INT53263

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Context Info
Confidence 0.76
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 15.17
Pain Relevance 2.23

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Anatomy Mention Frequency
nasal 2
muscle 1
immune system 1
tsst-1 (Staphylococcus aureus)
Pain Term Frequency Confidence Heat
Inflammatory stimuli 1 99.78 Very High Very High Very High
Pain 14 99.28 Very High Very High Very High
aspirin 125 96.28 Very High Very High Very High
Inflammation 101 96.16 Very High Very High Very High
cytokine 50 95.12 Very High Very High Very High
chemokine 24 94.00 High High
headache 3 89.36 High High
rheumatoid arthritis 67 82.12 Quite High
antagonist 10 81.92 Quite High
alcohol 2 74.16 Quite High
Disease Term Frequency Confidence Heat
Staphylococcus Infection 43 100.00 Very High Very High Very High
Mrsa Infection 6 99.84 Very High Very High Very High
Sprains And Strains 25 99.82 Very High Very High Very High
INFLAMMATION 122 99.62 Very High Very High Very High
Chronic Sinusitis 126 99.60 Very High Very High Very High
Nasal Polyps 39 99.38 Very High Very High Very High
Myalgia 10 99.28 Very High Very High Very High
Urticaria 265 98.60 Very High Very High Very High
Injury 4 97.68 Very High Very High Very High
Recurrence 4 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Staphylococcus aureus with coagulase type IV was continuously isolated from nasal smears producing toxic shock syndrome toxin-1 (TSST-1).
Gene_expression (producing) of TSST-1 in nasal associated with staphylococcus infection
1) Confidence 0.76 Published 1994 Journal Eur. J. Pediatr. Section Abstract Doc Link 8033920 Disease Relevance 1.44 Pain Relevance 0.18
This isolated strain did not produce TSST-1.
Neg (not) Gene_expression (produce) of TSST-1 associated with sprains and strains
2) Confidence 0.75 Published 1994 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 7829911 Disease Relevance 1.20 Pain Relevance 0.11
According to the criteria, he was diagnosed as TSS, and TSST-1 was detected from his serum.
Gene_expression (detected) of TSST-1
3) Confidence 0.58 Published 1994 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 7829911 Disease Relevance 1.18 Pain Relevance 0.11
Also immunoglobulin G against TSST-1 was not detected from her sera both on admission and on discharge, which suggested that the patient belongs to the high risk group of TSS recurrence.
Neg (not) Gene_expression (detected) of TSST-1 associated with staphylococcus infection and recurrence
4) Confidence 0.55 Published 2001 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 11712366 Disease Relevance 1.67 Pain Relevance 0.08
MRSA isolated from her milk was coagulase type II producing toxic shock syndrome toxin-1 (TSST-1) and enterotoxin C.
Gene_expression (producing) of TSST-1 associated with staphylococcus infection and mrsa infection
5) Confidence 0.55 Published 2001 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 11712366 Disease Relevance 1.55 Pain Relevance 0.08
In that hospital, Methicillin-resistant Staphylococcus aureus(MRSA), with production of toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin(SE) type C(SEC), were isolated from inpatients, medical stuffs and hospital environments.
Gene_expression (production) of TSST-1 associated with staphylococcus infection and mrsa infection
6) Confidence 0.50 Published 2000 Journal Nippon Rinsho Section Abstract Doc Link 11225327 Disease Relevance 1.02 Pain Relevance 0.09
No direct correlation was observed between chronic rhinosinusitis, with or without nasal polyposis, and either agr groups or the presence of the most studied exotoxins genes (egc, sea, seb, pvl, exfoliatins or tsst-1).
Gene_expression (presence) of tsst-1 in nasal associated with chronic sinusitis and nasal polyps
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832699 Disease Relevance 0.90 Pain Relevance 0.03
The levels of total IgE and specific IgE directed against SEA, SEB, and TSST-1 were measured by the ImmunoCAP system (Pharmacia Diagnostics, Uppsala, Sweden) according to the manufacturer's instructions.


Gene_expression (levels) of TSST-1
8) Confidence 0.34 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.55 Pain Relevance 0.12
Specific IgE for SEA, SEB, and TSST-1 was detected in 14.6%, 13.1%, and 19.8% of the CU patients and in about 5% of the NC patients (p=0.041, p=0.049, and p=0.001, respectively).
Gene_expression (detected) of TSST-1 associated with urticaria
9) Confidence 0.34 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.46 Pain Relevance 0.05
With respect to IgE to individual staphylococcal toxins, IgE to TSST-1 was most prevalent in all three groups.
Gene_expression (prevalent) of TSST-1
10) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.38 Pain Relevance 0
The specific IgE to TSST-1 was the most prevalent in AICU patients, and statistical significance was noted in comparison with ATCU patients (p=0.047).
Gene_expression (prevalent) of TSST-1
11) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.33 Pain Relevance 0.03
Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC).
Gene_expression (antibodies) of TSST-1
12) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2580015 Disease Relevance 0.83 Pain Relevance 0.23
It produces exotoxins such as Staphylococcal enterotoxin B (SEB), SEA and toxic shock syndrome toxin-1 (TSST-1), which possess potent immune activity to affect immune system.
Gene_expression (produces) of TSST-1 in immune system associated with staphylococcus infection
13) Confidence 0.19 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 1.75 Pain Relevance 0.06
Microbiology revealed vaginal colonies of Staph. aureus (producing toxic shock syndrome toxin 1 [TSST-1]).
Gene_expression (producing) of TSST-1
14) Confidence 0.13 Published 2000 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 11190763 Disease Relevance 0.16 Pain Relevance 0
Two of the 103 CNS isolates from patients with muscle pain and none from the control subjects produced toxic shock syndrome toxin 1 (TSST-1), suggesting that pyrogenic toxins do not significantly contribute to the aetiology of chronic muscle pain.
Gene_expression (produced) of TSST-1 in muscle associated with staphylococcus infection, pain and myalgia
15) Confidence 0.08 Published 1998 Journal J. Med. Microbiol. Section Abstract Doc Link 9839561 Disease Relevance 0.77 Pain Relevance 0.58
Generation of TSST-1-specific ??
Gene_expression (Generation) of TSST-1-specific
16) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.17 Pain Relevance 0.03
Most of the pro-inflammatory stimuli including lipopolysaccharide, Concanavalin A, TSST-1, and TNF-?
Gene_expression (lipopolysaccharide) of TSST-1 associated with inflammatory stimuli
17) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.81 Pain Relevance 0.45

General Comments

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