INT53111

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1994
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.15
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DGCR14) molecular_function (DGCR14)
Anatomy Link Frequency
temporalis 2
neuronal 1
finger 1
skin 1
DGCR14 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 10 100.00 Very High Very High Very High
Endep 7 99.98 Very High Very High Very High
narcan 10 98.52 Very High Very High Very High
Pain 8 97.76 Very High Very High Very High
Serotonin 3 83.00 Quite High
headache 9 75.04 Quite High
noradrenaline 2 75.00 Quite High
medulla 5 65.20 Quite High
Central grey 5 62.80 Quite High
Raphe magnus 5 60.40 Quite High
Disease Link Frequency Relevance Heat
Depression 10 100.00 Very High Very High Very High
Headache 3 75.04 Quite High
Urological Neuroanatomy 5 62.80 Quite High
Myalgia 3 57.16 Quite High
Nociception 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that amitriptyline reduces ES2 and indicate that ES2 is modulated by serotonergic as well as noradrenergic neuronal pathways.
Negative_regulation (reduces) of ES2 in neuronal associated with endep
1) Confidence 0.51 Published 1996 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 8913195 Disease Relevance 0.22 Pain Relevance 0.78
After naloxone (0.4 mg or 4 mg, i.v.) there was a partial reversal of the index-induced ES2 depression, but this effect was not significant.
Spec (partial) Negative_regulation (depression) of ES2 associated with depression and narcan
2) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820620 Disease Relevance 0.23 Pain Relevance 0.19
Single peripheral electrical stimuli applied over nerve trunks or over the skin before the labial stimulus decreased ES2 duration.
Negative_regulation (decreased) of ES2 in skin
3) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820620 Disease Relevance 0.06 Pain Relevance 0.07
For stimulation at the index finger, temporalis ES2 inhibition progressively increased with intensity from 10 mA to 40 mA; it was maximal for an interstimulus interval between 50 and 140 ms.
Negative_regulation (inhibition) of ES2 in finger
4) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820620 Disease Relevance 0.14 Pain Relevance 0.11
Immersion of one hand in water heated at 47 degrees C produced a short-lasting ES2 reduction.
Negative_regulation (reduction) of ES2
5) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820620 Disease Relevance 0.24 Pain Relevance 0.23
Only injection of hypertonic saline into the right trapezius muscle could significantly reduce the ES2 offset time and decrease the degree of suppression of ES2 in the right temporalis and left trapezius muscles.
Negative_regulation (suppression) of ES2 in temporalis
6) Confidence 0.38 Published 2004 Journal Clin Neurophysiol Section Body Doc Link 15134708 Disease Relevance 0.11 Pain Relevance 0
Habituation or net inhibitory effects on inhibitory pre-motor neurones (i.e. disinhibition) are possible mechanisms for the observed reduction of the magnitude of ES2 suppression after repetitive stimulation.


Negative_regulation (suppression) of ES2
7) Confidence 0.37 Published 2002 Journal Clin Neurophysiol Section Body Doc Link 11856628 Disease Relevance 0 Pain Relevance 0
RESULTS: Consistent reduction of the magnitude of ES2 suppression in response to repetitive stimuli was observed below as well as above the pain detection threshold.
Negative_regulation (suppression) of ES2
8) Confidence 0.37 Published 2002 Journal Clin Neurophysiol Section Body Doc Link 11856628 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The observed reduction of the magnitude of ES2 suppression is not specifically related to nociceptive processing.
Negative_regulation (suppression) of ES2
9) Confidence 0.37 Published 2002 Journal Clin Neurophysiol Section Body Doc Link 11856628 Disease Relevance 0 Pain Relevance 0
For stimulation at the index finger, temporalis ES2 inhibition progressively increased with intensity from 10 mA to 40 mA; it was maximal for an interstimulus interval between 50 and 140 ms.
Negative_regulation (inhibition) of ES2 in temporalis
10) Confidence 0.13 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820620 Disease Relevance 0.14 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox