INT53082

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 47
Total Number 48
Disease Relevance 25.39
Pain Relevance 11.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 13
skin 8
brain 4
semen 4
L929 4
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 152 100.00 Very High Very High Very High
COX2 50 100.00 Very High Very High Very High
cytokine 28 100.00 Very High Very High Very High
Inflammatory mediators 8 100.00 Very High Very High Very High
cOX1 4 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
bradykinin 1 99.80 Very High Very High Very High
substance P 1 99.76 Very High Very High Very High
cINOD 51 99.24 Very High Very High Very High
Analgesic 18 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 184 100.00 Very High Very High Very High
Cancer 183 99.80 Very High Very High Very High
Stomach Cancer 2 99.70 Very High Very High Very High
Carcinoma 8 99.52 Very High Very High Very High
Necrosis 8 99.48 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 6 99.44 Very High Very High Very High
Colorectal Cancer 37 99.40 Very High Very High Very High
Stress 23 99.40 Very High Very High Very High
Non-genital Cutaneous Warts 2 99.22 Very High Very High Very High
Hyperalgesia 13 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In papillomas and carcinomas, however, constitutive overexpression of PGHS-2 was found, with a large amount of prostaglandin E2 and prostaglandin F2 alpha.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PGHS-2 associated with non-genital cutaneous warts and carcinoma
1) Confidence 0.64 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 1.02 Pain Relevance 0.18
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase 2 protein in macrophages associated with cox2
2) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.07 Pain Relevance 0.60
Stimulation by endothelin-1 ranging from 10(-11) to 10(-9) M time and dose dependently increased the production of prostaglandin E2 and the expression of cyclooxygenase 2 protein without changing that of cyclooxygenase 1 protein, an effect which was inhibited by dexamethasone, nonsteroidal anti-inflammatory drugs and the selective endothelin ET(B) receptor antagonist, BQ788 (N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methyl-leucyl-D-L-me thoxycarbonyl-tryptophanyl-D-norleucine).
Positive_regulation (increased) of Gene_expression (expression) of cyclooxygenase 2 protein associated with inflammation, antagonist, cinod, cox2, dexamethasone and cox1
3) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.58 Pain Relevance 0.82
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Positive_regulation (lipopolysaccharide-induced) of Gene_expression (induction) of cyclooxygenase-2 in alveolar macrophages
4) Confidence 0.50 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.50 Pain Relevance 0.55
RESULTS: Angelicae Tenuissimae Radix suppressed prostaglandin E(2) synthesis and nitric oxide production by inhibiting the lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase messenger RNA in mouse BV2 microglial cells.
Positive_regulation (induced) of Gene_expression (expressions) of cyclooxygenase-2 in microglial cells
5) Confidence 0.50 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034447 Disease Relevance 0.24 Pain Relevance 0
SC suppressed production of nitric oxide and induction of iNOS and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
Positive_regulation (induction) of Gene_expression (production) of cyclooxygenase-2 in macrophages
6) Confidence 0.49 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18790036 Disease Relevance 0.20 Pain Relevance 0
PGH synthase-2 is undetectable in most cells but can be induced in fibroblasts, endothelial cells, ovarian follicles, and macrophages by various mitogens, cytokines, and tumor promoters.
Positive_regulation (induced) of Gene_expression (undetectable) of PGH synthase-2 in macrophages associated with cancer and cytokine
7) Confidence 0.48 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.32 Pain Relevance 0.31
The aqueous extract of Harpagophytum procumbens was shown to suppress PGE(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells.
Positive_regulation (enhancement) of Gene_expression (expressions) of cyclooxygenase-2 in L929
8) Confidence 0.47 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.24 Pain Relevance 0.30
The aqueous extract of Harpagophytum procumbens was shown to suppress PGE(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells.
Positive_regulation (inducible) of Gene_expression (expressions) of cyclooxygenase-2 in L929
9) Confidence 0.47 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.24 Pain Relevance 0.30
PGHS-2 is not expressed in stomach but is increased by inflammatory cytokines in cells such as macrophages.
Neg (not) Positive_regulation (increased) of Neg (not) Gene_expression (expressed) of PGHS-2 in macrophages associated with inflammation and cytokine
10) Confidence 0.45 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.33 Pain Relevance 0.51
Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

