INT53285

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 5.43
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c11)
Anatomy Link Frequency
brain 5
1A2 1
Cyp2c11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 97.28 Very High Very High Very High
Inflammatory response 9 96.20 Very High Very High Very High
member 8 1 96.16 Very High Very High Very High
cerebral cortex 8 93.16 High High
Inflammation 24 89.96 High High
opiate 1 89.04 High High
ischemia 80 88.52 High High
algil 4 75.00 Quite High
cytokine 26 67.52 Quite High
Nicotine 2 64.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 63 98.68 Very High Very High Very High
Apoptosis 9 97.98 Very High Very High Very High
Stress 25 97.76 Very High Very High Very High
Appetite Loss 4 97.00 Very High Very High Very High
INFLAMMATION 43 96.20 Very High Very High Very High
Viral Infection 10 96.12 Very High Very High Very High
Lymphatic System Cancer 16 92.92 High High
Leukemia 17 92.56 High High
Middle Cerebral Artery Infarction 112 91.00 High High
Stroke 216 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanism(s) implicated in at least some types of preconditioning include increased Bcl2 and Cyp2C11 expression (Koerner and Alkayed 2007).
Gene_expression (expression) of Cyp2C11
1) Confidence 0.76 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.51 Pain Relevance 0.06
Similarly, up-regulation of Cyp2C11 expression in the brain is unlikely to mediate the neuroprotective effects of developmental A1254 exposure since PCB-related effects on Cyp2C11 expression did not correlate with PCB-related decreases in infarct volume.
Gene_expression (expression) of Cyp2C11 in brain
2) Confidence 0.76 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.30 Pain Relevance 0.03
Similarly, up-regulation of Cyp2C11 expression in the brain is unlikely to mediate the neuroprotective effects of developmental A1254 exposure since PCB-related effects on Cyp2C11 expression did not correlate with PCB-related decreases in infarct volume.
Gene_expression (expression) of Cyp2C11 in brain
3) Confidence 0.76 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.24 Pain Relevance 0.03
Effect of developmental A1254 exposure on Bcl2 and Cyp2C11 expression in the brain.
Gene_expression (expression) of Cyp2C11 in brain
4) Confidence 0.76 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.06 Pain Relevance 0
It is therefore suggested that inhibition or suppression of the expression of CYP2C11 is one of the mechanisms in the toxicity of plant toxins for rats, although it comes from an examination using limited numbers of compounds.
Gene_expression (expression) of CYP2C11 associated with toxicity
5) Confidence 0.73 Published 1998 Journal J Toxicol Sci Section Abstract Doc Link 9922942 Disease Relevance 0.53 Pain Relevance 0.12
Morphine induced a selective down-regulation of hepatic 16 alpha-hydroxylation of androstenedione, which was associated with a reduction in the expression of the 16 alpha-hydroxylation-associated CYP2C11.
Gene_expression (expression) of CYP2C11 associated with morphine
6) Confidence 0.72 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838134 Disease Relevance 0 Pain Relevance 0.47
Developmental PCB exposure modulates systemic (Meerts et al. 2004) and brain (Colciago et al. 2006) levels of estrogen, increases Bcl2 expression in adult testes (Hsu et al. 2007), and increases expression and activity of hepatic Cyp2C11 (Chen et al. 1992; Kramer et al. 1999).
Gene_expression (expression) of Cyp2C11 in brain
7) Confidence 0.66 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 1.05 Pain Relevance 0.16
Primers and probes specific for rat cytochrome P450 2C11 (Cyp2C11, GenBank accession no.
Neg (no) Gene_expression (accession) of Cyp2C11
8) Confidence 0.66 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.19 Pain Relevance 0
In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well.
Gene_expression (decreased) of CYP2C11
9) Confidence 0.61 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.28 Pain Relevance 0
The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis.
Gene_expression (levels) of CYP2C11 in 1A2 associated with appetite loss
10) Confidence 0.61 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.17 Pain Relevance 0
PCB congeners were quantified in brain tissue by gas chromatography with microelectron capture detection, and cortical and striatal expression of Bcl2 and Cyp2C11 were quantified by quantitative reverse transcriptase-polymerase chain reaction.


Gene_expression (expression) of Cyp2C11 in brain
11) Confidence 0.59 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2291013 Disease Relevance 0.68 Pain Relevance 0.09
Effects of developmental A1254 exposure on Bcl2 and Cyp2C11 expression did not correlate with effects on infarct volume.


Gene_expression (expression) of Cyp2C11
12) Confidence 0.59 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2291013 Disease Relevance 0.39 Pain Relevance 0.07
The pregnane × receptor (PXR) is a key regulator of CYP3A transcription and also contributes to CYP2C11 expression patterns [18,19,22].
Gene_expression (expression) of CYP2C11
13) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.17 Pain Relevance 0
Expression profiles for specific examples of genes found in xenobiotic metabolism pathways (Cyp2c11, Cyp2e1, Cyp3a23/3a1, Gstm1, glutathione-s-transferase mu 1; Slc22a8, solute carrier family 22 member 8) and energy metabolism (Phgdh, 3-phosphoglycerate dehydrogenase), which exhibit notable sex and age related differences, are shown in Figure 7.


Gene_expression (Expression) of Cyp2c11 associated with member 8
14) Confidence 0.48 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.30 Pain Relevance 0.10
Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].
Gene_expression (expression) of Cyp2C associated with stress, inflammatory response and apoptosis
15) Confidence 0.46 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.42 Pain Relevance 0.05
CYP2C11 protein expression was significantly suppressed six hours after administration of the WT (37%) and PEGAd (26%) viruses (Figure 4A, p ?
Gene_expression (expression) of CYP2C11 protein
16) Confidence 0.44 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0 Pain Relevance 0
This and data reported previously in which an E1/E3 deleted first generation adenovirus containing some viral gene expression elements but not a transgene cassette and another containing murine erythropoietin [10], further support the hypothesis that changes in the expression and function of CYP2C11 correlates with the immunogenicity of the vector and the trasngene constructs while changes in CYP3A2 may be due to shifts in cellular processes to support transgene production.
Gene_expression (expression) of CYP2C11
17) Confidence 0.44 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.08 Pain Relevance 0
Administration of the helper-dependent and PEGylated viruses did, however, minimize changes in the expression and function of CYP2C11 with expression, activity, with mRNA beginning to recover four days after administration and resolving to baseline by day 14 (Figures 4, 5, 6, p ?
Gene_expression (expression) of CYP2C11
18) Confidence 0.44 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.06 Pain Relevance 0
PPX was produced by CYP2C11 and 3A2, 4'-OH Rop by CYP1A2, and 3'-OH Rop by CYP1A2 and 2D1.
Gene_expression (produced) of CYP2C11
19) Confidence 0.39 Published 1995 Journal Anesthesiology Section Body Doc Link 7832304 Disease Relevance 0 Pain Relevance 0
Effect of a single dose of virus on hepatic CYP2C11 expression and function
Gene_expression (expression) of hepatic CYP2C11
20) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0 Pain Relevance 0

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