INT5328

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 191
Total Number 195
Disease Relevance 133.43
Pain Relevance 21.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 74
regulatory T cells 10
lymphocyte 9
blood 4
natural killer cells 4
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 758 100.00 Very High Very High Very High
cytokine 1376 99.98 Very High Very High Very High
Morphine 3 99.82 Very High Very High Very High
addiction 239 99.70 Very High Very High Very High
5HT 23 99.62 Very High Very High Very High
Inflammation 1490 99.58 Very High Very High Very High
spinal inflammation 446 99.32 Very High Very High Very High
antagonist 393 99.30 Very High Very High Very High
Arthritis 552 98.84 Very High Very High Very High
Neuritis 20 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 992 100.00 Very High Very High Very High
Malaria 213 100.00 Very High Very High Very High
Influenza Virus Infection 166 100.00 Very High Very High Very High
Hypergammaglobulinemia 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6366 99.98 Very High Very High Very High
Cold Sores 698 99.94 Very High Very High Very High
Infection 2153 99.84 Very High Very High Very High
Disease 1465 99.80 Very High Very High Very High
Disease Progression 122 99.80 Very High Very High Very High
Anaerobic Bacterial Infections 39 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional CD4 CD25high regulatory cells are increased in patients with established pSS, through a reactive feedback, despite ongoing autoimmunity.
Positive_regulation (ncreased ) of CD4 associated with autoimmune disease
1) Confidence 0.69 Published 2005 Journal J. Autoimmun. Section Abstract Doc Link 15848046 Disease Relevance 0.37 Pain Relevance 0.06
The following laboratory abnormalities are seen with some frequency, although none are seen in all patients: lymphocytosis, atypical lymphocytosis, monocytosis, elevation of hepatocellular enzymes, low levels of antinuclear antibodies, varying levels of antithyroid antibodies, partial hypergammaglobulinemia, elevated CD4:CD8 ratio, decreased cytolytic activity of natural killer cells, and low levels of immune complexes.
Positive_regulation (elevation) of CD4 in natural killer cells associated with hypergammaglobulinemia, congenital anomalies and lymphocytosis
2) Confidence 0.69 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2691680 Disease Relevance 1.38 Pain Relevance 0.07
Examination of bronchoalveolar lavage fluid showed an elevated CD4/CD8 ratio.
Positive_regulation (elevated) of CD4
3) Confidence 0.67 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17651894 Disease Relevance 0.53 Pain Relevance 0.12
Immunologic abnormalities included antiphospholipid antibodies (32%), antithyroid antibodies (53%), antinuclear antibodies (28%), antiovarian antibodies (2%), increased natural killer cells (40%), increased immunoglobulin (Ig)M level (28%), and increased CD4/CD8 T-cell ratio (15%).
Positive_regulation (increased) of CD4 in T-cell associated with congenital anomalies
4) Confidence 0.67 Published 2000 Journal Fertil. Steril. Section Abstract Doc Link 10689009 Disease Relevance 0.65 Pain Relevance 0.05
Bronchoalveolar lavage (BAL) showed an increase in total cell count and an elevated CD4/CD8 ratio compatible with sarcoidosis, and absence of neoplastic cells or infectious agents.
Positive_regulation (elevated) of CD4 associated with sarcoidosis
5) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2924355 Disease Relevance 1.14 Pain Relevance 0.07
Small and transient increases in CD4 cell counts were detected during the first 4 weeks of treatment.
Positive_regulation (increases) of CD4
6) Confidence 0.67 Published 1995 Journal J. Infect. Dis. Section Abstract Doc Link 7751691 Disease Relevance 0.64 Pain Relevance 0.19
All measures showed changes in the desired direction (i.e. decrease in weight, chest, waist and hip sizes; and increase in CD4 count, fitness, flexibility, strength and perceived well-being).
Positive_regulation (increase) of CD4 in hip
7) Confidence 0.66 Published 2010 Journal The Open AIDS Journal Section Body Doc Link PMC2944991 Disease Relevance 0.26 Pain Relevance 0
This occurs clinically as a worsening of symptoms of inflammation or infection due to increases in CD4 count.
Positive_regulation (increases) of CD4 associated with inflammation and infection
8) Confidence 0.63 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.25 Pain Relevance 0.14
