INT53256

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.33
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
thumb 2
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 24 95.72 Very High Very High Very High
opioid receptor 12 92.52 High High
Serotonin 36 78.48 Quite High
agonist 49 75.00 Quite High
opiate 2 64.88 Quite High
mu opioid receptor 21 50.00 Quite Low
Opioid 9 50.00 Quite Low
Potency 15 28.28 Quite Low
Morphine 115 25.84 Quite Low
narcan 17 10.92 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 95.24 Very High Very High Very High
Cancer 1 79.92 Quite High
Epilepsy 3 78.40 Quite High
Drug Dependence 4 5.00 Very Low Very Low Very Low
Mental Disorders 2 5.00 Very Low Very Low Very Low
Tics 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The delta receptor binding was reduced in epileptic focus obtained from patients with epilepsy secondary to cerebral lesion (-25%) and surrounding areas (-31%).
Negative_regulation (reduced) of receptor Binding (binding) of
1) Confidence 0.03 Published 2002 Journal Epilepsia Section Body Doc Link 12121327 Disease Relevance 0.24 Pain Relevance 0
This is presumed to be the limit of perceptible receptor interaction.
Negative_regulation (limit) of receptor Binding (interaction) of
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814854 Disease Relevance 0 Pain Relevance 0.04
As a rule of thumb, this is presumed to be the limit of perceptible receptor interaction.
Negative_regulation (limit) of receptor Binding (interaction) of in thumb
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814854 Disease Relevance 0 Pain Relevance 0
In the human receptor, the binding of L-162,313 was found to be unaffected by point mutations in transmembrane segments III and VII, which impaired the binding of biphenylimidazole antagonists.
Neg (unaffected) Negative_regulation (unaffected) of receptor Binding (binding) of associated with antagonist
4) Confidence 0.01 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7829475 Disease Relevance 0 Pain Relevance 0.36
PTX treatment abolishes interaction between the receptor and inhibitory Gi/o?
Negative_regulation (abolishes) of receptor Binding (interaction) of
5) Confidence 0.00 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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