INT53217

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Context Info
Confidence 0.06
First Reported 1994
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.85
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
spinal cord 6
Neuronal 2
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 99.98 Very High Very High Very High
Versed 10 99.92 Very High Very High Very High
cINOD 20 99.78 Very High Very High Very High
Nerve growth factor 3 99.58 Very High Very High Very High
Spinal cord 15 99.00 Very High Very High Very High
ischemia 3 98.58 Very High Very High Very High
Morphine 27 98.40 Very High Very High Very High
Central nervous system 3 97.92 Very High Very High Very High
dexamethasone 1 94.88 High High
Hippocampus 4 94.64 High High
Disease Link Frequency Relevance Heat
Injury 8 99.98 Very High Very High Very High
INFLAMMATION 59 99.66 Very High Very High Very High
Cv Unclassified Under Development 3 98.58 Very High Very High Very High
Nociception 1 95.60 Very High Very High Very High
Disease 174 95.16 Very High Very High Very High
Neutrophil Disorders 9 93.80 High High
Adhesions 3 81.12 Quite High
Stress 9 80.16 Quite High
Death 24 79.76 Quite High
Drug Induced Neurotoxicity 15 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal cells respond to toxic insults including ischemia [73], zinc overload [72], and nerve growth factor deprivation [71] by inducing the expression and translocation of NADPH oxidase subunits.
Positive_regulation (inducing) of Gene_expression (expression) of NADPH in Neuronal associated with nerve growth factor and ischemia
1) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.38 Pain Relevance 0.15
-dependent activation of the NADPH oxidase, there is evidence suggesting vitamin E could potentially inhibit an A?
Positive_regulation (activation) of Gene_expression (oxidase) of NADPH
2) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.57 Pain Relevance 0.04
Subsequent studies have substantiated that the NADPH oxidase is essential for A?
Positive_regulation (essential) of Gene_expression (oxidase) of NADPH
3) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.45 Pain Relevance 0.05
The present study aimed to assess the role of anti-inflammatory drugs in injury-induced production of NADPH-d/NOS in CA1 pyramidal neurones.
Positive_regulation (induced) of Gene_expression (production) of NADPH-d associated with inflammation, injury and cinod
4) Confidence 0.01 Published 1994 Journal Neuroreport Section Abstract Doc Link 7827327 Disease Relevance 0.35 Pain Relevance 0.27
Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively.
Spec (determine) Positive_regulation (formalin-induced) of Gene_expression (expression) of NADPH-d associated with versed and morphine
5) Confidence 0.01 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740792 Disease Relevance 0.10 Pain Relevance 1.90
[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].
Positive_regulation (Increased) of Gene_expression (expression) of NADPH-d in spinal cord associated with pain, morphine and spinal cord
6) Confidence 0.00 Published 2000 Journal Sheng Li Xue Bao Section Title Doc Link 11956571 Disease Relevance 0 Pain Relevance 1.10
Morphine withdrawal increased the expression of Fos protein, NADPH-d positive, and Fos/NADPH-d double-labeled neurons, and they were observed in all the laminae of the rat spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of NADPH-d in spinal cord
7) Confidence 0.00 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11747755 Disease Relevance 0 Pain Relevance 0
Morphine withdrawal increased the expression of Fos protein, NADPH-d positive, and Fos/NADPH-d double-labeled neurons, and they were observed in all the laminae of the rat spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of NADPH-d in spinal cord
8) Confidence 0.00 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11747755 Disease Relevance 0 Pain Relevance 0

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