INT53081

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 15.83
Pain Relevance 10.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 6
microglial cells 6
RAW 264 4
skin 4
spinal cord 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 100.00 Very High Very High Very High
COX2 26 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
Nerve growth factor 5 100.00 Very High Very High Very High
cINOD 28 99.80 Very High Very High Very High
bradykinin 1 99.80 Very High Very High Very High
Analgesic 83 99.58 Very High Very High Very High
Endocannabinoid 2 99.08 Very High Very High Very High
Hippocampus 5 98.88 Very High Very High Very High
agonist 66 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 84 100.00 Very High Very High Very High
Cancer 24 100.00 Very High Very High Very High
Polyps 3 99.96 Very High Very High Very High
Hyperplasia 4 99.90 Very High Very High Very High
Adhesions 2 99.56 Very High Very High Very High
Herpes Simplex Virus 3 99.52 Very High Very High Very High
Stress 3 99.40 Very High Very High Very High
Disease 18 98.96 Very High Very High Very High
Familial Adenomatous Polyposis 1 98.64 Very High Very High Very High
Colon Cancer 5 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using lipopolysaccharide-treated RAW 264.7 cells, down-regulation of cyclooxygenase-2 expression was found to be one of the cellular action mechanisms of anti-inflammation by Sedum kamtschaticum.
Negative_regulation (down-regulation) of Gene_expression (expression) of cyclooxygenase-2 in RAW 264 associated with inflammation
1) Confidence 0.59 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15013209 Disease Relevance 0.55 Pain Relevance 0.30
Expression of PGHS-2 is inhibited by antiinflammatory glucocorticoids, lending further support to the hypothesis that this enzyme produces prostaglandins involved in inflammation.
Negative_regulation (inhibited) of Gene_expression (Expression) of PGHS-2 associated with inflammation
2) Confidence 0.56 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.49 Pain Relevance 0.56
Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929.
Negative_regulation (suppresses) of Gene_expression (expressions) of cyclooxygenase-2 in fibroblast associated with cox2
3) Confidence 0.55 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14646256 Disease Relevance 0.28 Pain Relevance 0.34
Repeated applications of TPA resulted in stationary hyperplasia and downregulation of PGHS-2 expression and prostaglandin levels, suggesting that the epidermis had adapted to the TPA stimulus.
Negative_regulation (downregulation) of Gene_expression (expression) of PGHS-2 in epidermis associated with hyperplasia
4) Confidence 0.54 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 1.05 Pain Relevance 0.21
Inhibitory effect of Angelicae Tenuissimae Radix on expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells.
Negative_regulation (effect) of Gene_expression (expressions) of cyclooxygenase-2 in microglial cells associated with cox2
5) Confidence 0.43 Published 2010 Journal Neurol. Res. Section Title Doc Link 20034447 Disease Relevance 0.09 Pain Relevance 0.32
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Negative_regulation (blocked) of Gene_expression (induction) of cyclooxygenase-2 in alveolar macrophages
6) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.50 Pain Relevance 0.55
SC suppressed production of nitric oxide and induction of iNOS and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
Negative_regulation (suppressed) of Gene_expression (production) of cyclooxygenase-2 in macrophages
7) Confidence 0.41 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18790036 Disease Relevance 0.21 Pain Relevance 0
These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions.
Negative_regulation (suppressing) of Gene_expression (expressions) of cyclooxygenase-2 associated with inflammation and analgesic
8) Confidence 0.40 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.32 Pain Relevance 0.29
The oral administration of the nonsteroidal anti-inflammatory drug sulindac inhibited the light-induced overexpression of cyclooxygenase-2 and oxidative stress-related genes in skin, and down-regulated smoke-induced genes involved in oxidative stress, removal of damaged proteins, inflammation, and immune response in lung.
Negative_regulation (inhibited) of Gene_expression (overexpression) of cyclooxygenase-2 in skin associated with stress, inflammation and cinod
9) Confidence 0.36 Published 2004 Journal FASEB J. Section Abstract Doc Link 15289447 Disease Relevance 0.73 Pain Relevance 0.15
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.
