INT5312

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.73
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 8
kidney 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 6 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
Opioid 2 89.68 High High
anesthesia 7 83.84 Quite High
adenocard 29 73.76 Quite High
Calcium channel 25 69.08 Quite High
medulla 3 65.84 Quite High
COX-2 inhibitor 6 58.56 Quite High
tolerance 3 44.00 Quite Low
noradrenaline 2 32.44 Quite Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 2 95.48 Very High Very High Very High
Chronic Renal Failure 5 92.04 High High
Increased Venous Pressure Under Development 19 88.76 High High
Hypertension 35 72.56 Quite High
Cv Unclassified Under Development 2 68.64 Quite High
Stress 5 68.40 Quite High
Hypoxia 1 68.12 Quite High
Myocardial Infarction 46 50.00 Quite Low
Stroke 29 50.00 Quite Low
Renal Disease 9 24.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments were conducted to examine the effects of prostaglandin synthesis inhibitors on basal and isoproterenol-induced plasma renin concentration and renin gene expression in the late-gestation fetal lamb.
Spec (examine) Regulation (effects) of Gene_expression (expression) of renin gene in plasma
1) Confidence 0.41 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.11
For this reason, in healthy people, caffeine does not significantly affect renin production [80, 81].


Neg (not) Regulation (affect) of Gene_expression (production) of renin
2) Confidence 0.38 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.24 Pain Relevance 0.04
These experiments were conducted to examine the effects of prostaglandin synthesis inhibitors on basal and isoproterenol-induced plasma renin concentration and renin gene expression in the late-gestation fetal lamb.
Spec (examine) Regulation (effects) of Gene_expression (expression) of plasma renin in plasma
3) Confidence 0.30 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.11
[Effect of opioid receptor blockade with naloxone on plasma renin activity and aldosterone levels in patients with kidney transplantation].
Regulation ([Effect) of Gene_expression (activity) of renin in kidney associated with narcan and opioid receptor
4) Confidence 0.17 Published 1992 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 1300552 Disease Relevance 0.09 Pain Relevance 0.43
However, there were no significant differences between the groups in the changes in plasma renin activity, creatinine, and Cystatin-C levels.
Regulation (changes) of Gene_expression (levels) of plasma renin in plasma
5) Confidence 0.10 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782157 Disease Relevance 0.28 Pain Relevance 0.03
Our findings are consistent with the renin hypothesis, which suggests that patientsÂ’ blood pressure response to different antihypertensive drugs depends on their plasma renin levels.25
Regulation (consistent) of Gene_expression (hypothesis) of renin in plasma
6) Confidence 0.05 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2811239 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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