Background

Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclooxygenase-2 associated with adenoma, polyps and hyperplasia
11) Confidence 0.44 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2257954 Disease Relevance 2.32 Pain Relevance 0
The oral administration of the nonsteroidal anti-inflammatory drug sulindac inhibited the light-induced overexpression of cyclooxygenase-2 and oxidative stress-related genes in skin, and down-regulated smoke-induced genes involved in oxidative stress, removal of damaged proteins, inflammation, and immune response in lung.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclooxygenase-2 in skin associated with stress, inflammation and cinod
12) Confidence 0.42 Published 2004 Journal FASEB J. Section Abstract Doc Link 15289447 Disease Relevance 0.73 Pain Relevance 0.15
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclooxygenase-2 associated with cancer, familial adenomatous polyposis and cox2
13) Confidence 0.41 Published 1996 Journal Cancer Res. Section Title Doc Link 8653697 Disease Relevance 0.86 Pain Relevance 0.22
When mice were pretreated with LPS for 24 hr to induce cyclooxygenase-2 expression, the wild-type as well as EP(1)-, EP(2)-, or EP(4)-receptor-deficient mice showed a similar enhanced writhing response, whereas IP- and EP(3)-receptor-deficient mice had a significantly less enhanced number of writhings.
Positive_regulation (induce) of Gene_expression (expression) of cyclooxygenase-2
14) Confidence 0.36 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11389873 Disease Relevance 0.15 Pain Relevance 0.19
Among them, cyclooxygenase 2 (COX-2) overexpression has been shown in 60% to 80% of DCIS cases.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclooxygenase 2 associated with noninfiltrating intraductal carcinoma and cox2
15) Confidence 0.34 Published 2010 Journal Cancer Prev Res (Phila) Section Abstract Doc Link 20103725 Disease Relevance 1.01 Pain Relevance 0.15
In the present results, Armeniacae semen extract suppressed prostaglandin E2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase mRNA expression in BV2 cells.
Positive_regulation (inducible) of Gene_expression (expression) of cyclooxygenase-2 in semen
16) Confidence 0.33 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15744067 Disease Relevance 0.32 Pain Relevance 0.30
In the present results, Armeniacae semen extract suppressed prostaglandin E2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase mRNA expression in BV2 cells.
Positive_regulation (enhancement) of Gene_expression (expression) of cyclooxygenase-2 in semen
17) Confidence 0.33 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15744067 Disease Relevance 0.32 Pain Relevance 0.30
Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells.
Positive_regulation (Induction) of Gene_expression (expression) of cyclooxygenase-2 in liver associated with cancer and cox1
18) Confidence 0.33 Published 1997 Journal J. Biol. Chem. Section Title Doc Link 9013627 Disease Relevance 0.48 Pain Relevance 0.14
Increased expression of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin synthesis, has been associated with growth regulation and carcinogenesis in several systems.
Positive_regulation (Increased) of Gene_expression (expression) of cyclooxygenase-2
19) Confidence 0.33 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9013627 Disease Relevance 0.40 Pain Relevance 0.04
The present study investigated whether the endogenous pro-inflammatory cytokines [interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha)]-dependent expression of cyclooxygenase-2 (COX-2) mRNA within the spinal cord could be involved in the development of chronic inflammatory pain-like behaviors in mice.
Positive_regulation (-dependent) of Gene_expression (expression) of cyclooxygenase-2 in spinal cord associated with necrosis, inflammation, cancer, ipn, spinal cord and cytokine
20) Confidence 0.30 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262365 Disease Relevance 0.76 Pain Relevance 0.53

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