Negative_regulation (blocked) of Gene_expression (overexpression) of Cyclooxygenase-2 associated with cancer, familial adenomatous polyposis and cox2
10) Confidence 0.35 Published 1996 Journal Cancer Res. Section Title Doc Link 8653697 Disease Relevance 0.93 Pain Relevance 0.22
It was found that G168 showed much stronger inhibition against cyclooxygenase-2-mediated PGE2 production than the original molecule, BF6-6.
Negative_regulation (inhibition) of Gene_expression (production) of cyclooxygenase-2-mediated
11) Confidence 0.31 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 20091265 Disease Relevance 0.57 Pain Relevance 0.30
These results show that Armeniacae semen exerts anti-inflammatory and analgesic effects probably by suppression of cyclooxygenase-2 and inducible nitric oxide synthase expressions.
Negative_regulation (suppression) of Gene_expression (expressions) of cyclooxygenase-2 in semen associated with inflammation and analgesic
12) Confidence 0.28 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15744067 Disease Relevance 0.39 Pain Relevance 0.29
In the present study, we show that homologous disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by approximately 80%.
Negative_regulation (reduced) of Gene_expression (disruption) of Ptgs-2 associated with polyps
13) Confidence 0.27 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10987272 Disease Relevance 0.26 Pain Relevance 0.06
Inhibition of cyclooxygenase 2 synthesis suppresses Herpes simplex virus type 1 reactivation.
Negative_regulation (Inhibition) of Gene_expression (synthesis) of cyclooxygenase 2 associated with herpes simplex virus and cox2
14) Confidence 0.25 Published 2005 Journal J Ocul Pharmacol Ther Section Title Doc Link 15857277 Disease Relevance 0.54 Pain Relevance 0.31
Analyses at both cellular and molecular levels to a penetrating neocortical injury in mice that lack IL-1R1 demonstrated: diminished responsiveness of macrophages and microglia, deficient recruitment of peripheral macrophages, attenuated production of the vascular cell adhesion molecule-1 (VCAM-1), attenuated cyclooxygenase-2 production and attenuated levels of pro-inflammatory cytokine mRNAs.
Negative_regulation (attenuated) of Gene_expression (production) of cyclooxygenase-2 in macrophages associated with inflammation, injury, adhesions and cytokine
15) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.01 Pain Relevance 0.31
Drug treatment reduced the expression of the proinflammatory enzymes cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS).
Negative_regulation (reduced) of Gene_expression (expression) of cyclooxygenase 2 associated with cox2
16) Confidence 0.18 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.92 Pain Relevance 0.86
PEA significantly reduced the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in sciatic nerves and restored carrageenan-induced reductions of PPAR-alpha in the L4-L6 dorsal root ganglia (DRG).
Negative_regulation (reduced) of Gene_expression (expression) of cyclooxygenase-2 in dorsal root ganglia associated with sciatic nerve
17) Confidence 0.17 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.71 Pain Relevance 0.85
Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells.
Negative_regulation (suppresses) of Gene_expression (expressions) of cyclooxygenase-2 in microglial cells associated with cox2
18) Confidence 0.16 Published 2007 Journal Neurol. Res. Section Title Doc Link 17359643 Disease Relevance 0.18 Pain Relevance 0.18
Lack of functional TRPV1 did not inhibit development of histological evidence of bladder inflammation, or increased expression of mRNAs for nerve growth factor, endothelial nitric oxide synthase, cyclooxygenase-2 and bradykinin receptors in urothelium.
Negative_regulation (inhibit) of Gene_expression (expression) of cyclooxygenase-2 in nerve associated with nerve growth factor, inflammation and bradykinin
19) Confidence 0.16 Published 2008 Journal Pain Section Abstract Doc Link 18445509 Disease Relevance 0.79 Pain Relevance 0.54
In addition, GEE inhibited NO production and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) upon stimulation by lipopolysaccharide (LPS) in RAW264.7 macrophages.
Negative_regulation (inhibited) of Neg (NO) Gene_expression (production) of cyclooxygenase-2 in macrophages
20) Confidence 0.15 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17129693 Disease Relevance 0.24 Pain Relevance 0.20

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