INT5324

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 7.14
Pain Relevance 14.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
brain 2
hind limb 2
medial region 1
visceral 1
spinal 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 15 100.00 Very High Very High Very High
5HT 7 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Opioid 4 99.90 Very High Very High Very High
mu opioid receptor 4 99.80 Very High Very High Very High
fluoxetine 21 99.78 Very High Very High Very High
antagonist 52 99.68 Very High Very High Very High
IPN 2 99.60 Very High Very High Very High
Morphine 11 99.36 Very High Very High Very High
Spinal cord 9 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.60 Very High Very High Very High
Hyperalgesia 17 99.24 Very High Very High Very High
Convulsion 7 98.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

15 98.90 Very High Very High Very High
Pain 40 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.76 Very High Very High Very High
Somatoform Disorder 13 98.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 98.08 Very High Very High Very High
Depression 33 97.88 Very High Very High Very High
Hypoxia 4 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are discussed with respect to an interaction between N-methyl-D-aspartate and 5-HT2 receptors leading to the enhanced unit activity observed with noxious stimulation.
5-HT2 Binding (interaction) of
1) Confidence 0.47 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1301238 Disease Relevance 0 Pain Relevance 0.25
In spite of its high affinity for the 5-HT 2A receptor, methysergide only slightly elevated the pain threshold in the hyperalgesic hind limb.
5-HT 2A Binding (affinity) of in hind limb associated with hyperalgesia and pain threshold
2) Confidence 0.47 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16051396 Disease Relevance 1.18 Pain Relevance 1.06
Behavioral evidence for mu-opioid and 5-HT2A receptor interactions.
5-HT2A Binding (interactions) of associated with opioid
3) Confidence 0.47 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12909198 Disease Relevance 0 Pain Relevance 0.95
Electrophysiological studies have demonstrated a physiological interaction between 5-HT2A and mu-opioid receptors in the medial prefrontal cortex.
5-HT2A Binding (interaction) of in cortex associated with mu opioid receptor
4) Confidence 0.47 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12909198 Disease Relevance 0 Pain Relevance 0.39
Similar sized increases in 5-HT2A/2C binding (22%) were restricted to the medial striatum.
5-HT2A Binding (binding) of in striatum
5) Confidence 0.47 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630549 Disease Relevance 0 Pain Relevance 0.44
In contrast, the prominent increases in 5-HT2A/2C binding after severe 5-HT deprivation as restricted to the medial region of the striatum and suggest up-regulation of most probably 5-HT2C receptors in a region implicated in cognitive functions.
5-HT2A Spec (implicated) Binding (binding) of in medial region associated with cognitive disorder
6) Confidence 0.47 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630549 Disease Relevance 0.09 Pain Relevance 0.40
ECS treatment resulted in a similar time-dependent up-regulation of 5-HT2 receptor ligand binding; chronic, but not acute, ECS treatment significantly increased levels of [3H]ketanserin ligand binding, confirming previous reports.
5-HT2 Binding (binding) of associated with convulsion
7) Confidence 0.47 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.83 Pain Relevance 0.28
Both enantiomers were selective inhibitors of 5HT uptake in vitro and showed only weak affinity for 5HT-1, 5HT-1A and 5HT-2 receptors or for other receptors in rat brain.
5HT-2 Binding (affinity) of in brain associated with 5ht
8) Confidence 0.47 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3266670 Disease Relevance 0.19 Pain Relevance 1.00
The psychopharmacological effects of trazodone and dapiprazole are similar, whereas the binding inhibition to 5-HT2 receptors is different, which would indicate that the psychopharmacological effects do not primarily depend on these receptors.
5-HT2 Binding (binding) of
9) Confidence 0.47 Published 1988 Journal Drugs Exp Clin Res Section Abstract Doc Link 2839325 Disease Relevance 0 Pain Relevance 0.23
