INT53214

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Context Info
Confidence 0.05
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
brain 1
vesicle 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 29 100.00 Very High Very High Very High
Opioid 2 92.48 High High
Catecholamine 1 90.68 High High
Substantia nigra 3 82.04 Quite High
noradrenaline 2 74.32 Quite High
Serotonin 3 50.00 Quite Low
tolerance 6 22.24 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 5 99.84 Very High Very High Very High
Fatigue 24 97.08 Very High Very High Very High
Stress 18 95.24 Very High Very High Very High
Hypothermia 1 83.32 Quite High
Shock 7 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenotype of the calorie-independent IF-specific genes in the males contained the following GO term motifs: steroidal function (cholesterol metabolism); intracellular vesicle dynamics (intracellular transport, microtubule cytoskeleton organization, regulation of endocytosis); regulation of protein catabolism/degradation (proteolysis during cellular protein catabolism, ubiquitin-dependent protein catabolism, protein ubiquitination, ubiquitin cycle, small conjugating protein-specific protease activity, cysteine-type endopeptidase activity); cell signaling activity (signal transduction, amino acid phosphorylation, ATP binding, Ser/Thr kinase activity, Tyr kinase activity); transcriptional/translational regulation (RNA polymerase II activity, nuclear mRNA splicing, transcriptional coactivator activity, regulation of translation); stress management (response to stress).
Regulation (regulation) of Tyr kinase in vesicle associated with stress
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.19 Pain Relevance 0
Nybo et al. [8] however, found that brain uptake of Trp and Tyr as well as brain DA release were not affected by hyperthermia, failing therefore to support the classic "5-HT-central fatigue hypothesis" [37]; and also the involvement of brain DA function in thermoregulation during exercise in the heat.
Neg (not) Regulation (affected) of Tyr in brain associated with dopamine, fatigue and fever
2) Confidence 0.04 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.61 Pain Relevance 0.48
Opio-melanins precipitate in aqueous solutions below pH 5.0, and show apparent pKa values of 3.1, 3.6 and 4.4 for Tyr-Gly-melanin, Tyr-Gly-Gly-melanin and leuenk-melanin, respectively.
Regulation (values) of Tyr-Gly-melanin
3) Confidence 0.00 Published 1995 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7827110 Disease Relevance 0 Pain Relevance 0.17

General Comments

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