INT53196

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 44
Total Number 45
Disease Relevance 27.28
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 24
leukocyte 1
B cells 1
Gill 1
thymus 1
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 79 100.00 Very High Very High Very High
antagonist 85 99.60 Very High Very High Very High
depression 50 99.56 Very High Very High Very High
cytokine 307 99.52 Very High Very High Very High
Kinase C 25 98.64 Very High Very High Very High
Pain 52 98.36 Very High Very High Very High
Inflammation 328 96.60 Very High Very High Very High
Catecholamine 2 96.40 Very High Very High Very High
Arthritis 215 95.28 Very High Very High Very High
rheumatoid arthritis 281 94.96 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 772 100.00 Very High Very High Very High
Skin Cancer 49 100.00 Very High Very High Very High
Lymphopenia 46 100.00 Very High Very High Very High
Depression 50 99.56 Very High Very High Very High
Disease 409 99.52 Very High Very High Very High
Cancer 719 99.48 Very High Very High Very High
Targeted Disruption 75 99.08 Very High Very High Very High
Infection 342 98.44 Very High Very High Very High
Pain 47 98.36 Very High Very High Very High
Superinfection 20 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
L3T4 Binding (interact) of in T cells
1) Confidence 0.47 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.62 Pain Relevance 0.69
Antibodies were purchased from BD Pharmingen or eBioscience and included monoclonal antibodies recognizing mouse CD4 (RM4-5), CD8?
CD4 Binding (recognizing) of
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.05 Pain Relevance 0.04
While the overall number of participants with depression appeared lower among those with CD4 ?
CD4 Spec (appeared) Binding (those) of associated with depression
3) Confidence 0.37 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC519026 Disease Relevance 0.47 Pain Relevance 0.19
Pain was reported by over half of the participants, and by over three quarters of the participants with CD4 ?
CD4 Binding (participants) of associated with pain
4) Confidence 0.37 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC519026 Disease Relevance 0.60 Pain Relevance 0.49
During the induction of ACAID, there is a substantial increase that takes place in both CD4+ (p<0.01) and CD8+ T cells peaking on day 12 when comparing to respective splenic T cell populations in naïve mice.
CD4 Binding (peaking) of in T cells
5) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.29 Pain Relevance 0
We therefore analysed whether the frequencies of CD4+CD28null T cells in the circulation and in the synovial fluid were associated with the presence of ACPA in these compartments.
CD4 Binding (associated) of in T cells
6) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.64 Pain Relevance 0.09
Thus, overcoming cross-tolerance requires the cooperation of memory-like CD8+ and CD4+ T cells.
CD4 Binding (cross) of in T cells associated with tolerance
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.38 Pain Relevance 0.12
In general, MHC II-restricted CD4+ T cells recognize 9-13 amino acid peptides [16], [20].
CD4 Binding (recognize) of in T cells
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.11 Pain Relevance 0
Therefore, the percentages of CD4+ and CD8+ T cells in the BALF from B6 and Fc?
CD4 Binding (percentages) of in T cells
9) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.68 Pain Relevance 0.07
For instance, a CD4 clone recognizing a melanoma antigen could interaction in an HLA class I restricted fashion with tumor cells.
CD4 Binding (recognizing) of associated with cancer and skin cancer
10) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.94 Pain Relevance 0
For instance, a CD4 clone recognizing a melanoma antigen could interaction in an HLA class I restricted fashion with tumor cells.
CD4 Binding (interaction) of associated with cancer and skin cancer
11) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.94 Pain Relevance 0
Interactions between the HIV Env protein and CD4 lead to the exposure of the coreceptor-binding site, which includes the third variable loop (V3) of gp120 as well as the bridging sheet, a discontinuous epitope that is formed only after CD4 engagement.
CD4 Binding (engagement) of associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.28 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.49 Pain Relevance 0.12
Using triple transgenic mice, we are able to simulate the functional interaction between human CD4 and human MHC-II molecules.
CD4 Binding (interaction) of associated with targeted disruption
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.57 Pain Relevance 0.04
Secretion of GM-CSF by genetically-modified tumor cells stimulates cytokine release at the vaccine site to activate antigen-presenting cells, which prime CD4+ and CD8+ T cells to recognize circulating tumor-associated antigens, thereby inducing a tumor-specific cellular immune response.
CD4 Binding (recognize) of in T cells associated with cancer and cytokine
14) Confidence 0.26 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.90 Pain Relevance 0.17
PKC is normally activated upon binding of antigen to the T-cell receptor and its associated CD4 [58].
CD4 Binding (associated) of in T-cell associated with kinase c
15) Confidence 0.26 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.45 Pain Relevance 0.19
Notch signaling regulates CD4/CD8 T cell lineage commitment, whereas PS/?
CD4 Binding (commitment) of in T cell
16) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.85 Pain Relevance 0.13
Effective clearance of N. brasiliensis is associated with a CD4-driven TH2 cytokine response with IL-13 playing an essential role [1].
CD4 Binding (associated) of associated with cytokine
17) Confidence 0.24 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.28 Pain Relevance 0.14
Similarly, staining for CD3, CD4, CD8 or B220 was always negative in the CVOs of healthy mice (Table 1).


CD4 Binding (staining) of
18) Confidence 0.24 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.25 Pain Relevance 0
Although intriguing, T cell recognition of this same region of AQP4 is probably coincidental, since determinants recognized by CD4+ T cells are generally created through processing and association with MHC II molecules [16].
CD4 Binding (recognized) of in T cells
19) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0 Pain Relevance 0.04
As both prior chemotherapeutic treatment as well as CD4 count have been reported to influence patient response to DNX (Gill et al 1995), it may be important to determine patient response in the context of naïve, CD4 high (>100/?
CD4 Binding (count) of in Gill
20) Confidence 0.22 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.47 Pain Relevance 0

General Comments

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