INT5326

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Context Info
Confidence 0.55
First Reported 1987
Last Reported 2009
Negated 1
Speculated 3
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 4.56
Pain Relevance 7.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 5
blood 1
plasma 1
spinal cord 1
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 62 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
opioid receptor 13 99.18 Very High Very High Very High
Dorsal horn 1 98.68 Very High Very High Very High
methotrexate 5 98.44 Very High Very High Very High
dexamethasone 5 98.34 Very High Very High Very High
Spinal cord 1 96.44 Very High Very High Very High
Migraine 4 94.72 High High
cytokine 13 93.68 High High
Analgesic 4 92.64 High High
Disease Link Frequency Relevance Heat
Depression 1 99.98 Very High Very High Very High
Infection 35 99.40 Very High Very High Very High
Targeted Disruption 9 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.20 Very High Very High Very High
Viral Infection 2 98.82 Very High Very High Very High
Adhesions 8 98.76 Very High Very High Very High
Headache 4 94.72 High High
INFLAMMATION 8 89.08 High High
Arthritis 4 78.40 Quite High
Cv General 3 Under Development 5 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways.
Regulation (regulates) of interferon-gamma in T cells associated with morphine
1) Confidence 0.55 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12842891 Disease Relevance 0.34 Pain Relevance 0.82
The effects of subacute (15 mg/kg/12 h S.C. daily for one week) and chronic (10 mg/kg/12 h S.C. daily for one month) treatment with nefopam on the levels of interferon-gamma (IFN-gamma) and total immunoglobulins were examined in both normal and immunized mice.
Spec (examined) Regulation (effects) of IFN-gamma
2) Confidence 0.45 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.15 Pain Relevance 0.45
The effects of subacute (15 mg/kg/12 h S.C. daily for one week) and chronic (10 mg/kg/12 h S.C. daily for one month) treatment with nefopam on the levels of interferon-gamma (IFN-gamma) and total immunoglobulins were examined in both normal and immunized mice.
Spec (examined) Regulation (effects) of interferon-gamma
3) Confidence 0.45 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.15 Pain Relevance 0.45
Interferon-gamma receptor (IFN-gamma R) immunoreactivity was observed in the superficial dorsal horn and lateral spinal nucleus in rat and mouse spinal cord.
Regulation (immunoreactivity) of IFN-gamma in spinal cord associated with dorsal horn and spinal cord
4) Confidence 0.26 Published 1997 Journal Neuroreport Section Abstract Doc Link 9175135 Disease Relevance 0.26 Pain Relevance 0.24
In summary, our data indicate that morphine modulation of IFN-gamma promoter activity is mediated through two distinct cAMP-dependent pathways, the NF-kappaB signaling pathway and the ERK1/2, p38 MAPK, AP-1/NFAT pathway.
Regulation (modulation) of IFN-gamma in NFAT associated with morphine
5) Confidence 0.24 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.15 Pain Relevance 0.96
To explore the mechanism by which morphine promotes the incidence of HIV infection, we evaluated the regulatory role of morphine on the interferon-gamma (IFN-gamma) promoter in activated T cells from wild type and mu-opioid receptor knockout mice.
Regulation (role) of interferon-gamma in T cells associated with targeted disruption, acquired immune deficiency syndrome or hiv infection, opioid receptor, infection and morphine
6) Confidence 0.24 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.35 Pain Relevance 0.62
The inhibitory effects of morphine were not observed in T cells obtained from mu-opioid receptor knockout mice, suggesting that morphine modulation of IFN-gamma promoter activity is mediated through the mu-opioid receptor.
Regulation (modulation) of IFN-gamma in T cells associated with targeted disruption, opioid receptor and morphine
7) Confidence 0.24 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.17 Pain Relevance 1.05
Therefore, we sought to examine whether the ratio of IFN-gamma to IL-10 secreting cells is altered in patients with UA.
Spec (whether) Regulation (altered) of IFN-gamma
8) Confidence 0.22 Published 2005 Journal Int J Cardiovasc Intervent Section Body Doc Link 16243737 Disease Relevance 0.15 Pain Relevance 0
These data demonstrate that the CD4(+) T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-gamma, and IL-16 in mediating this pathogenic tissue response.
Regulation (role) of IFN-gamma in T cells associated with adhesions
9) Confidence 0.17 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18453619 Disease Relevance 0.82 Pain Relevance 0.10
The values of IFN-gamma were logarithmically transformed to get equal variances.
Regulation (values) of IFN-gamma
10) Confidence 0.12 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 0.32 Pain Relevance 0.11
The present study demonstrates the influence of endogenous IL-4 and IFN-gamma on blood pressure.
Regulation (influence) of IFN-gamma in blood
11) Confidence 0.12 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9920823 Disease Relevance 0.13 Pain Relevance 0.08
Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.
Regulation (effects) of IFN-gamma associated with methotrexate and dexamethasone
12) Confidence 0.10 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.55 Pain Relevance 0.58
These data suggest that the action of gamma-interferon complement synthesis is, at least partially, independent of PK-C activation.
Neg (independent) Regulation (independent) of gamma-interferon complement
13) Confidence 0.08 Published 1987 Journal J Clin Lab Immunol Section Abstract Doc Link 2449531 Disease Relevance 0 Pain Relevance 0.24
Data obtained both in vitro and in vivo with various experimental models shows that morphine increases susceptibility to bacterial and viral infections, the latter effect possibly being related to a depressive effect of opioids on gamma-interferon levels.
Regulation (effect) of gamma-interferon associated with depression, viral infection, opioid and morphine
14) Confidence 0.02 Published 1992 Journal Therapie Section Abstract Doc Link 1301643 Disease Relevance 0.66 Pain Relevance 0.93
Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels.
Regulation (trend) of gamma-IFN in plasma
15) Confidence 0.01 Published 1993 Journal Headache Section Abstract Doc Link 8294190 Disease Relevance 0.36 Pain Relevance 0.56

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