INT5320

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 36
Disease Relevance 12.99
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTGFR) plasma membrane (PTGFR) cytoplasm (PTGFR)
signal transducer activity (PTGFR)
Anatomy Link Frequency
eyes 1
plasma 1
spinal cord 1
uterine 1
endometrium 1
PTGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.60 Very High Very High Very High
cytokine 9 98.58 Very High Very High Very High
Dismenorea 12 98.40 Very High Very High Very High
agonist 1 95.12 Very High Very High Very High
Inflammation 112 94.68 High High
allodynia 6 94.68 High High
pruritus 3 94.12 High High
antagonist 65 94.08 High High
Abeta 1 93.48 High High
acular 8 92.36 High High
Disease Link Frequency Relevance Heat
Aneuploidy 396 99.80 Very High Very High Very High
Hypotension 1 99.76 Very High Very High Very High
Endometriosis (extended) 30 99.72 Very High Very High Very High
Genomic Instability 162 99.58 Very High Very High Very High
Stress 72 99.44 Very High Very High Very High
Necrosis 3 99.40 Very High Very High Very High
Cancer 356 99.04 Very High Very High Very High
Malignant Neoplastic Disease 19 98.56 Very High Very High Very High
Dysmenorrhea 5 98.40 Very High Very High Very High
Bone Cancer 7 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin F2 alpha (PGF2 alpha) as its tromethamine salt was topically applied, and hypotensive and other ocular effects were studied, in glaucomatous human eyes.
Gene_expression (applied) of PGF2 in eyes associated with hypotension
1) Confidence 0.59 Published 1996 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 9063756 Disease Relevance 0.47 Pain Relevance 0
Levels of prostaglandin F2 alpha were significantly higher in maternal plasma during labour.
Gene_expression (Levels) of F2 alpha in plasma
2) Confidence 0.50 Published 1988 Journal J. Int. Med. Res. Section Abstract Doc Link 3169373 Disease Relevance 0.08 Pain Relevance 0.08
There was no significant change in the myometrial synthesis of PGI2, PGF2 alpha and PGE2, whereas the intracellular cGMP content was increased.
Gene_expression (synthesis) of PGF2
3) Confidence 0.45 Published 2001 Journal Gynecol. Endocrinol. Section Abstract Doc Link 11293922 Disease Relevance 0.13 Pain Relevance 0.14
The hypothesis proposed is that dietary (n-3)-PUFA in high amounts prolong gestation in human beings by interfering with uterine production of prostaglandins, possibly by inhibiting the production of dienoic prostaglandins, primarily PGF2 alpha and PGE2, which are mediators of uterine contractions and cervical ripening.
Gene_expression (production) of PGF2 in uterine associated with dismenorea
4) Confidence 0.45 Published 1986 Journal Lancet Section Abstract Doc Link 2874370 Disease Relevance 0.10 Pain Relevance 0.10
The differences in the levels of PGF2 alpha, TXA2, and LTB4 between normal and malignant tissue were not statistically significant.
Gene_expression (levels) of PGF2 alpha associated with malignant neoplastic disease
5) Confidence 0.40 Published 1993 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8228569 Disease Relevance 1.06 Pain Relevance 0.22
Production of prostaglandin (PG) E2 and PGF2 alpha was determined using specific radioimmunoassays.
Spec (determined) Gene_expression (Production) of PGF2
6) Confidence 0.36 Published 1990 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2251294 Disease Relevance 0.45 Pain Relevance 0.24
increases the G2/M population in HEK cells stably expressing the human FP prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
7) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
signaling in the cell cycle by utilizing a HEK cell line stably expressing the human FP prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
8) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.16 Pain Relevance 0
on cell cycle progression of HEK cells expressing the human FP prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
9) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.05 Pain Relevance 0
can also induce the formation of actin stress fibers in HEK cells stably expressing the human FP receptor, but not in the control cells stably transfected with the pCEP4 vector alone.
Gene_expression (expressing) of FP receptor associated with stress
10) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.59 Pain Relevance 0
treatment of HEK cells stably expressing the human FP prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
11) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.60 Pain Relevance 0
induces multipolar mitotic spindles and misaligned chromosomes in HEK cells stably expressing the human FP prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
12) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.25 Pain Relevance 0
induces abnormal cortical activity and generation of multiple nuclei in HEK cells stably expressing the human prostanoid receptor.
Gene_expression (expressing) of prostanoid receptor
13) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.28 Pain Relevance 0
treatment of HEK cells stably expressing the human FP prostanoid receptor increases expression of cyclin B1 (A) and increases Cdc2-mediated phosphorylation of histone H1 (B).
Gene_expression (expressing) of prostanoid receptor
14) Confidence 0.34 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Histograms of cell cycle distributions of HEK cells stably transfected with either the human FP prostanoid receptor (hFP-HEK) or with the empty vector (pCEP4-HEK) and treated with either vehicle (2% Na2CO3) or 1 µM PGF2?
Gene_expression (transfected) of prostanoid receptor
15) Confidence 0.29 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Lower panels: the relative percentages of multipolar spindles and misaligned chromosomes in mitotic cells stably transfected with empty vector (pCEP4-HEK) or the human FP prostanoid receptor (hFP-HEK) after treatment with 1 µM PGF2?
Gene_expression (transfected) of prostanoid receptor
16) Confidence 0.29 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.28 Pain Relevance 0
Upper panel: photomicrographs of HEK cells stably transfected with empty vector (pCEP4-HEK) or the human FP prostanoid receptor (hFP-HEK) following 1 h treatment with either vehicle (2% Na2CO3) or 1 µM PGF2?
Gene_expression (human) of prostanoid receptor in Upper
17) Confidence 0.29 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.52 Pain Relevance 0
can induce multipolar mitosis and increase aneuploidy in cells transfected with the human FP receptor.
Gene_expression (transfected) of FP receptor associated with aneuploidy
18) Confidence 0.29 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 1.40 Pain Relevance 0.23
Endotoxin and these cytokines all induced significant concentration-dependent increases in PGE2 and PGF2 alpha production.
Gene_expression (production) of PGF2 associated with cytokine
19) Confidence 0.28 Published 1990 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2251294 Disease Relevance 0.42 Pain Relevance 0.26
Recent evidence suggests that oxytocin is most important for the initial phase of labour, whereas increased synthesis of PGF2 alpha is essential for the progression of labour.
Gene_expression (synthesis) of PGF2 alpha
20) Confidence 0.26 Published 1984 Journal Br J Obstet Gynaecol Section Abstract Doc Link 6091729 Disease Relevance 0.07 Pain Relevance 0.07

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