INT53202

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.35
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
spinal cord dorsal horn 4
fibroblasts 3
nerve cells 2
T cells 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 100.00 Very High Very High Very High
Morphine 16 99.98 Very High Very High Very High
Desipramine 1 99.36 Very High Very High Very High
fluoxetine 1 98.84 Very High Very High Very High
Multiple sclerosis 34 98.40 Very High Very High Very High
Dorsal horn 2 97.80 Very High Very High Very High
Spinal cord 6 97.56 Very High Very High Very High
antidepressant 4 88.60 High High
intrathecal 3 86.60 High High
Inflammation 21 81.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 31 100.00 Very High Very High Very High
Aging 3 99.84 Very High Very High Very High
Sprains And Strains 4 99.12 Very High Very High Very High
Multiple Sclerosis 100 98.40 Very High Very High Very High
Cancer 10 95.60 Very High Very High Very High
Apoptosis 92 92.96 High High
Stress 2 91.32 High High
Nociception 1 76.88 Quite High
Disease 22 48.96 Quite Low
Retinoblastoma 1 32.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intensity of GR IR but not the number of nerve cells is altered, indicating a reduced activation of the GR in aging in this rat strain.
Negative_regulation (reduced) of Positive_regulation (activation) of GR in nerve cells associated with aging and sprains and strains
1) Confidence 0.46 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825905 Disease Relevance 0.52 Pain Relevance 0.21
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Negative_regulation (attenuated) of Positive_regulation (stimulated) of GR associated with desipramine and fluoxetine
2) Confidence 0.37 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
CpdA inhibited pro-inflammatory mediators in myelin-specific T cells and fibroblasts in a GR-dependent manner while gene activation was abolished.
Negative_regulation (inhibited) of Positive_regulation (mediators) of GR in fibroblasts associated with inflammatory mediators
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.87 Pain Relevance 0.19
The administration of the GR antisense oligodeoxynucleotide also prevented GR up-regulation within the spinal cord dorsal horn.
Negative_regulation (prevented) of Positive_regulation (up-regulation) of GR in spinal cord dorsal horn
4) Confidence 0.25 Published 2005 Journal Anesthesiology Section Body Doc Link 15791114 Disease Relevance 0 Pain Relevance 0
However, studies of NCoA6(TRBP) activity in cells deficient in DNA-PK indicate a marked reduction in NCoA6(TRBP)-mediated enhancement of GR activity, suggesting a role for DNA-PK in transcriptional activation [Ko and Chin, 2003].
Negative_regulation (reduction) of Positive_regulation (enhancement) of GR
5) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CpdA inhibited pro-inflammatory mediators in myelin-specific T cells and fibroblasts in a GR-dependent manner while gene activation was abolished.
Negative_regulation (inhibited) of in T cells Positive_regulation (mediators) of GR in fibroblasts associated with inflammatory mediators
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.87 Pain Relevance 0.19
Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma.
Negative_regulation (prevented) of Positive_regulation (upregulation) of GR in spinal cord dorsal horn associated with dorsal horn, morphine and spinal cord
7) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.41

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