INT53240

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Context Info
Confidence 0.11
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.99
Pain Relevance 7.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
ileum 3
eosinophils 3
trigeminal ganglion 2
brain 2
epithelial cells 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 200 100.00 Very High Very High Very High
substance P 188 100.00 Very High Very High Very High
cytokine 69 100.00 Very High Very High Very High
burning pain 5 99.90 Very High Very High Very High
calcitonin gene related peptide 80 99.80 Very High Very High Very High
Calcitonin gene-related peptide 6 99.80 Very High Very High Very High
trigeminal ganglion 1 99.68 Very High Very High Very High
chemokine 47 99.48 Very High Very High Very High
antagonist 92 99.22 Very High Very High Very High
Migraine 4 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 13 100.00 Very High Very High Very High
Rhinitis 2 100.00 Very High Very High Very High
Asthma 2 100.00 Very High Very High Very High
Pain 11 99.90 Very High Very High Very High
Tooth Loss 13 99.80 Very High Very High Very High
Ganglion Cysts 7 99.68 Very High Very High Very High
INFLAMMATION 255 99.62 Very High Very High Very High
Esophageal Disease 110 98.14 Very High Very High Very High
Increased Venous Pressure Under Development 8 97.96 Very High Very High Very High
Inflammatory Bowel Disease 5 96.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, it has been described that SP is released during allergen challenge in patients with allergic asthma and rhinitis, stimulating mucous secretion and histamine release by mast cells, enhancing migration and cytotoxic activity of eosinophils, and stimulating T-cell proliferation [13-17].
Positive_regulation (enhancing) of in eosinophils Localization (released) of SP in mast cells associated with asthma, rhinitis and substance p
1) Confidence 0.11 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.06 Pain Relevance 0.45
Addition of thiorphan (100 nM), an inhibitor of neutral endopeptidase, enhanced the levels of SP-stimulated cytokine release.
Positive_regulation (enhanced) of Localization (release) of SP associated with cytokine and substance p
2) Confidence 0.09 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.32 Pain Relevance 0.93
Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP.
Positive_regulation (elicits) of Localization (release) of SP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, calcitonin gene-related peptide and substance p
3) Confidence 0.08 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7828188 Disease Relevance 0.79 Pain Relevance 1.45
In contrast, a selective IL-8 antibody, a PAF receptor antagonist, and an neurokinin-1 receptor antagonist (ie, SP antagonist) significantly reduced PBL migration, supporting a role of IL-8, PAF and SP as relevant chemokines.
Positive_regulation (supporting) of Localization (role) of SP associated with chemokine, antagonist and substance p
4) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.38 Pain Relevance 0.61
In the digestive tract most publications have focused on the role of vanilloid receptor in inflammation, with emphasis on stimulation of SP release,22-31 or on a role of endopeptidases in degradation of SP, with a resulting decrease in inflammation.32-34 In the ileum and colon, TRPV1 is thought to be a mediator of inflammation because, in experimental models of colitis induced by dextran sulphate sodium,35,36 or of ileitis induced by Clostridium difficile toxin A28 or anandamide,27 inflammation is attenuated in response to TRPV1 channel blockers35,36 or after genetic deletion of TRPV1.37
Positive_regulation (stimulation) of Localization (release) of SP in ileum associated with colitis, clostridium difficile infection, inflammation, ileitis and substance p
5) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.41 Pain Relevance 0.84
TRPV1 is now believed to function as a molecular integrator of noxious stimuli, including acids, heat, pollutants with negative electric charge and endogenous pro-inflammatory substances.16 Up-regulated TRPV1 expression has been demonstrated in disease states of the gastrointestinal tract such as inflammatory bowel disease,17 irritable bowel syndrome18 and, more recently, esophagitis.19,20 TRPV1 activation in primary afferent neurons evokes the sensation of burning pain and induces neurogenic inflammation by the release of substance P (SP) and calcitonin-gene-related peptide (CGRP).17,21

2.

Positive_regulation (induces) of Localization (release) of SP in bowel associated with calcitonin gene related peptide, esophageal disease, inflammation, neurogenic inflammation, disease, substance p and burning pain
6) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.15 Pain Relevance 0.85
We conclude that HCl-induced activation of TRPV1 receptors in esophageal epithelial cells results in neurally mediated release of SP and CGRP, and non-neurally mediated release of PAF from the epithelium (Fig. 9).

7.

Positive_regulation (activation) of Localization (release) of SP in epithelial cells associated with calcitonin gene related peptide and substance p
7) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.27 Pain Relevance 0.65
Activated eosinophils [6 x 10(6)/ml, suspended in Hanks' buffered salt solution (HBSS)] applied to cultured DRG neurons for 30 min increased basal SP release 2.4-fold compared with HBSS-exposed neurons (activated eosinophils 11.10 +/- 2.48% vs.
Positive_regulation (increased) of Localization (release) of SP in eosinophils associated with substance p
8) Confidence 0.03 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374740 Disease Relevance 0.25 Pain Relevance 0.40
In the presence of Sp4 in the brain, one could speculate that this effect may be magnified, because Sp4 binding to sites I and II is not affected by the loss of Sp binding to site III, and the resulting stimulated LTR may have high levels of both Sp and NF-?
Positive_regulation (stimulated) of Localization (levels) of Sp in brain
9) Confidence 0.03 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.58 Pain Relevance 0
The largest impact was found for the outcomes 'tooth loss', with a mean OHIP-Sp score = 13.5, and 'CAL ?
Positive_regulation (mean) of Localization (score) of OHIP-Sp in tooth associated with tooth loss
10) Confidence 0.03 Published 2006 Journal BMC Oral Health Section Body Doc Link PMC1534011 Disease Relevance 0.35 Pain Relevance 0.12
In the digestive tract most publications have focused on the role of vanilloid receptor in inflammation, with emphasis on stimulation of SP release,22-31 or on a role of endopeptidases in degradation of SP, with a resulting decrease in inflammation.32-34 In the ileum and colon, TRPV1 is thought to be a mediator of inflammation because, in experimental models of colitis induced by dextran sulphate sodium,35,36 or of ileitis induced by Clostridium difficile toxin A28 or anandamide,27 inflammation is attenuated in response to TRPV1 channel blockers35,36 or after genetic deletion of TRPV1.37
Positive_regulation (stimulation) of in colon Localization (release) of SP in ileum associated with colitis, clostridium difficile infection, inflammation, ileitis and substance p
11) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.41 Pain Relevance 0.84

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