INT53150

Context Info Confidence 0.74 First Reported 1995 Last Reported 1995 Negated 1 Speculated 2 Reported most in Abstract Documents 3 Total Number 6 Disease Relevance 0.18 Pain Relevance 2.86

extracellular space (Scg2) extracellular region (Scg2) intracellular (Scg2)

Anatomy Link Frequency motor neurons 2 neck 1 motor nerve 1 head 1 Scg2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 44 100.00 tetrodotoxin 16 97.52 Sciatic nerve 4 97.52 Neuropeptide 8 95.96 Neurotransmitter 2 94.96 Spinal cord 6 94.88 substance P 8 85.12 Enkephalin 10 83.52

Disease Link Frequency Relevance Heat Ganglion Cysts 4 92.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression and content of calcitonin gene-related peptide (CGRP) and secretogranin II (SgII) in adult rat motor neurons were examined by in situ hybridization, Northern blot analysis, and immunocytochemistry.

Spec (examined) Gene_expression (expression) of SgII in motor neurons associated with calcitonin gene-related peptide

1) Confidence 0.74 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.40

No increase in SgII expression was observed.

Gene_expression (expression) of SgII

2) Confidence 0.74 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.79

The expression and content of calcitonin gene-related peptide (CGRP) and secretogranin II (SgII) in adult rat motor neurons were examined by in situ hybridization, Northern blot analysis, and immunocytochemistry.

Spec (examined) Gene_expression (expression) of secretogranin II in motor neurons associated with calcitonin gene-related peptide

3) Confidence 0.74 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.35

Normal motor nerve terminals did not contain detectable CGRP or SgII.

Neg (not) Gene_expression (detectable) of SgII in motor nerve associated with calcitonin gene-related peptide

4) Confidence 0.56 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7823160 Disease Relevance 0 Pain Relevance 0.60

In this study we examined the possible participation of a novel peptide, secretoneurin (a cleavage product of secretogranin II), in regulation of sympathetic outflow to head and neck by using a retrograde labelling-technique combined with immunohistochemistry.

Gene_expression (product) of secretogranin II in head

5) Confidence 0.24 Published 1995 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8527038 Disease Relevance 0.09 Pain Relevance 0.37

In this study we examined the possible participation of a novel peptide, secretoneurin (a cleavage product of secretogranin II), in regulation of sympathetic outflow to head and neck by using a retrograde labelling-technique combined with immunohistochemistry.

Gene_expression (product) of secretogranin II in neck

6) Confidence 0.08 Published 1995 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8527038 Disease Relevance 0.09 Pain Relevance 0.37

General Comments

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