INT53287

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (PPP4C) nucleus (PPP4C) cytoplasm (PPP4C)
PPP4C (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 81.36 Quite High
local anesthetic 10 74.28 Quite High
anesthesia 3 73.32 Quite High
epidural 2 72.88 Quite High
analgesia 1 58.28 Quite High
cINOD 1 31.36 Quite Low
Potency 1 26.24 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 3 41.92 Quite Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metabolic activity of ropivacaine was reflected in the production of PPX.
Gene_expression (production) of PPX
1) Confidence 0.63 Published 2006 Journal J Anesth Section Abstract Doc Link 16421682 Disease Relevance 0 Pain Relevance 0.34
The metal-chloroquine (CQ) complexes, Cu(CQ)2Cl (1), Cu(CQ)(PPh3)(NO3) (2), [Cu(OAc)2(CQ)]2 (3) ZnCl2(CQ)(H2O)2 (4), [Zn(OAc)2(CQ)(H2O)]2 (5), were synthesized and characterized by NMR, FAB-mass, elemental analysis, and UV-Vis, EPR and IR spectroscopies.
Gene_expression (synthesized) of PPh3
2) Confidence 0.56 Published 2005 Journal J. Inorg. Biochem. Section Abstract Doc Link 15967505 Disease Relevance 0 Pain Relevance 0
Propofol shows a competitive inhibitory effect on the metabolism of ropivacaine (i.e., PPX production mediated by CYP3A4) in human CYP systems in vitro.
Gene_expression (production) of PPX
3) Confidence 0.49 Published 2006 Journal J Anesth Section Abstract Doc Link 16421682 Disease Relevance 0 Pain Relevance 0.30
The correlation between PPX formation and erythromycin N-demethylase activity showed an R value of 0.99 whereas anti-rabbit CYP3A6 antibody inhibited the degradation of bupivacaine into PPX by 99%.
Gene_expression (formation) of PPX
4) Confidence 0.34 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10725304 Disease Relevance 0 Pain Relevance 0.12
PPX was produced by CYP2C11 and 3A2, 4'-OH Rop by CYP1A2, and 3'-OH Rop by CYP1A2 and 2D1.
Gene_expression (produced) of PPX
5) Confidence 0.08 Published 1995 Journal Anesthesiology Section Body Doc Link 7832304 Disease Relevance 0 Pain Relevance 0
CYP3A4 was involved in producing PPX.
Gene_expression (producing) of PPX
6) Confidence 0.08 Published 1995 Journal Anesthesiology Section Body Doc Link 7832304 Disease Relevance 0 Pain Relevance 0

General Comments

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