INT53201

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 17.76
Pain Relevance 10.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
lung 2
kidney 2
anatomic regions 1
neuronal 1
nerve cells 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 33 100.00 Very High Very High Very High
antidepressant 120 99.98 Very High Very High Very High
Inflammatory response 156 99.84 Very High Very High Very High
tricyclic antidepressant 5 99.84 Very High Very High Very High
Morphine 516 99.64 Very High Very High Very High
fluoxetine 37 99.58 Very High Very High Very High
corticosteroid 58 99.36 Very High Very High Very High
Desipramine 8 99.36 Very High Very High Very High
Inflammation 435 99.34 Very High Very High Very High
Spinal cord 29 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 648 99.90 Very High Very High Very High
Stress 288 99.90 Very High Very High Very High
INFLAMMATION 619 99.84 Very High Very High Very High
Targeted Disruption 34 99.26 Very High Very High Very High
Poisoning 39 98.86 Very High Very High Very High
Rheumatoid Arthritis 13 98.84 Very High Very High Very High
Cancer 22 98.80 Very High Very High Very High
Multiple Sclerosis 100 98.08 Very High Very High Very High
Repression 25 98.08 Very High Very High Very High
Asthma 73 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected.
Negative_regulation (inhibition) of GR
1) Confidence 0.50 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.07 Pain Relevance 0.33
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Negative_regulation (decreased) of GR in anatomic regions
2) Confidence 0.41 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.97 Pain Relevance 0.19
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Negative_regulation (attenuated) of GR associated with desipramine and fluoxetine
3) Confidence 0.37 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
Moreover, it was found that JNK- and ERK-MAPK were oppositely involved in the regulation of the imipramine-induced inhibition of the GR functional activity.
Negative_regulation (inhibition) of GR
4) Confidence 0.37 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.05 Pain Relevance 0.31
These data indicate that the functional activity of GR evoked by low corticosterone concentration in LMCAT cells is efficiently inhibited by tricyclic antidepressants.
Negative_regulation (inhibited) of GR associated with tricyclic antidepressant
5) Confidence 0.37 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.06 Pain Relevance 0.34
Previously, we found that antidepressants inhibited glucocorticoid receptor (GR) function under the in vitro condition.
Negative_regulation (inhibited) of GR associated with antidepressant
6) Confidence 0.35 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16129923 Disease Relevance 0.52 Pain Relevance 0.42
In aged Brown Norway rat brain GR IR but not mineralocorticoid receptor (MR) IR is reduced in the hippocampal nerve cells.
Negative_regulation (reduced) of GR in nerve cells
7) Confidence 0.34 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825905 Disease Relevance 0.43 Pain Relevance 0.24
Both hippocampal cell proliferation and BDNF mRNA expression were down-regulated in GR-i mice, and these alterations were reversed by chronic agomelatine and fluoxetine treatments, whereas GR mRNA down-regulation was reversed only by agomelatine.
Negative_regulation (down-regulation) of GR associated with fluoxetine
8) Confidence 0.30 Published 2010 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19775499 Disease Relevance 0.36 Pain Relevance 0.74
OBJECTIVE: In patients with rheumatoid arthritis (RA) of longer duration, glucocorticoid receptor (GR) down-regulation has been reported without any change in cortisol levels.
Negative_regulation (regulation) of GR associated with rheumatoid arthritis
9) Confidence 0.29 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12175100 Disease Relevance 0.36 Pain Relevance 0.22
To this end, we used conditional GR knockout mice (GRlckCre), which specifically lack the GR in T cells [19].
Negative_regulation (lack) of GR in T cells associated with targeted disruption
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.76 Pain Relevance 0.09
Support for this concept came from of the analysis of GRdim mice that are defective in GR dimerization and DNA-binding [8], [9].
Negative_regulation (defective) of GR
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.65 Pain Relevance 0.27
In ADX rats supplemented with corticosterone, 5-HTP and fluoxetine treatment had the same effects on corticosteroid receptors compared to those observed in non supplemented ADX rats: 5-HTP decreased hippocampal MR and GR and hypothalamic GR while fluoxetine treatment increased hippocampal MR.
Negative_regulation (decreased) of GR associated with corticosteroid and fluoxetine
12) Confidence 0.25 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929085 Disease Relevance 0 Pain Relevance 0.96
The present study demonstrated that GR blockade can inhibit an increase in locomotor activity following morphine administration in C57BL/6J mice.
Negative_regulation (blockade) of GR associated with eae and morphine
13) Confidence 0.24 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0 Pain Relevance 0.86
Further studies revealed that blockade of the GR altered morphine-induced locomotor activity and development of physical dependence.


Negative_regulation (blockade) of GR associated with physical dependence, eae and morphine
14) Confidence 0.24 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.46 Pain Relevance 1.08
Moreover, acute morphine induction of two other genes, namely Sgk and Fzd2, also decreased toward the control level after blockade of GR receptor (20 mg/kg RU486; data not shown).
Negative_regulation (blockade) of GR associated with morphine
15) Confidence 0.24 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.12 Pain Relevance 1.01
We found ceruloplasmin (Cp) that was strongly induced by LPS (neuroprotection) and completely inhibited by the GR blockade (a neurotoxic condition).
Negative_regulation (blockade) of GR
16) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.32 Pain Relevance 0.04
Surprisingly we found that blocking endogenous GR signaling exacerbated the expression of a small and restricted set of inflammatory genes induced by LPS in the CNS.
Negative_regulation (blocking) of GR associated with inflammation and central nervous system
17) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.26 Pain Relevance 0.36
The extent of lipid peroxidation and the level of GSSG were also enhanced by the GalN intoxication whereas the activities of antioxidant enzymes SOD, CAT, GR and GST as well as the levels of total thiols and GSH were decreased in the kidney tissue homogenates.
Negative_regulation (decreased) of GR in kidney associated with poisoning
18) Confidence 0.19 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1868763 Disease Relevance 0.73 Pain Relevance 0
In the present study we found that GalN administration at a dose of 800 mg/kg body weight for three days caused enhanced oxidative insult in the kidney tissue as evidenced by the increased renal TBARS level and depletion in the activities of endogenous antioxidant enzymes such as SOD, CAT, GR and GST.
Negative_regulation (depletion) of GR in kidney associated with body weight
19) Confidence 0.19 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 1.04 Pain Relevance 0
There was reduction of GR activity in toxin control (142.18 ± 2.74 nmol/min/mg protein) compared to the normal control (293.38 ± 6.78 nmol/min/mg protein).
Negative_regulation (reduction) of GR
20) Confidence 0.19 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.08 Pain Relevance 0

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