INT53083

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2011
Negated 6
Speculated 1
Reported most in Abstract
Documents 153
Total Number 154
Disease Relevance 90.04
Pain Relevance 50.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 14
spinal cord 5
microglial cells 5
skin 4
brain 3
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 354 100.00 Very High Very High Very High
cINOD 287 100.00 Very High Very High Very High
COX2 181 100.00 Very High Very High Very High
COX-2 inhibitor 111 100.00 Very High Very High Very High
Inflammatory mediators 55 100.00 Very High Very High Very High
Nerve growth factor 20 100.00 Very High Very High Very High
metalloproteinase 15 100.00 Very High Very High Very High
Analgesic 108 99.98 Very High Very High Very High
Hyperalgesia 29 99.96 Very High Very High Very High
Inflammation 724 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 905 100.00 Very High Very High Very High
Lewis Lung Carcinoma 14 99.98 Very High Very High Very High
Adenoma 141 99.96 Very High Very High Very High
Colon Cancer 106 99.96 Very High Very High Very High
Hyperalgesia 38 99.96 Very High Very High Very High
Cancer 768 99.92 Very High Very High Very High
Sepsis 25 99.92 Very High Very High Very High
Breast Cancer 41 99.86 Very High Very High Very High
Amyloid Plaque 9 99.78 Very High Very High Very High
Brain Injury 57 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of nimesulid caused apoptosis indices to be significantly higher along with cyclooxygenase-2 expression being significantly lower than in controls.
Gene_expression (expression) of cyclooxygenase-2 associated with apoptosis
1) Confidence 0.78 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 12725321 Disease Relevance 1.42 Pain Relevance 0.16
Using lipopolysaccharide-treated RAW 264.7 cells, down-regulation of cyclooxygenase-2 expression was found to be one of the cellular action mechanisms of anti-inflammation by Sedum kamtschaticum.
Gene_expression (expression) of cyclooxygenase-2 in RAW 264 associated with inflammation
2) Confidence 0.78 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15013209 Disease Relevance 0.55 Pain Relevance 0.29
The heterodimerization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expressing PGHS2 Y385F, but not in PGHS2-null mice.
Gene_expression (expressing) of PGHS2 in ductus arteriosus
3) Confidence 0.78 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.30 Pain Relevance 0.35
This system, using cells that express either PGHS-1 or PGHS-2, offers a convenient and reliable method to determine IC50 and IC80 values of the two PGHS isoforms, entirely independent of each other, in the same cell type.
Gene_expression (express) of PGHS-2
4) Confidence 0.77 Published 2001 Journal Inflamm. Res. Section Body Doc Link 11475335 Disease Relevance 0 Pain Relevance 0
Inhibitory effect of Angelicae Tenuissimae Radix on expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells.
Gene_expression (expressions) of cyclooxygenase-2 in microglial cells associated with cox2
5) Confidence 0.77 Published 2010 Journal Neurol. Res. Section Title Doc Link 20034447 Disease Relevance 0.09 Pain Relevance 0.32
PGHS-2 is not expressed in stomach but is increased by inflammatory cytokines in cells such as macrophages.
Neg (not) Gene_expression (expressed) of PGHS-2 in macrophages associated with inflammation and cytokine
6) Confidence 0.74 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.33 Pain Relevance 0.51
PGH synthase-2 is undetectable in most cells but can be induced in fibroblasts, endothelial cells, ovarian follicles, and macrophages by various mitogens, cytokines, and tumor promoters.
Gene_expression (undetectable) of PGH synthase-2 in macrophages associated with cancer and cytokine
7) Confidence 0.74 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.31 Pain Relevance 0.30
In contrast, PGHS-2 appears only to be expressed in inflamed tissue or following exposure to growth factors, lymphokines, or other mediators of inflammation.
Gene_expression (expressed) of PGHS-2 associated with inflammation
8) Confidence 0.74 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.41 Pain Relevance 0.45
Expression of PGHS-2 is inhibited by antiinflammatory glucocorticoids, lending further support to the hypothesis that this enzyme produces prostaglandins involved in inflammation.
Gene_expression (Expression) of PGHS-2 associated with inflammation
9) Confidence 0.74 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.49 Pain Relevance 0.55
PGH synthase-1 is present in platelets and endothelial cells whereas PGH synthase-2 has been detected in endothelial cells treated with cytokines and phorbol esters.
Gene_expression (detected) of PGH synthase-2 in endothelial cells associated with cytokine
10) Confidence 0.73 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.09 Pain Relevance 0.34
These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions.
Gene_expression (expressions) of cyclooxygenase-2 associated with inflammation and analgesic
11) Confidence 0.73 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.31 Pain Relevance 0.29
The aqueous extract of Harpagophytum procumbens was shown to suppress PGE(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells.
Gene_expression (expressions) of cyclooxygenase-2 in L929
12) Confidence 0.73 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.24 Pain Relevance 0.30
Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929.
Gene_expression (expressions) of cyclooxygenase-2 in fibroblast associated with cox2
13) Confidence 0.73 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14646256 Disease Relevance 0.28 Pain Relevance 0.34
Repeated applications of TPA resulted in stationary hyperplasia and downregulation of PGHS-2 expression and prostaglandin levels, suggesting that the epidermis had adapted to the TPA stimulus.
Gene_expression (expression) of PGHS-2 in epidermis associated with hyperplasia
14) Confidence 0.72 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 1.04 Pain Relevance 0.20
In papillomas and carcinomas, however, constitutive overexpression of PGHS-2 was found, with a large amount of prostaglandin E2 and prostaglandin F2 alpha.
Gene_expression (overexpression) of PGHS-2 associated with non-genital cutaneous warts and carcinoma
15) Confidence 0.72 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 1.02 Pain Relevance 0.18
Cyclooxygenase-2 protein in the exudates became detectable at 5-48 h after the lipopolysaccharide-pretreatment.
Gene_expression (detectable) of Cyclooxygenase-2 protein
16) Confidence 0.68 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9718266 Disease Relevance 0 Pain Relevance 0
Similarly, selective cyclooxygenase 2 inhibitors decrease adenomas in humans and rodents.
Gene_expression (decrease) of cyclooxygenase 2 associated with adenoma and cox2
17) Confidence 0.67 Published 2003 Journal Inflamm. Bowel Dis. Section Abstract Doc Link 12902846 Disease Relevance 1.28 Pain Relevance 0.14
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Gene_expression (induction) of cyclooxygenase-2 in alveolar macrophages
18) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.49 Pain Relevance 0.54
RESULTS: Angelicae Tenuissimae Radix suppressed prostaglandin E(2) synthesis and nitric oxide production by inhibiting the lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase messenger RNA in mouse BV2 microglial cells.
Gene_expression (expressions) of cyclooxygenase-2 in microglial cells
19) Confidence 0.66 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034447 Disease Relevance 0.24 Pain Relevance 0
The oral administration of the nonsteroidal anti-inflammatory drug sulindac inhibited the light-induced overexpression of cyclooxygenase-2 and oxidative stress-related genes in skin, and down-regulated smoke-induced genes involved in oxidative stress, removal of damaged proteins, inflammation, and immune response in lung.
Gene_expression (overexpression) of cyclooxygenase-2 in skin associated with stress, inflammation and cinod
20) Confidence 0.65 Published 2004 Journal FASEB J. Section Abstract Doc Link 15289447 Disease Relevance 0.73 Pain Relevance 0.15

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