INT53189

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 10.59
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VSX1) cellular_component (VSX1)
Anatomy Link Frequency
spinal cord 1
striatum 1
brain 1
corneal endothelial cells 1
tooth 1
VSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 28 100.00 Very High Very High Very High
Anterior cingulate cortex 2 99.90 Very High Very High Very High
cocaine 20 99.66 Very High Very High Very High
Dorsal horn 2 99.56 Very High Very High Very High
projection neuron 3 99.36 Very High Very High Very High
Spinal cord 20 98.00 Very High Very High Very High
Arthritis 2 97.88 Very High Very High Very High
Thalamus 2 97.44 Very High Very High Very High
Inflammation 72 95.24 Very High Very High Very High
Nucleus accumbens 24 94.24 High High
Disease Link Frequency Relevance Heat
Clinical Trials And Case Reports 24 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 100.00 Very High Very High Very High
Periodontitis 170 99.40 Very High Very High Very High
Crystal Associated Disease 2 98.12 Very High Very High Very High
Disease 112 97.44 Very High Very High Very High
Injury 10 97.32 Very High Very High Very High
Pressure And Volume Under Development 22 97.12 Very High Very High Very High
Rupture 4 96.68 Very High Very High Very High
INFLAMMATION 58 95.24 Very High Very High Very High
Systemic Lupus Erythematosus 3 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of short- and long-term cocaine exposure on the expression of the nuclear transcription factor genes, c-fos and zif/268, as well as the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in various regions of rat brain were evaluated by injecting i.p. saline or 10, 20, or 30 mg/kg cocaine HCl once daily for 1 or 10 days.
Gene_expression (expression) of PPD in brain associated with opioid and cocaine
1) Confidence 0.69 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.37
These data indicate that repeated, high dose cocaine administration induces an increased PPD but not PPE genomic response and that the expression of c-fos and zif/268 is dissociable from that of PPD.
Gene_expression (expression) of PPD associated with cocaine
2) Confidence 0.52 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.43
PPCD is an autosomal dominant genetically heterogenous entity with extremely variable expression.
Gene_expression (expression) of PPCD
3) Confidence 0.44 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.10 Pain Relevance 0
However, castrated male rats had significantly lower levels of PPD mRNA expression than intact male rats (P</=0.05).
Gene_expression (expression) of PPD mRNA
4) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.34 Pain Relevance 0.75
PPD mRNA expression was not altered on the contralateral side of the spinal cord in any group.
Gene_expression (expression) of PPD mRNA in spinal cord associated with spinal cord
5) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.33 Pain Relevance 0.76
Ovariectomized rats had significantly higher levels of PPD mRNA expression compared with intact male rats (P</=0.05).
Gene_expression (expression) of PPD mRNA
6) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.35 Pain Relevance 0.73
PPD mRNA expression ipsilateral to the injected paw was significantly higher in female rats in diestrus (P</=0.05) and proestrus (P</=0.01) compared with rats in estrus and intact male rats.
Gene_expression (expression) of PPD mRNA in paw
7) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.56 Pain Relevance 0.94
As with PPCD, the corneal endothelial cells in CHED express cytokeratin in contrast to normal corneal endothelium [143], but unlike PPCD the endothelial layer less often becomes multilayered [144].
Gene_expression (express) of PPCD in corneal endothelial cells
8) Confidence 0.39 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.09 Pain Relevance 0
The frequency of PPD positivity in AS patients (77.3%) was similar to that in gouty arthritis (70.4%) patients; and significantly higher than the frequency in SLE (21.4%) and RA (35.3%) patients (P values<0.001).
Gene_expression (positivity) of PPD associated with rheumatoid arthritis, crystal associated disease, systemic lupus erythematosus and arthritis
9) Confidence 0.38 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18682953 Disease Relevance 1.04 Pain Relevance 0.21
Considering the different therapies, SRP and AF provided better PPD reduction than no therapy.
Gene_expression (reduction) of PPD
10) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.19 Pain Relevance 0
For baseline PPD 4–5 mm they report PAL-V gains of 0.31 mm and PPD reduction of 1.1 mm after non-surgical as well as 0.21 mm and 1.6 mm after surgical therapy.
Gene_expression (reduction) of PPD
11) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.45 Pain Relevance 0
The diagnosis of aggressive periodontitis was associated with less favorable RAL-V gains, whereas it was not kept in the models to explain PPD reduction.
Gene_expression (reduction) of PPD associated with periodontitis
12) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.79 Pain Relevance 0
It is interesting to note that the diagnosis of aggressive periodontitis affected RAL-V gains but not PPD reduction.
Gene_expression (reduction) of PPD associated with periodontitis
13) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.72 Pain Relevance 0
However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.
Gene_expression (reductions) of PPD associated with clinical trials and case reports
14) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.18 Pain Relevance 0
However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.
Gene_expression (reduction) of PPD associated with clinical trials and case reports
15) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.25 Pain Relevance 0
However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.
Gene_expression (reduction) of PPD associated with clinical trials and case reports
16) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.25 Pain Relevance 0
However, calculation of a mean value, e.g., for PPD reduction, across a patient in fact levels out tooth-related characteristics.
Gene_expression (reduction) of PPD in tooth
17) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.34 Pain Relevance 0.06
However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.
Gene_expression (reductions) of PPD associated with clinical trials and case reports
18) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.18 Pain Relevance 0
Our PPD reductions and RAL-V gains achieved 6 months after therapy confirm data by a meta-analysis on nonsurgical vs surgical periodontal therapy that reports PPD reduction of 1.07 mm and vertical attachment (PAL-V) gains of 0.6 mm at sites with baseline PPD 4–6 mm 6 months after SRP.
Gene_expression (reductions) of PPD
19) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.13 Pain Relevance 0
Less favorable PPD reduction in premolars than in incisors was also recently reported by other authors [5].
Gene_expression (reduction) of PPD in incisors
20) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.33 Pain Relevance 0

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