In the spinal cord 3H-5-HT bound to 5-HT1 receptors at a single high-affinity site with a Bmax value of 41.3 +/- 9.6 fmol/mg protein and a Kd value of 22.6 +/- 7.0 nmol/l. 3H-Spiperone bound to 5-HT2 receptors in the spinal cord with a Bmax value of 16.1 +/- 3.8 fmol/mg protein and a Kd value of 0.36 +/- 0.15 nmol/l.
5-HT2 Binding (bound) of in spinal cord associated with spinal cord
10) Confidence 0.47 Published 1989 Journal Pharmacology Section Abstract Doc Link 2587620 Disease Relevance 0 Pain Relevance 0.69
The binding of [3H]-ketanserin to sites other than 5-HT2 receptors can be examined and controlled for by autoradiographic techniques.
5-HT2 Binding (binding) of
11) Confidence 0.36 Published 1987 Journal J Clin Psychiatry Section Abstract Doc Link 3029045 Disease Relevance 0 Pain Relevance 0.29
The supraspinal mechanism by which ritanserin activates spinopetal pathways and its dependence on 5-HT2 receptors have not yet been established.
5-HT2 Binding (dependence) of associated with addiction
12) Confidence 0.36 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2501718 Disease Relevance 0.24 Pain Relevance 0.49
Interestingly, the highly selective 5-HT2A receptor antagonist MDL-100907 is also able to attenuate the effect of d-amphetamine on timing performance in this schedule, suggesting a functional interaction between D1 dopamine receptors and 5-HT2A receptors (Body et al. 2006b).
5-HT2A Binding (interaction) of in Body associated with dopamine receptor and antagonist
13) Confidence 0.36 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2761547 Disease Relevance 0 Pain Relevance 0.42
Many other TCAs also had high to intermediate affinity for both 5-HT2A and 5-HT2C receptors.
5-HT2A Binding (affinity) of
14) Confidence 0.36 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8876023 Disease Relevance 0 Pain Relevance 0.83
In morphine and placebo abstinent rats the binding of [3H]spiperone to 5-HT2 receptors in brain regions and spinal cord did not differ.
5-HT2 Binding (binding) of in brain associated with spinal cord and morphine
15) Confidence 0.36 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2591474 Disease Relevance 0.07 Pain Relevance 1.38
Results showed that none of the drugs changed the density or affinity of benzodiazepine binding sites, yet at the same dose all the drugs with the exception of fluoxetine decreased binding to 5-HT2A receptors in the same animals.
5-HT2A Binding (binding) of associated with fluoxetine
16) Confidence 0.36 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7553735 Disease Relevance 0 Pain Relevance 0.35
The binding characteristics of 5-HT2-receptors were unchanged by acute or chronic administration of clenbuterol.
5-HT2 Binding (binding) of
17) Confidence 0.36 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6225031 Disease Relevance 0.21 Pain Relevance 0.29
Furthermore, the 5-HT 2A receptor specific binding activity of 3H-ketanserin determined for the hyperalgesic hind limb did not differ from that of the normal hind limb.
5-HT 2A Binding (binding) of in hind limb associated with hyperalgesia
18) Confidence 0.36 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16051396 Disease Relevance 1.16 Pain Relevance 1.09
These findings suggest that spinal 5-HT3, opioid and GABA receptor systems interact to mediate acute chemo-inflammatory pain, and implicate the interaction of these systems with 5-HT2 receptor substrates in analgesia against acute thermal nociception.
5-HT2 Binding (interaction) of in spinal associated with nociception, ipn, gaba receptor, opioid and analgesia
19) Confidence 0.35 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1954980 Disease Relevance 0.53 Pain Relevance 1.60
This study examined whether the antinociception produced following the intrathecal (i.t.) administration of serotonin (5-hydroxytryptamine, 5-HT) and other 5-HT receptor agonists in a model of visceral pain that utilizes colorectal distension (CRD) as the noxious visceral stimulus is mediated through interaction with spinal 5-HT1, 5-HT2, or 5-HT3 receptor subtypes.
5-HT2 Binding (interaction) of in visceral associated with antinociception, visceral pain, agonist, serotonin and intrathecal
20) Confidence 0.35 Published 1991 Journal Brain Res. Section Abstract Doc Link 2018933 Disease Relevance 0 Pain Relevance 0.59

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