INT5311

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 0.99
Pain Relevance 7.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
ARC 2
tail 2
kidney 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 71 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
opiate 2 99.68 Very High Very High Very High
Kinase C 23 99.18 Very High Very High Very High
tolerance 9 98.56 Very High Very High Very High
Enkephalin 12 98.16 Very High Very High Very High
Endogenous opioid 4 97.24 Very High Very High Very High
midbrain 1 93.04 High High
dopamine receptor 1 89.08 High High
Disease Link Frequency Relevance Heat
Eating Disorder 4 100.00 Very High Very High Very High
Aids-related Complex 2 98.72 Very High Very High Very High
Body Weight 3 96.08 Very High Very High Very High
Chronic Renal Failure 1 90.48 High High
Stress 3 80.96 Quite High
Neuroblastoma 2 65.36 Quite High
Coronary Heart Disease 1 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with other data, the present results support the conclusion that the aversive effect of opioid receptor blockade in the opiate non-dependent organism may be general to a wide range of species including primates.
Regulation (effect) of Negative_regulation (blockade) of opioid receptor associated with opiate and opioid receptor
1) Confidence 0.43 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2829268 Disease Relevance 0 Pain Relevance 0.57
The influence of naltrexone-induced opioid receptor blockade on the response of thyrotropin to two different acute stressors was studied in adult male rats.
Regulation (influence) of Negative_regulation (blockade) of opioid receptor associated with opioid receptor
2) Confidence 0.27 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2171723 Disease Relevance 0.16 Pain Relevance 0.27
Thus, the result of this study did not suggest that alteration in transcription of gene-encoding delta-opioid receptor was responsible for the down-regulation of delta-opioid receptor associated with the development of tolerance to DADLE.
Regulation (responsible) of Negative_regulation (down-regulation) of delta-opioid receptor associated with tolerance and opioid receptor
3) Confidence 0.27 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.64
Prior DOR-1 blockade did not alter the PC mediated, progressive loss of DOR-2 vagolytic responses.
Neg (not) Regulation (alter) of Negative_regulation (blockade) of DOR-1 associated with opioid receptor
4) Confidence 0.19 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18997098 Disease Relevance 0.06 Pain Relevance 0.92
Role for C-tail residues in delta opioid receptor downregulation.
Regulation (Role) of Negative_regulation (downregulation) of opioid receptor in tail associated with opioid receptor
5) Confidence 0.18 Published 2000 Journal DNA Cell Biol. Section Title Doc Link 10701775 Disease Relevance 0 Pain Relevance 0.39
Effect of agmatine on DAMGO-induced mu-opioid receptor down-regulation and internalization via activation of IRAS, a candidate for imidazoline I(1) receptor.
Regulation (Effect) of Negative_regulation (down-regulation) of opioid receptor associated with opioid receptor
6) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18845140 Disease Relevance 0 Pain Relevance 0.46
In the present study, the effects of agmatine activation on imidazoline I(1) receptor on the desensitization, down-regulation and internalization of micro opioid receptor were investigated.
Spec (investigated) Regulation (effects) of Negative_regulation (down-regulation) of micro opioid receptor associated with opioid receptor
7) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18845140 Disease Relevance 0 Pain Relevance 0.45
In both CHO-micro cells and CHO-micro/IRAS cells, agmatine (0.01-10 microM) did not affect the desensitization of micro opioid receptor induced by [d-Ala(2), N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) (10 microM) treatment for 30 min.
Neg (not) Regulation (affect) of Negative_regulation (desensitization) of micro opioid receptor associated with enkephalin and opioid receptor
8) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18845140 Disease Relevance 0 Pain Relevance 0.54
[Effect of opioid receptor blockade with naloxone on plasma renin activity and aldosterone levels in patients with kidney transplantation].
Regulation (Effect) of Negative_regulation (blockade) of opioid receptor in kidney associated with narcan and opioid receptor
9) Confidence 0.04 Published 1992 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 1300552 Disease Relevance 0.09 Pain Relevance 0.40
Two studies examined the effects of food restriction and deprivation on opioid mRNA levels in the arcuate nucleus (ARC) of the rat.
Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (deprivation) of opioid mRNA in ARC associated with aids-related complex, opioid and eating disorder
10) Confidence 0.03 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.62 Pain Relevance 0.37
Effects of opioid receptor blockade on luteinizing hormone (LH) pulses and interpulse LH concentrations in normal women during the early phase of the menstrual cycle.
Regulation (Effects) of Negative_regulation (blockade) of opioid receptor associated with opioid receptor
11) Confidence 0.01 Published 1992 Journal J. Endocrinol. Invest. Section Title Doc Link 1447490 Disease Relevance 0 Pain Relevance 0.22
However, chronic exposure to phorbol ester, which depletes the cells of diacylglycerol (DAG) and Ca2+-sensitive PKC isoforms, before DAMGO exposure, had no effect on opioid receptor down-regulation.
Neg (no) Regulation (effect) of Negative_regulation (down-regulation) of opioid receptor associated with kinase c and opioid receptor
12) Confidence 0.01 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.07 Pain Relevance 1.71
Effects of dopaminergic receptor stimulation and opioid receptor blockade on GH incretion: preliminary findings.
Regulation (Effects) of Negative_regulation (blockade) of opioid receptor associated with narcan and opioid receptor
13) Confidence 0.01 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Title Doc Link 6257257 Disease Relevance 0 Pain Relevance 0.28

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