INT53200

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.08
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
ductus arteriosus 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 21 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Inflammation 103 99.76 Very High Very High Very High
cINOD 17 98.16 Very High Very High Very High
Antinociceptive 5 92.84 High High
cytokine 20 92.60 High High
COX-2 inhibitor 1 79.76 Quite High
Analgesic 3 75.76 Quite High
withdrawal 3 65.40 Quite High
antinociception 2 56.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 8 99.92 Very High Very High Very High
INFLAMMATION 119 99.76 Very High Very High Very High
Alzheimer's Dementia 9 99.56 Very High Very High Very High
Nociception 3 98.72 Very High Very High Very High
Pain 2 98.64 Very High Very High Very High
Death 16 97.52 Very High Very High Very High
Cancer 26 93.04 High High
Atherosclerotic Plaque 3 89.04 High High
Disease 32 86.84 High High
Colorectal Cancer 1 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural modeling and biochemical assays showed the ability of PGHS1 and PGHS2 to heterodimerize and form prostaglandins.
PGHS2 Binding (heterodimerize) of
1) Confidence 0.48 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.33 Pain Relevance 0.38
OBJECTIVES: The objective of this study was to examine the nature of interaction between cyclooxygenase-2 inhibitor meloxicam and inducible nitric oxide synthase inhibitor aminoguanidine in formalin-induced nociception in mice and the possible therapeutic advantage.
cyclooxygenase-2 Spec (examine) Binding (interaction) of associated with nociception
2) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17703974 Disease Relevance 0.17 Pain Relevance 0
The heterodimerization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expressing PGHS2 Y385F, but not in PGHS2-null mice.
PGHS1-PGHS2 Binding (heterodimerization) of in ductus arteriosus
3) Confidence 0.37 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.32 Pain Relevance 0.37
The heterodimerization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expressing PGHS2 Y385F, but not in PGHS2-null mice.
PGHS1-PGHS2 Binding (heterodimerization) of in ductus arteriosus
4) Confidence 0.37 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.32 Pain Relevance 0.37
However, the discovery of the second isozyme, PGH synthase-2 (PGHS-2), and its association with inflammation has suggested that this latter enzyme may be the therapeutic target of NSAIDs functioning in their antiinflammatory capacities.
PGHS-2 Binding (association) of associated with inflammation and cinod
5) Confidence 0.34 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.38 Pain Relevance 0.47
However, the discovery of the second isozyme, PGH synthase-2 (PGHS-2), and its association with inflammation has suggested that this latter enzyme may be the therapeutic target of NSAIDs functioning in their antiinflammatory capacities.
PGH synthase-2 Binding (association) of associated with inflammation and cinod
6) Confidence 0.34 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.39 Pain Relevance 0.47
Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.
cyclooxygenase-2 Binding (Interaction) of associated with nociception and cox2
7) Confidence 0.34 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15178354 Disease Relevance 0.10 Pain Relevance 0.47
Renal cyclooxygenase-1 and cyclooxygenase-2 actively metabolize arachidonate to metabolism five primary prostanoids: prostaglandin E2, prostaglandin F2a, prostaglandin I2, thromboxane A2, and prostaglandin D2.
cyclooxygenase-2 Binding (metabolize) of
8) Confidence 0.13 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0 Pain Relevance 0.03
Jang and Surh showed that beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation through activation of NF-?
cyclooxygenase-2 Binding (associated) of associated with alzheimer's dementia and apoptosis
9) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2556656 Disease Relevance 1.69 Pain Relevance 0.16
Cyclooxygenase (COX) is an enzyme which catalyzes the first step in the formation of prostaglandins (PGs), the conversion of arachidonic acid to PGH2, followed by the metabolism of PGH2 to biologically active end-products, PGD2, PGE2, PGF?
PGH2 Binding (metabolism) of
10) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3004002 Disease Relevance 0.83 Pain Relevance 0.16
Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory drugs.
cyclooxygenase 2 Binding (interaction) of associated with inflammation, cinod and cox2
11) Confidence 0.03 Published 2003 Journal J Clin Psychiatry Section Title Doc Link 14658947 Disease Relevance 0.19 Pain Relevance 0.43
High levels of cyclooxygenase-1 and -2 (COX-1 and COX-2) inhibitory activity have been associated with certain Eucomis species.
cyclooxygenase-1 and -2 Binding (associated) of
12) Confidence 0.02 Published 2009 Journal Bull Environ Contam Toxicol Section Abstract Doc Link 19768359 Disease Relevance 0.36 Pain Relevance 0.23

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