INT531

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 376
Total Number 387
Disease Relevance 193.45
Pain Relevance 46.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
plasma 27
pituitary 21
blood 6
somatotroph 5
upper 5
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 798 100.00 Very High Very High Very High
Inflammation 422 100.00 Very High Very High Very High
Clonidine 223 100.00 Very High Very High Very High
Opioid 41 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
cytokine 248 99.98 Very High Very High Very High
cva 142 99.88 Very High Very High Very High
anesthesia 67 99.78 Very High Very High Very High
headache 449 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 4626 100.00 Very High Very High Very High
Cancer 4202 100.00 Very High Very High Very High
Pituitary Cancer 1701 100.00 Very High Very High Very High
INFLAMMATION 492 100.00 Very High Very High Very High
Adenoma 2041 99.98 Very High Very High Very High
Growth Problems 1892 99.98 Very High Very High Very High
Targeted Disruption 141 99.98 Very High Very High Very High
Growth Hormone-secreting Pituitary Adenoma 107 99.98 Very High Very High Very High
Anxiety Disorder 48 99.96 Very High Very High Very High
Diabetes Mellitus 1041 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine induced a greater total serum growth-hormone production in PD than in SND (p = 0.01).
Gene_expression (production) of growth-hormone associated with disease and clonidine
1) Confidence 0.75 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12242540 Disease Relevance 1.21 Pain Relevance 0.35
Serum levels of ghrelin, insulin, insulin-like growth factor 1, growth hormone (GH), triglycerides, free fatty acids, and glucose were measured.
Gene_expression (levels) of growth hormone
2) Confidence 0.75 Published 2010 Journal Cancer Section Body Doc Link 20186829 Disease Relevance 0.08 Pain Relevance 0
[A case report of adjacent tumor of sphenoid ridge meningioma and GH producing pituitary adenoma].
Gene_expression (producing) of GH in pituitary associated with meningioma, cancer and pituitary cancer
3) Confidence 0.73 Published 1991 Journal No Shinkei Geka Section Title Doc Link 1881528 Disease Relevance 1.46 Pain Relevance 0.09
Although GH producing pituitary adenoma may stimulate adjacent dura and arachnoid cells resulting in the formation of meningioma, the possibility of coincidental occurrence of the two tumors cannot be ignored.
Gene_expression (producing) of GH in pituitary associated with meningioma, cancer and pituitary cancer
4) Confidence 0.73 Published 1991 Journal No Shinkei Geka Section Abstract Doc Link 1881528 Disease Relevance 1.70 Pain Relevance 0.05
The form in which GH is supplied and administered entails taking an inconvenient hospital method into the daily family routine.
Gene_expression (supplied) of GH
5) Confidence 0.67 Published 1988 Journal Acta Paediatr Scand Suppl Section Abstract Doc Link 3057801 Disease Relevance 0 Pain Relevance 0.05
Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity.
Gene_expression (synthesis) of GH associated with enkephalin and opioid
6) Confidence 0.67 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9446709 Disease Relevance 0 Pain Relevance 0.20
Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.
Gene_expression (used) of GH
7) Confidence 0.67 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9446709 Disease Relevance 0 Pain Relevance 0.18
Silent mixed corticotroph and somatotroph adenomas are characterized by the following: no endocrine symptoms; presentation dominated by mass effect symptoms; macroadenoma presenting with acute pituitary hemorrhage; and production of both ACTH and GH.
Gene_expression (production) of GH in corticotroph associated with growth hormone-secreting pituitary adenoma and cva
8) Confidence 0.67 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11699555 Disease Relevance 0.74 Pain Relevance 0.24
Transnasal pituitary surgery in the three patients disclosed a pituitary adenoma producing ACTH and GH.
Gene_expression (producing) of GH in pituitary associated with pituitary cancer
9) Confidence 0.67 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11699555 Disease Relevance 0.77 Pain Relevance 0.29
[Growth hormone (GH) deficiency treatment in children: comparison between uses of pen versus bottles/syringes on GH administration].
Gene_expression (administration) of GH
10) Confidence 0.67 Published 2007 Journal Arq Bras Endocrinol Metabol Section Title Doc Link 18157384 Disease Relevance 0.07 Pain Relevance 0.07
Long-term studies are required to determine the efficacy and safety of GH treatment in older adults who are not GH deficient.
Neg (not) Gene_expression (deficient) of GH
11) Confidence 0.66 Published 2004 Journal Treat Endocrinol Section Abstract Doc Link 16026102 Disease Relevance 0.47 Pain Relevance 0.09
During the same period, subjects were also tested with GH-releasing hormone ([GHRH] 1 microgram/kg body weight in an intravenous [i.v.] bolus) and L-arginine, which releases GH from somatostatin inhibition (50 g in 50 mL normal saline over 30 minutes) to determine whether GH secretion in response to alternate secretagogues is preserved in alcoholics.
Gene_expression (tested) of GH in body associated with body weight and somatostatin
12) Confidence 0.66 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 8786727 Disease Relevance 0.26 Pain Relevance 0.31
Plasma GH levels were recorded over 2 hours in all tests.
Gene_expression (levels) of GH in Plasma
13) Confidence 0.66 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 8786727 Disease Relevance 0.29 Pain Relevance 0.42
Basal levels were similar but there was no rise in GH levels in the AF patients.
Gene_expression (levels) of GH
14) Confidence 0.66 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6398141 Disease Relevance 0.10 Pain Relevance 0.29
Dexamethasone administration to normal subjects did not alter GH levels in the first 2 h of the test.
Gene_expression (levels) of GH associated with dexamethasone
15) Confidence 0.66 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8284031 Disease Relevance 0.16 Pain Relevance 0.32
While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels.
Gene_expression (levels) of GH
16) Confidence 0.66 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0.05 Pain Relevance 0.74
While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels.
Gene_expression (level) of GH
17) Confidence 0.66 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0.06 Pain Relevance 0.71
It has recently been shown that brain cells targeted for early death by continued opiate use can be salvaged by injections of synthetic human growth hormone (GH).
Gene_expression (synthetic) of GH in brain associated with opiate and death
18) Confidence 0.65 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19897085 Disease Relevance 0.18 Pain Relevance 0.40
GH release in children after dexamethasone administration followed the pattern previously described for adults, i.e. there were no modifications of basal GH levels in the first 2 h, the GH peak appeared around the third hour, and the GH levels remained increased until the fourth hour after dexamethasone administration.
Gene_expression (levels) of GH associated with dexamethasone
19) Confidence 0.65 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1639956 Disease Relevance 0.13 Pain Relevance 0.31
The clinical usefulness of liquid human growth hormone (hGH) (Norditropin SimpleXx in the treatment of GH deficiency.
Gene_expression (usefulness) of hGH associated with pain
20) Confidence 0.65 Published 1999 Journal Horm. Res. Section Title Doc Link 10592454 Disease Relevance 0 Pain Relevance 0.10

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