INT53252

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.18
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kng1) extracellular region (Kng1)
Anatomy Link Frequency
plasma 3
hypothalamus 1
uterine 1
Kng1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 18 99.98 Very High Very High Very High
Inflammation 30 98.76 Very High Very High Very High
b2 receptor 3 96.80 Very High Very High Very High
Inflammatory response 1 96.00 Very High Very High Very High
Arthritis 24 94.36 High High
chemokine 2 81.36 Quite High
cytokine 6 80.88 Quite High
Dismenorea 4 80.80 Quite High
rheumatoid arthritis 40 69.32 Quite High
antagonist 5 59.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 98.76 Very High Very High Very High
Arthritis 25 94.36 High High
Targeted Disruption 12 92.12 High High
Pressure And Volume Under Development 11 90.28 High High
Experimental Arthritis 2 84.16 Quite High
Hereditary Angioedema 24 83.12 Quite High
Adhesions 5 82.12 Quite High
Syndrome 1 72.60 Quite High
Disease 12 69.84 Quite High
Rheumatoid Arthritis 40 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This fall was most likely due to increased bradykinin production from LMW kininogen, because uterine kallikrein activity was significantly elevated on days 21 and 22.
Gene_expression (production) of LMW kininogen in uterine associated with bradykinin
1) Confidence 0.67 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.18
The results of the study revealed that total kininogen levels in the plasma rose during pregnancy (days 15-22) to peak on day 22, the day of parturition.
Gene_expression (levels) of kininogen in plasma
2) Confidence 0.52 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.03
Total kininogen levels in the hypothalamus were undetectable during pregnancy; however, anterior pituitary kininogen levels increased markedly from days 15-22.
Gene_expression (levels) of kininogen in hypothalamus
3) Confidence 0.52 Published 1995 Journal Endocrinology Section Abstract Doc Link 7828557 Disease Relevance 0 Pain Relevance 0.06
T-kinin (Ile-Ser-bradykinin), the product of T-kininogen, has been found in rat plasma during systemic inflammation, but the effect of this kinin on airway inflammatory response is unknown.
Gene_expression (product) of T-kininogen in plasma associated with inflammatory response, inflammation and bradykinin
4) Confidence 0.22 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 8567553 Disease Relevance 0.19 Pain Relevance 0.26
B/N-Katholiek rats, which congenitally lack plasma kininogen and release no kinin, were also tested for hyperalgesic parameters.
Neg (lack) Gene_expression (lack) of kininogen in plasma
5) Confidence 0.15 Published 2003 Journal Inflamm. Res. Section Body Doc Link 12755382 Disease Relevance 0.14 Pain Relevance 0
This hormone also increases kininogen and kallikrein levels [10].
Gene_expression (levels) of kininogen
6) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.70 Pain Relevance 0.23
The activity of WAY-169916 is related to its ability to suppress inflammatory processes globally, as demonstrated by the decrease in serum acute-phase protein levels of haptoglobin, ?
Gene_expression (levels) of acute-phase protein associated with inflammation
7) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 1.15 Pain Relevance 0.51

General Comments

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