INT53189

Context Info Confidence 0.69 First Reported 1994 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 32 Total Number 32 Disease Relevance 10.59 Pain Relevance 7.21

nucleus (VSX1) cellular_component (VSX1)

Anatomy Link Frequency spinal cord 1 striatum 1 brain 1 corneal endothelial cells 1 tooth 1 VSX1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 28 100.00 Anterior cingulate cortex 2 99.90 cocaine 20 99.66 Dorsal horn 2 99.56 projection neuron 3 99.36 Spinal cord 20 98.00 Arthritis 2 97.88 Thalamus 2 97.44 Inflammation 72 95.24 Nucleus accumbens 24 94.24

Disease Link Frequency Relevance Heat Clinical Trials And Case Reports 24 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 8 100.00 Periodontitis 170 99.40 Crystal Associated Disease 2 98.12 Disease 112 97.44 Injury 10 97.32 Pressure And Volume Under Development 22 97.12 Rupture 4 96.68 INFLAMMATION 58 95.24 Systemic Lupus Erythematosus 3 94.88

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of short- and long-term cocaine exposure on the expression of the nuclear transcription factor genes, c-fos and zif/268, as well as the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in various regions of rat brain were evaluated by injecting i.p. saline or 10, 20, or 30 mg/kg cocaine HCl once daily for 1 or 10 days.

Gene_expression (expression) of PPD in brain associated with opioid and cocaine

1) Confidence 0.69 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.37

These data indicate that repeated, high dose cocaine administration induces an increased PPD but not PPE genomic response and that the expression of c-fos and zif/268 is dissociable from that of PPD.

Gene_expression (expression) of PPD associated with cocaine

2) Confidence 0.52 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.43

PPCD is an autosomal dominant genetically heterogenous entity with extremely variable expression.

Gene_expression (expression) of PPCD

3) Confidence 0.44 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.10 Pain Relevance 0

However, castrated male rats had significantly lower levels of PPD mRNA expression than intact male rats (P</=0.05).

Gene_expression (expression) of PPD mRNA

4) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.34 Pain Relevance 0.75

PPD mRNA expression was not altered on the contralateral side of the spinal cord in any group.

Gene_expression (expression) of PPD mRNA in spinal cord associated with spinal cord

5) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.33 Pain Relevance 0.76

Ovariectomized rats had significantly higher levels of PPD mRNA expression compared with intact male rats (P</=0.05).

Gene_expression (expression) of PPD mRNA

6) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.35 Pain Relevance 0.73

PPD mRNA expression ipsilateral to the injected paw was significantly higher in female rats in diestrus (P</=0.05) and proestrus (P</=0.01) compared with rats in estrus and intact male rats.

Gene_expression (expression) of PPD mRNA in paw

7) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10692607 Disease Relevance 0.56 Pain Relevance 0.94

As with PPCD, the corneal endothelial cells in CHED express cytokeratin in contrast to normal corneal endothelium [143], but unlike PPCD the endothelial layer less often becomes multilayered [144].

Gene_expression (express) of PPCD in corneal endothelial cells

8) Confidence 0.39 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.09 Pain Relevance 0

The frequency of PPD positivity in AS patients (77.3%) was similar to that in gouty arthritis (70.4%) patients; and significantly higher than the frequency in SLE (21.4%) and RA (35.3%) patients (P values<0.001).

Gene_expression (positivity) of PPD associated with rheumatoid arthritis, crystal associated disease, systemic lupus erythematosus and arthritis

9) Confidence 0.38 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18682953 Disease Relevance 1.04 Pain Relevance 0.21

Considering the different therapies, SRP and AF provided better PPD reduction than no therapy.

Gene_expression (reduction) of PPD

10) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.19 Pain Relevance 0

For baseline PPD 4–5 mm they report PAL-V gains of 0.31 mm and PPD reduction of 1.1 mm after non-surgical as well as 0.21 mm and 1.6 mm after surgical therapy.

Gene_expression (reduction) of PPD

11) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.45 Pain Relevance 0

The diagnosis of aggressive periodontitis was associated with less favorable RAL-V gains, whereas it was not kept in the models to explain PPD reduction.

Gene_expression (reduction) of PPD associated with periodontitis

12) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.79 Pain Relevance 0

It is interesting to note that the diagnosis of aggressive periodontitis affected RAL-V gains but not PPD reduction.

Gene_expression (reduction) of PPD associated with periodontitis

13) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.72 Pain Relevance 0

However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.

Gene_expression (reductions) of PPD associated with clinical trials and case reports

14) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.18 Pain Relevance 0

However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.

Gene_expression (reduction) of PPD associated with clinical trials and case reports

15) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.25 Pain Relevance 0

However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.

Gene_expression (reduction) of PPD associated with clinical trials and case reports

16) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.25 Pain Relevance 0

However, calculation of a mean value, e.g., for PPD reduction, across a patient in fact levels out tooth-related characteristics.

Gene_expression (reduction) of PPD in tooth

17) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.34 Pain Relevance 0.06

However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.

Gene_expression (reductions) of PPD associated with clinical trials and case reports

18) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.18 Pain Relevance 0

Our PPD reductions and RAL-V gains achieved 6 months after therapy confirm data by a meta-analysis on nonsurgical vs surgical periodontal therapy that reports PPD reduction of 1.07 mm and vertical attachment (PAL-V) gains of 0.6 mm at sites with baseline PPD 4–6 mm 6 months after SRP.

Gene_expression (reductions) of PPD

19) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.13 Pain Relevance 0

Less favorable PPD reduction in premolars than in incisors was also recently reported by other authors [5].

Gene_expression (reduction) of PPD in incisors

20) Confidence 0.37 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.33 Pain Relevance 0

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