INT53212

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (RAB27A) protein targeting (RAB27A) Golgi apparatus (RAB27A)
GTPase activity (RAB27A) lysosome (RAB27A)
Anatomy Link Frequency
seminal vesicle 1
RAB27A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 94.88 High High
aspirin 2 46.72 Quite Low
beta blocker 1 41.60 Quite Low
Neurotransmitter 2 21.36 Low Low
Inflammation 29 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 45 99.60 Very High Very High Very High
Diabetes Mellitus 8 99.48 Very High Very High Very High
Repression 2 98.70 Very High Very High Very High
Immunodeficiency 1 97.80 Very High Very High Very High
Piebaldism 3 96.96 Very High Very High Very High
INFLAMMATION 31 94.32 High High
Asthma 104 87.76 High High
Adenoma 2 84.80 Quite High
Diabetes Insipidus 2 81.44 Quite High
Insulin Resistance 2 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds I and II are now shown to inhibit homogeneous ram seminal vesicle prostaglandin H2 (PGH2) synthase by two kinetically distinct complexes.
Negative_regulation (inhibit) of ram in seminal vesicle
1) Confidence 0.57 Published 1995 Journal Biochemistry Section Abstract Doc Link 7827039 Disease Relevance 0.09 Pain Relevance 0.26
However, patients with GS type II-homozygous deficiency in Rab27a do not have diabetes mellitus.
Negative_regulation (deficiency) of Rab27a associated with diabetes mellitus and syndrome
2) Confidence 0.20 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.89 Pain Relevance 0
These conditions have been shown recently to be due to the expression of an inducible cAMP early repressor (ICER) [1], resulting in a repression of the transcription of the insulin gene, and associated with a diminished level of granuphilin, a Rab27a-dependent protein.
Negative_regulation (diminished) of Rab27a associated with repression
3) Confidence 0.20 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.95 Pain Relevance 0
Subjects with Rab27A deficiency develop Griscelli syndrome, which is characterized by immunodeficiency and partial albinism due to secretory defects in various cell types.
Negative_regulation (deficiency) of Rab27A associated with syndrome, piebaldism and immunodeficiency
4) Confidence 0.12 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.53 Pain Relevance 0

General Comments

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