In those patients in whom ARV treatment has resulted in significant increases in CD4 count above 200/mm3, most OI prophylaxis can be safely discontinued in the majority of patients.
Positive_regulation (increases) of CD4 associated with opportunistic infections
9) Confidence 0.63 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 1.67 Pain Relevance 0
Most patients in other series also had advanced immune suppression at the initiation of HAART (CD4 cell count 30/mm3 or less) and a CD4 cell count increase in response to HAART at the time of IRIS diagnosis [4,11-13].
Positive_regulation (increase) of CD4 associated with immune reconstitution inflammatory syndrome
10) Confidence 0.57 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.74 Pain Relevance 0.09
This study on BAL fluid has also shown that the CD4/CD8 ratio is significantly increased in patients with bronchiectasis (Table 4).
Positive_regulation (increased) of CD4 associated with bronchiectasis
11) Confidence 0.52 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 1.58 Pain Relevance 0.41
As an earlier published study showed evidence of increases in CD4 cell counts due to this drug, we conducted a randomized, placebo-controlled, 8-week trial of oral cimetidine (400 mg p.o. t.i.d.) in a study involving 182 patients infected with human immunodeficiency virus (HIV).
Positive_regulation (increases) of CD4 associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.50 Published 1996 Journal Clin. Infect. Dis. Section Abstract Doc Link 8922801 Disease Relevance 0.45 Pain Relevance 0.09
The procedure for the CD4 count assay was as follows
Positive_regulation (procedure) of CD4
13) Confidence 0.50 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2918360 Disease Relevance 0.50 Pain Relevance 0
In contrast, the pool of CD4 CD25high was significantly increased in patients with pSS (8.5% vs 4.1% in controls, P=0.04).
Positive_regulation (increased) of CD4
14) Confidence 0.50 Published 2005 Journal J. Autoimmun. Section Abstract Doc Link 15848046 Disease Relevance 0.50 Pain Relevance 0.08
First, clearly it requires CD4 quantitation, which although is presently more available in our region of Tanzania, is also technically demanding and expensive.
Positive_regulation (requires) of CD4
15) Confidence 0.50 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1876460 Disease Relevance 0.61 Pain Relevance 0
Knowledge of the function of CD4 T cells in immune reconstitution was derived from large clinical studies demonstrating that primary and secondary prophylaxis against infectious agents, such as Pneumocystis jirovecii (Pneumocystis carinii), Mycobacterium avium complex, cytomegalovirus, and other pathogens, can be discontinued safely once CD4 T cell counts have increased beyond pathogen-specific threshold levels (usually >200 CD4 T cells/mm3) for 3-6 months.
Positive_regulation (increased) of CD4 in T cells associated with pneumocystis carinii infection and cytomegalovirus infection
16) Confidence 0.50 Published 2004 Journal Clin. Infect. Dis. Section Abstract Doc Link 15095223 Disease Relevance 1.04 Pain Relevance 0.10
Further studies examining the activation status of specific cellular subsets such as CD4+Th17 cells, which are elevated in the circulation of RA patients [34], [35], may be indicative of disease stage and activity.
Positive_regulation (elevated) of CD4 in Th17 cells associated with rheumatoid arthritis and disease
17) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.43 Pain Relevance 0.30
Possibly this is caused by the cellular reaction to rapid internalization of CD4, which is induced by antibody binding but not by DARPin binding [8], [23].
Neg (not) Positive_regulation (induced) of CD4
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.34 Pain Relevance 0
However, DS17 and DS17(N283T) displayed a mixed phenotype since they had intermediate fusogenicity with low CD4 dependence but a lack of increased avidity for CD4 (as indicated by the sensitivity to inhibition by the anti-CD4 mAb).


Positive_regulation (increased) of CD4 associated with addiction
19) Confidence 0.49 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0 Pain Relevance 0.10
The transient increase in CD4/CD8 ratio was likely due to the TCM intake.
Positive_regulation (increase) of CD4
20) Confidence 0.49 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437735 Disease Relevance 0.47 Pain Relevance 0.12

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