INT53198

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.75
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 8
B cells 2
adrenal gland 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 27 99.74 Very High Very High Very High
Catecholamine 2 99.04 Very High Very High Very High
Inflammation 81 87.52 High High
agonist 20 81.44 Quite High
cytokine 93 79.36 Quite High
Central nervous system 21 78.84 Quite High
chemokine 29 60.44 Quite High
Inflammatory response 26 9.68 Low Low
imagery 27 5.00 Very Low Very Low Very Low
corticosteroid 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 67 100.00 Very High Very High Very High
Infection 164 99.96 Very High Very High Very High
Pain 30 99.74 Very High Very High Very High
Sprains And Strains 63 92.24 High High
Disease 49 87.76 High High
INFLAMMATION 108 87.52 High High
Cold Sores 367 75.16 Quite High
Cancer 204 75.04 Quite High
Influenza Virus Infection 82 72.32 Quite High
Paralysis 1 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation.
Positive_regulation (resulted) of Positive_regulation (activation) of L3T4 in adrenal gland associated with pain and catecholamine
1) Confidence 0.49 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.71 Pain Relevance 0.79
Surprisingly, in our model, no increase in CD4+ T cell activation was observed.
Neg (no) Positive_regulation (increase) of Positive_regulation (activation) of CD4 in T cell
2) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.96 Pain Relevance 0.04
Hence, immature BMDC induced higher frequencies of IL-17+CD4+ T cells when compared to their mature counterparts (Fig. 6E).
Positive_regulation (induced) of Positive_regulation (frequencies) of CD4 in T cells
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
We did not observe any differences in B cells (data not shown); however, we did observe significantly greater percentages of both activated CD4+ and CD8+ T cells in smoke-exposed pioglitazone-treated animals compared to controls (Figure 5E), despite no changes in the percentages of these cell types (data not shown).
Positive_regulation (percentages) of Positive_regulation (activated) of CD4 in B cells
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953496 Disease Relevance 0.66 Pain Relevance 0.25
These results suggest that CCL5 is required for optimal generation of Chlamydia-specific CD4+ T cells that proliferate after Ag recognition.


Positive_regulation (required) of Positive_regulation (generation) of CD4 in T cells associated with chlamydia infection
5) Confidence 0.26 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.71 Pain Relevance 0.06
The virus R3616 with the deletion of both ICP34.5 genes causes differences in the splenocyte subsets in comparison to the wild-type infection, inducing a stronger proliferation of CD4+ and CD8+T cells, as well as of the CD11c+ antigen presenting cells [334].
Positive_regulation (inducing) of Positive_regulation (proliferation) of CD4 in T cells associated with infection
6) Confidence 0.17 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.70 Pain Relevance 0.22

General Comments

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