INT53282

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Context Info
Confidence 0.15
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.60
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp2b2) cell morphogenesis (Atp2b2) endoplasmic reticulum (Atp2b2)
plasma membrane (Atp2b2) locomotion (Atp2b2) cilium (Atp2b2)
Anatomy Link Frequency
plasma 1
reticulum 1
Atp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 18 98.28 Very High Very High Very High
isoflurane 3 97.84 Very High Very High Very High
anesthesia 6 74.08 Quite High
ischemia 96 68.16 Quite High
ASIC 12 66.72 Quite High
qutenza 48 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 30 5.00 Very Low Very Low Very Low
substance P 18 5.00 Very Low Very Low Very Low
tissue acidosis 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 876 99.88 Very High Very High Very High
Alkalosis 12 90.40 High High
Cv Unclassified Under Development 84 68.16 Quite High
Nociception 12 56.84 Quite High
Acidosis 18 5.00 Very Low Very Low Very Low
Coronary Artery Disease 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Exsanguination 6 5.00 Very Low Very Low Very Low
Overdose 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: The authors recently showed that plasma membrane Ca(2+)-ATPase (PMCA) activity in cerebral synaptic plasma membrane (SPM) is diminished in a dose-related fashion during exposure in vitro to halothane, isoflurane, xenon, and nitrous oxide at clinically relevant partial pressures.
Negative_regulation (diminished) of PMCA in plasma associated with isoflurane and halothane
1) Confidence 0.15 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7832293 Disease Relevance 0 Pain Relevance 0.35
The studies described in this report, in conjunction with previously reported inhibition of PMCA activity in vitro by a wide range of anesthetic agents, indicate a relationship between inhibition of PMCA and action of inhalational anesthetics.


Negative_regulation (inhibition) of PMCA
2) Confidence 0.13 Published 1995 Journal Anesthesiology Section Body Doc Link 7832293 Disease Relevance 0 Pain Relevance 0
The most likely cause of the inhibition of SERCA and PMCA is impaired cellular energy metabolism.
Negative_regulation (inhibition) of PMCA
3) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.33 Pain Relevance 0
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Negative_regulation (inhibition) of PMCA associated with hypoxia
4) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0
We also attempted to assay SERCA-mediated Ca2+ clearance by inhibiting PMCA activity.
Negative_regulation (inhibiting) of PMCA
5) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0
The studies described in this report, in conjunction with previously reported inhibition of PMCA activity in vitro by a wide range of anesthetic agents, indicate a relationship between inhibition of PMCA and action of inhalational anesthetics.


Negative_regulation (inhibition) of PMCA
6) Confidence 0.10 Published 1995 Journal Anesthesiology Section Body Doc Link 7832293 Disease Relevance 0 Pain Relevance 0
We could not therefore block PMCA to directly assess the effects of anoxia on SERCA-mediated cytosolic Ca2+ clearance.


Negative_regulation (block) of PMCA associated with hypoxia
7) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.59 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Negative_regulation (reduced) of PMCA in reticulum associated with hypoxia
8) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.10
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Negative_regulation (reduced) of PMCA associated with hypoxia
9) Confidence 0.04 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0

General Comments

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