INT53232

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Context Info
Confidence 0.14
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1f5) extracellular region (Il1f5) molecular_function (Il1f5)
biological_process (Il1f5)
Anatomy Link Frequency
neurons 2
pituitary 2
Il1f5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 11 85.92 High High
Hippocampus 1 82.32 Quite High
Inflammation 13 75.20 Quite High
COX-2 inhibitor 19 39.36 Quite Low
anesthesia 1 25.00 Low Low
dopaminergic neurodegeneration 5 23.36 Low Low
Eae 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 99.16 Very High Very High Very High
Drug Induced Neurotoxicity 9 98.90 Very High Very High Very High
Urological Neuroanatomy 1 98.48 Very High Very High Very High
Parkinson's Disease 108 98.46 Very High Very High Very High
INFLAMMATION 27 85.52 High High
Death 13 84.56 Quite High
Injury 7 82.96 Quite High
Congenital Anomalies 1 59.36 Quite High
Disease 23 41.08 Quite Low
Targeted Disruption 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, [125I]interleukin-1 (IL-1)alpha binding was significantly increased in the pituitary at 2 h after the stress and tended to be higher than non-stressed levels at 6 h after the stress but was not statistically significant.
Positive_regulation (increased) of interleukin-1 Binding (binding) of in pituitary associated with stress
1) Confidence 0.14 Published 1994 Journal Brain Res. Section Abstract Doc Link 7827996 Disease Relevance 0.91 Pain Relevance 0.04
Damaged neurons can activate microglia, and as Wu et al. showed, the blockade of microglial activation by minocycline prevents MPTP-induced neurotoxicity with evidence of reduced microglial-derived cytotoxic mediators, such as the formation of mature interleukin-1?
Positive_regulation (mediators) of interleukin-1 Binding (formation) of in neurons associated with parkinson's disease and drug induced neurotoxicity
2) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.83 Pain Relevance 0.15

General Comments

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