin is effective in the therapy of cardiovascular diseases, because it causes acetylation of cyclooxygenase 1 (COX-1) leading to irreversible inhibition of platelets.
Positive_regulation (acetylation) of cyclooxygenase 1 in platelets associated with aspirin, cardiovascular disease and cox1
14) Confidence 0.11 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16179345 Disease Relevance 0.31 Pain Relevance 0.40
During the inflammatory process, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) were increased in mouse peritoneal macrophages.
Positive_regulation (increased) of cyclooxygenase in peritoneal macrophages associated with inflammation
15) Confidence 0.09 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 19051342 Disease Relevance 0.53 Pain Relevance 0.28
Numerous anti-inflammatory agents have been shown to exert chemopreventive activity by targeting cyclooxygenase (COX)-2, a rate-limiting enzyme involved in the inflammatory process.
Positive_regulation (targeting) of cyclooxygenase associated with inflammation
16) Confidence 0.08 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.44 Pain Relevance 0.21
However, it has also been established that a variety of their anti-inflammatory effects are independent of cyclooxygenase.
Neg (independent) Positive_regulation (independent) of cyclooxygenase associated with inflammation
17) Confidence 0.07 Published 2006 Journal Exp. Hematol. Section Abstract Doc Link 16569588 Disease Relevance 0.52 Pain Relevance 0.66
In vitro, paracetamol inhibits cyclooxygenase (COX)-1 and -2 in high concentrations but stimulates in low doses.
Positive_regulation (stimulates) of cyclooxygenase
18) Confidence 0.07 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 12503027 Disease Relevance 0.09 Pain Relevance 0.77
However, recent evidence from our laboratory has demonstrated that hepato-protective factors, such as interleukin (IL)-10 and cyclooxygenase-derived mediators, are also upregulated in response to hepatic damage to help protect against exacerbated injury, and Kupffer cells have been suggested to be a source of these modulatory factors.
Positive_regulation (upregulated) of cyclooxygenase-derived in Kupffer cells associated with injury
19) Confidence 0.06 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482232 Disease Relevance 0.33 Pain Relevance 0.37
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
Positive_regulation (nonselective) of cyclooxygenase in poly
20) Confidence 0.06 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.46 Pain Relevance 0.22

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