INT5317

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Context Info
Confidence 0.46
First Reported 1982
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 8.27
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stromal cells 3
plasma 1
colon 1
brain 1
amniotic fluid 1
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 4 100.00 Very High Very High Very High
adenocard 3 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Inflammation 131 99.84 Very High Very High Very High
cINOD 35 99.52 Very High Very High Very High
cytokine 54 99.32 Very High Very High Very High
antagonist 1 99.20 Very High Very High Very High
Paracetamol 2 98.96 Very High Very High Very High
Sumatriptan 10 98.76 Very High Very High Very High
anesthesia 10 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 195 99.84 Very High Very High Very High
Cancer 58 99.84 Very High Very High Very High
Bone Cancer 7 99.80 Very High Very High Very High
Inflammatory Bowel Disease 11 99.46 Very High Very High Very High
Colon Cancer 7 99.20 Very High Very High Very High
Hypotension 8 98.56 Very High Very High Very High
Sprains And Strains 129 98.38 Very High Very High Very High
Hypertension 6 98.36 Very High Very High Very High
Chlamydia Infection 282 98.32 Very High Very High Very High
Squamous Cell Carcinoma 11 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since expression of both Cox-2 and PGE 2 is increased in the intestinal mucosa of patients with UC, as well as in CAC, Cox-2 induced PGE 2 may be a causal player in complex pathways linking chronic inflammation to the development of CAC [22-26].
Positive_regulation (induced) of PGE associated with inflammatory bowel disease, inflammation and cancer
1) Confidence 0.46 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.02 Pain Relevance 0.29
Excised segments of colon from CD mice were immersed in synthetic interstitial fluid (SIF) exposing the serosal surface during 5 min to different types of noxious stimuli; the increase in neuropeptide and PGE(2) release were analyzed (by EIA technique).
Spec (analyzed) Positive_regulation (increase) of PGE in colon associated with neuropeptide
2) Confidence 0.28 Published 2001 Journal Pain Section Abstract Doc Link 11514080 Disease Relevance 0.22 Pain Relevance 0.81
The test samples augmented the serum and mucosal PGE that correlated well with their respective abilities to regulate the expressions of the COX isoforms.
Positive_regulation (augmented) of PGE
3) Confidence 0.27 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.23 Pain Relevance 0.07
Analysis of PGE(2)-mediated activation of the DAF promoter employing 5'-deletion luciferase constructs suggests that regulation occurs at the transcriptional level via a cyclic AMP/protein kinase A-dependent pathway.
Positive_regulation (activation) of PGE
4) Confidence 0.27 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15520008 Disease Relevance 0.67 Pain Relevance 0.09
Mucosal levels of PGE(2) and 6-keto PGF(1a) increased after exposure to TC in all groups of mice.
Positive_regulation (increased) of PGE
5) Confidence 0.24 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.11
Significant elevation of prostaglandin E (PGE) and F (PGF) levels in amniotic fluid was noted with the progress of cervical dilatation.
Positive_regulation (elevation) of PGE in amniotic fluid
6) Confidence 0.23 Published 1983 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6873748 Disease Relevance 0 Pain Relevance 0.08
The supernatants from stromal cells accumulated IL-6, CXCL1, CCL20, and PGE in a concentration dependent manner for each LPS examined (Fig. 5A–D; ANOVA, P<0.05).
Positive_regulation (accumulated) of PGE in stromal cells
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.33 Pain Relevance 0.20
Treatment with BT, TF, and Omez increased the mucosal PGE by 157.7%, 163.1%, and 131.1%, respectively, compared to that in the ulcerated mice.


4.

Positive_regulation (increased) of PGE
8) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.17 Pain Relevance 0
PGE [42] and NO [43] are two potent mediators induced by inflammatory cytokines that stimulate their osteoclastogic activities.
Positive_regulation (induced) of PGE associated with inflammation and cytokine
9) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.95 Pain Relevance 0.83
Subsequent experiments used ultrapure LPS from E. coli and focused on the accumulation of IL-6, CXCL1, CCL20, and PGE.
Positive_regulation (accumulation) of PGE
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.26 Pain Relevance 0.11
Supernatants of the stromal cells treated with LPS accumulated IL-6, CXCL1, CCL20 and PGE over time (ANOVA, P<0.001) and in a treatment dependent manner (ANOVA, P<0.001) for each inflammatory mediator.
Positive_regulation (accumulated) of PGE in stromal cells associated with inflammation
11) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.25 Pain Relevance 0.13
On 1st postoperative day, Fc-Beta(2)-m significantly increased in PGE(1) group in both 3-hour and 6-hour hypotensive anesthesia, whereas it restored to normal on 2nd postoperative day.
Positive_regulation (increased) of PGE associated with anesthesia and hypotension
12) Confidence 0.11 Published 1990 Journal J Anesth Section Abstract Doc Link 15235974 Disease Relevance 0.62 Pain Relevance 0.58
CONCLUSION: The temporal profile of PGE(2) and TxB(2) in the immediate postoperative period is consistent with constitutive COX-1 initially, followed by an increase in PGE(2) resulting from expression of COX-2.
Positive_regulation (increase) of PGE
13) Confidence 0.11 Published 2002 Journal Clin. Pharmacol. Ther. Section Body Doc Link 12189364 Disease Relevance 0 Pain Relevance 0
Because NE upregulates NO synthases and NO induces cyclooxygenase (COX)-2-dependent PGE(2), we investigated whether NO mediates the production of this central fever mediator.
Positive_regulation (induces) of PGE associated with fever
14) Confidence 0.10 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17584955 Disease Relevance 0.27 Pain Relevance 0.09
Activation of alpha 2-adrenoceptors, opioid, A1-adenosine, and PGE receptors inhibited the stimulation-induced [3H]noradrenaline release in brain tissue in a concentration-dependent manner.
Positive_regulation (Activation) of PGE in brain associated with adenocard, noradrenaline and opioid
15) Confidence 0.06 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2171397 Disease Relevance 0 Pain Relevance 0.45
Yohimbine pretreatment did not affect the first T(c) rise, which continued unchanged for 6 h; the second rise, however, was absent, and PGE(2) levels did not increase.
Neg (not) Positive_regulation (increase) of PGE
16) Confidence 0.04 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17584956 Disease Relevance 0.13 Pain Relevance 0.17
Both PGE 2 and LTB 4 levels were increased in stage III and were correlated with each at this stage and in the subsequent stage.
Positive_regulation (increased) of PGE
17) Confidence 0.04 Published 2005 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15897851 Disease Relevance 0.07 Pain Relevance 0
Addition of LPS stimulated accumulation of PGE from epithelial (P<0.001; Fig. 5A) and stromal cells (P<0.001; Fig. 5B).
Positive_regulation (accumulation) of PGE in stromal cells
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.20 Pain Relevance 0.09
Preliminary experiments with bacteria in cluster 3 found no difference between the strains from diseased and unaffected animals Supernatants were collected after 24 h and analysed for steady-state PGE and IL-8 concentrations.
Spec (analysed) Positive_regulation (analysed) of PGE associated with sprains and strains
19) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820550 Disease Relevance 0.19 Pain Relevance 0
In osteogenic sarcoma samples, PGE and prostaglandin F2 alpha levels were higher than those of thromboxan B2, prostacyclin A2 and leucotriene B4.
Positive_regulation (higher) of PGE associated with bone cancer
20) Confidence 0.04 Published 1992 Journal Vopr Onkol Section Abstract Doc Link 1300802 Disease Relevance 0.95 Pain Relevance 0.07

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